Institutional publications

Timing the origin of eukaryotic cellular complexity with ancient duplications

Vosseberg J; van Hooff JJE; Marcet-Houben M; van Vlimmeren A; van Wijk LM; Gabaldón T; Snel B

Nature Ecology & Evolution

(1 )

92 -

100

(2021)

MetaPhOrs 2

Chorostecki U, Molina M, Pryszcz LP, Gabaldón T

Nucleic Acids Research

(W1 )

W553 -

W557

(2021)

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase

Zimmermann F; Serna M; Ezquerra A; Fernandez-Leiro R; Llorca O; Luders J

Science Advances

(51 )

(2020)

Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand

Martínez-Crespo L; Sun-Wang JL; Sierra AF; Aragay G; Errasti-Murugarren E; Bartoccioni P; Palacín M; Ballester P

Chem

(11 )

3054 -

3070

(2020)

The evolution of relapse of adult T cell acute lymphoblastic leukemia

Sentis, Ines; Gonzalez, Santiago; Genesca, Eulalia; Garcia-Hernandez, Violeta; Muinos, Ferran; Gonzalez, Celia; Lopez-Arribillaga, Erika; Gonzalez, Jessica; Fernandez-Ibarrondo, Lierni; Mularoni, Loris; Espinosa, Lluis; Bellosillo, Beatriz; Ribera, Josep-Maria; Bigas, Anna; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria;

Genome Biology

(1 )

284 -

(2020)

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Lynch CJ; Bernad R; Martínez-Val A; Shahbazi MN; Nóbrega-Pereira S; Calvo I; Blanco-Aparicio C; Tarantino C; Garreta E; Richart-Ginés L; Alcazar N; Graña-Castro O; Gómez-Lopez G; Aksoy I; Muñoz-Martín M; Martinez S; Ortega S; Prieto S; Simboeck E; Camasses A; Stephan-Otto Attolini C; Fernandez AF; Sierra MI; Fraga MF; Pastor J; Fisher D; Montserrat N; Savatier P; Muñoz J; Zernicka-Goetz M; Serrano M

Nature Cell Biology

(10 )

1223 -

1238

(2020)

Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

Mateo L; Duran-Frigola M; Gris-Oliver A; Palafox M; Scaltriti M; Razavi P; Chandarlapaty S; Arribas J; Bellet M; Serra V; Aloy P

Genome Medicine

(1 )

78 -

(2020)

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Pittis AA; Goh V; Cebrian-Serrano A; Wettmarshausen J; Perocchi F; Gabaldón T

Nature Communications

(1 )

4031 -

(2020)

A compendium of mutational cancer driver genes

Martínez-Jiménez F; Muiños F; Sentís I; Deu-Pons J; Reyes-Salazar I; Arnedo-Pac C; Mularoni L; Pich O; Bonet J; Kranas H; Gonzalez-Perez A; Lopez-Bigas N

Nature Reviews Cancer

(10 )

555 -

572

(2020)

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Mas-Ponte D; Supek F

Nature Genetics

(9 )

958 -

968

(2020)

Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns

Salvadores, Marina; Fuster-Tormo, Francisco; Supek, Fran

Science Advances

(27 )

(2020)

Selection following gene duplication shapes recent genome evolution in the pea aphid Acyrthosiphon pisum

Fernández R, Marcet-Houben M, Legeai F, Richard G, Robin S, Wucher V, Pegueroles C, Gabaldón T, Tagu D

Molecular Biology And Evolution

(9 )

2601 -

2615

(2020)

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

Ciudad S; Puig E; Botzanowski T; Meigooni M; Arango AS; Do J; Mayzel M; Bayoumi M; Chaignepain S; Maglia G; Cianferani S; Orekhov V; Tajkhorshid E; Bardiaux B; Carulla N

Nature Communications

(1 )

3014 -

(2020)

Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P

Nature Biotechnology

(9 )

1087 -

(2020)

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Morral C; Stanisavljevic J; Hernando-Momblona X; Mereu E; Álvarez-Varela A; Cortina C; Stork D; Slebe F; Turon G; Whissell G; Sevillano M; Merlos-Suárez A; Casanova-Martí À; Moutinho C; Lowe SW; Dow LE; Villanueva A; Sancho E; Heyn H; Batlle E

