Llorenc Escanellas

Unit:

Mechanisms of Disease

Position:

Former - Visiting Student

Office:

EM01B41-42

Telephone:

+34 93 40 37188

Email:

llorenc.escanellas@irbbarcelona.org

Left IRB Barcelona in July 2020

Research Group

Structural Characterization of Macromolecular Assemblies

Mecanismes de Malaltia

Selected group publications

TGF-β and RAS jointly unmask primed enhancers to drive metastasis

Lee, Jun Ho; Sánchez-Rivera, Francisco J.; He, Lan; Basnet, Harihar; Chen, Fei Xavier; Spina, Elena; Li, Liangji; Torner, Carles; Chan, Jason E.; Yarlagadda, Dig Vijay Kumar; Park, Jin Suk; Sussman, Carleigh; Rudin, Charles M.; Lowe, Scott W.; Tammela, Tuomas; Macias, Maria J.; Koche, Richard P.; Massagué, Joan

Cell,

187

(22 )

6182

- 6199.e29

(2024-09-06)

AI is a viable alternative to high throughput screening: a 318-target study

Wallach, I; Bernard, D; Nguyen, K; Ho, G; Morrison, A; Stecula, A; Rosnik, A; O'Sullivan, AM; Davtyan, A; Samudio, B; Thomas, B; Worley, B; Butler, B; Laggner, C; Thayer, D; Moharreri, E; Friedland, G; Truong, H; van den Bedem, H; Ng, HL; Stafford, K; Sarangapani, K; Giesler, K; Ngo, L; Mysinger, M; Ahmed, M; Anthis, NJ; Henriksen, N; Gniewek, P;...

Scientific Reports,

(1 )

7526

(2024-04-02)

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

Pous, J; Baginski, B; Martin-Malpartida, P; González, L; Scarpa, M; Aragon, E; Ruiz, L; Mees, RA; Iglesias-Fernández, J; Orozco, M; Nebreda, AR; Macias, MJ

Nature Communications,

(1 )

7920

(2023-12-01)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR

Nature Communications,

(1 )

3318

(2023-06-12)

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1

Pluta, R; Aragon, E; Prescott, NA; Ruiz, L; Mees, RA; Baginski, B; Flood, JR; Martin-Malpartida, P; Massague, J; David, Y; Macias, MJ

Nature Communications,

(1 )

7279

(2022-11-26)

HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings: HTSDSF Explorer, a tool for DSF screenings

Martin-Malpartida, P; Hausvik, E; Underhaug, J; Torner, C; Martinez, A; Macias, MJ

Journal Of Molecular Biology,

434

(11 )

167372

(2022-06-15)

Conformational ensemble of the TNF-derived peptide solnatide in solution

Martin-Malpartida, P; Arrastia-Casado, S; Farrera-Sinfreu, J; Lucas, R; Fischer, H; Fischer, B; Eaton, DC; Tzotzos, S; Macias, MJ

Computational And Structural Biotechnology Journal,

2082

- 2090

(2022-01-01)

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Rol, A; Todorovski, T; Martin-Malpartida, P; Escolà, A; Gonzalez-Rey, E; Aragón, E; Verdaguer, X; Vallès-Miret, M; Farrera-Sinfreu, J; Puig, E; Fernández-Carneado, J; Ponsati, B; Delgado, M; Riera, A; Macias, MJ

Nature Communications,

(1 )

1869

(2021-03-25)

Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins

Freier, R; Aragon, E; Pluta, R; Martin-Malpartida, P; Ruiz, L; Condeminas, M; Gonzalez, C; Macias, MJ

Iucrj,

(Pt 2 )

281

- 294

(2021-03-01)