Cell Stem Cell

(6 )

845 -

861.e12

(2020)

A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress

Viéitez C; Martínez-Cebrián G; Solé C; Böttcher R; Potel CM; Savitski MM; Onnebo S; Fabregat M; Shilatifard A; Posas F; de Nadal E

Nucleic Acids Research

(7 )

3455 -

3475

(2020)

The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer

Pascual, Rosa; Martin, Judit; Salvador, Fernando; Reina, Oscar; Chanes, Veronica; Millanes-Romero, Alba; Suner, Clara; Fernandez-Miranda, Gonzalo; Bartomeu, Anna; Huang, Yi-Shuian; Gomis, Roger R; Mendez, Raul

Science Advances

(20 )

eaax3868 -

(2020)

Hog1 activation delays mitotic exit via phosphorylation of Net1

Tognetti S; Jiménez J; Viganò M; Duch A; Queralt E; de Nadal E; Posas F

Proceedings Of The National Academy Of Sciences Of The United States Of America

117

(16 )

8924 -

8933

(2020)

P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis

Cabré A; Riera A; Verdaguer X

Accounts Of Chemical Research

(3 )

676 -

689

(2020)

Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols

Cabré A; Rafael S; Sciortino G; Ujaque G; Verdaguer X; Lledós A; Riera A

Angewandte Chemie (International Ed. Print)

(19 )

7521 -

7527

(2020)

A multi-modal coarse grained model of DNA flexibility mappable to the atomistic level

Walther J; Dans PD; Balaceanu A; Hospital A; Bayarri G; Orozco M

Nucleic Acids Research

(5 )

e29 -

(2020)

Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers

Barrio L; Milán M

Developmental Cell

(5 )

659 -

672.e3

(2020)

Gene gain and loss across the metazoan tree of life

Fernández R, Gabaldón T

Nature Ecology & Evolution

(4 )

524 -

533

(2020)

The embryonic linker histone dBigH1 alters the functional state of active chromatin

Climent-Cantó P, Carbonell A, Tatarski M, Reina O, Bujosa P, Font-Mateu J, Bernués J, Beato M, Azorín F

Nucleic Acids Research

(8 )

4147 -

4160

(2020)

Requirement for epithelial p38α in KRAS-driven lung tumor progression

Vitos-Faleato J, Real SM, Gutierrez-Prat N, Villanueva A, Llonch E, Drosten M, Barbacid M, Nebreda AR

Proceedings Of The National Academy Of Sciences Of The United States Of America

117

(5 )

2588 -

2596

(2020)

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

Isabel Hernandez-Alvarez, Maria; Sebastian, David; Vives, Sara; Ivanova, Saska; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sonia R.; Hernandez, Vanessa; Vasconcelos, Nuno; Peddinti, Gopal; Adrover, Anna; Jove, Mariona; Pamplona, Reinald; Gordaliza-Alaguero, Isabel; Calvo, Enrique; Cabre, Noemi; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Rodrigues, Cecilia M. P.; Orozco, Modesto; Joven, Jorge; Canto, Carles; Palacin, Manuel; Fernandez-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio;

Cell

177

(4 )

881 -

(2019)

The mutational footprints of cancer therapies

Pich O; Muiños F; Lolkema M; Steeghs N; Gonzalez-Perez A; Lopez-Bigas N

Nature Genetics

(12 )

1732 -

1740

(2019)

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Lindeboom RGH; Vermeulen M; Lehner B; Supek F

Nature Genetics

(11 )

1645 -

1651

(2019)

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

Aragón E; Wang Q; Zou Y; Morgani SM; Ruiz L; Kaczmarska Z; Su J; Torner C; Tian L; Hu J; Shu W; Agrawal S; Gomes T; Márquez JA; Hadjantonakis AK; Macias MJ; Massagué J

Genes & Development

(21-22 )

1506 -

1524

(2019)

Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in drosophila

Sanchez J; Mesquita D; Ingaramo M; Ariel F; Milan M; Dekanty A

Plos Genetics

(8 )

e1008133 -

(2019)

Atomic structure of the Epstein-Barr virus portal

Machón C; Fàbrega-Ferrer M; Zhou D; Cuervo A; Carrascosa J; Stuart D; Coll M

Nature Communications

(1 )

3891 -

(2019)

Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism

Cuervo A; Fàbrega-Ferrer M; Machón C; Conesa J; Fernández F; Pérez-Luque R; Pérez-Ruiz M; Pous J; Vega M; Carrascosa J; Coll M

Nature Communications

(1 )

3746 -

(2019)

Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage

Murcia L; Clemente-Ruiz M; Pierre-Elies P; Royou A; Milán M

Cell Reports

(1 )

119 -

131.e4

(2019)

Defining the Independence of the Liver Circadian Clock

Koronowski KB; Kinouchi K; Welz PS; Smith JG; Zinna VM; Shi J; Samad M; Chen S; Magnan CN; Kinchen JM; Li W; Baldi P; Benitah SA; Sassone-Corsi P

Cell

177

(6 )

1448 -

1462.e14

(2019)

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

Welz PS; Zinna VM; Symeonidi A; Koronowski KB; Kinouchi K; Smith JG; Guillén IM; Castellanos A; Crainiciuc G; Prats N; Caballero JM; Hidalgo A; Sassone-Corsi P; Benitah SA

Cell

177

(6 )

1436 -

1447.e12

(2019)

Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments

Torres AG; Reina O; Attolini CSO; De Pouplana LR

Proceedings Of The National Academy Of Sciences Of The United States Of America

116

(17 )

8451 -

8456

(2019)

Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope

Orellana L; Thorne AH; Lema R; Gustavsson J; Parisian AD; Hospital A; Cordeiro TN; Bernadó P; Scott AM; Brun-Heath I; Lindahl E; Cavenee WK; Furnari FB; Orozco M

Proceedings Of The National Academy Of Sciences Of The United States Of America

116

(20 )

10009 -

10018

(2019)

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Escobedo A; Topal B; Kunze M; Aranda J; Chiesa G; Mungianu D; Bernardo-Seisdedos G; Eftekharzadeh B; Gairí M; Pierattelli R; Felli I; Diercks T; Millet O; García J; Orozco M; Crehuet R; Lindorff-Larsen K; Salvatella X

Nature Communications

(1 )

2034 -

(2019)

Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit

Picchioni D; Antolin-Fontes A; Camacho N; Schmitz C; Pons-Pons A; Rodríguez-Escribà M; Machallekidou A; Güler MN; Siatra P; Carretero-Junquera M; Serrano A; Hovde SL; Knobel PA; Novoa EM; Solà-Vilarrubias M; Kaguni LS; Stracker TH; Ribas de Pouplana L

Cell Reports

(1 )

40 -

47.e5

(2019)

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

Benhra N; Barrio L; Muzzopappa M; Milán M

Developmental Cell

(2 )

161 -

174.e4

(2018)

Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes

Pich O; Muiños F; Sabarinathan R; Reyes-Salazar I; Gonzalez-Perez A; Lopez-Bigas N

Cell

175

(4 )

1074 -

1087.e18

(2018)

A versatile drug delivery system targeting senescent cells

Muñoz-Espín D; Rovira M; Galiana I; Giménez C; Lozano-Torres B; Paez-Ribes M; Llanos S; Chaib S; Muñoz-Martín M; Ucero AC; Garaulet G; Mulero F; Dann SG; VanArsdale T; Shields DJ; Bernardos A; Murguía JR; Martínez-Máñez R; Serrano M

Embo Molecular Medicine

(9 )

(2018)

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

Parras A; Anta H; Santos-Galindo M; Swarup V; Elorza A; Nieto-González J; Picó S; Hernández I; Díaz-Hernández J; Belloc E; Rodolosse A; Parikshak N; Peñagarikano O; Fernández-Chacón R; Irimia M; Navarro P; Geschwind D; Méndez R; Lucas J

Nature

560

(7719 )

441 -

446

(2018)

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.

Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS, Batlle E

Nature

554

(7693 )

538 -

543

(2018)

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

Cánovas B; Igea A; Sartori A; Gomis R; Paull T; Isoda M; Pérez-Montoyo H; Serra V; González-Suárez E; Stracker T; Nebreda A

Cancer Cell

(6 )

1094 -

1110.e8

(2018)

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