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Recerca

A l'avantguarda de la biomedicina

Publicacions de recerca

Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response
Ricolo, D; Casanova, J; Giannios, P
Science Advances
11
13
eads2086 -
-
2025
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse
Heras-Murillo, Ignacio; Mañanes, Diego; Munné, Pablo; Núñez, Vanessa; Herrera, Jessica; Catalá-Montoro, Mauro; Alvarez, Maite; del Pozo, Miguel A.; Melero, Ignacio; Wculek, Stefanie K #; Sancho, David #
# Corresponding author
Nature Communications
16
1
3369 -
-
2025
Transcriptional heterogeneity shapes stress-adaptive responses in yeast
Nadal-Ribelles, Mariona; Lieb, Guillaume; Solé, Carme; Matas, Yaima; Szachnowski, Ugo; Andjus, Sara; Quintana, Maria; Romo, Mònica; Herrero, Aitor Gonzalez; Morillon, Antonin; Pelet, Serge; de Nadal, Eulàlia; Posas, Francesc
Nature Communications
16
1
2631 -
-
2025
Autocrine Wingless constricts the Drosophila embryonic gut by Ca+2-mediated repolarisation of mesoderm cells
Ricolo, D; Tamba, F; Casanova, J
Embo Reports
-
-
- -
-
2025
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations
Nadal-Ribelles, Mariona; Solé, Carme; Díez-Villanueva, Anna; Stephan-Otto Attolini, Camille; Matas, Yaima; Steinmetz, Lars; de Nadal, Eulàlia; Posas, Francesc
Nature Communications
16
1
2645 -
-
2025
Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations
Singh, Indranil; Fernandez-Perez, Daniel; Sanchez, Pedro Sanchez; Rodriguez-Fraticelli, Alejo E.
Cell Stem Cell
-
-
- -
-
2025
Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing
Perucca, Alice; Llonin, Andrea Gomez; Benach, Oriol Mane; Hallopeau, Clement; Rivas, Elisa I; Linares, Jenniffer; Garrido, Marta; Sallent-Aragay, Anna; Golde, Tom; Colombelli, Julien; Dalaka, Eleni; Linacero, Judith; Cazorla, Marina; Galan, Teresa; Pastor Viel, Jordi; Badenas, Xavier; Recort-Bascuas, Alba; Comerma, Laura; Fernandez-Nogueira,...
Nature Communications
16
1
1279 -
-
2025
Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis
Giroud-Gerbetant, Judith; Sotillo, Fernando; Hernández, Gonzalo; Ruano, Irene; Sebastián, David; Fort, Joana; Sánchez, Mayka; Weiss, Günter; Prats, Neus; Zorzano, Antonio; Palacín, Manuel; Bodoy, Susanna
Molecular Medicine
31
1
29 -
-
2025
Redox proteomics reveal a role for peroxiredoxinylation in stress protection
Seisenbacher, Gerhard; Nakic, Zrinka Raguz; Borràs, Eva; Sabidó, Eduard; Sauer, Uwe; de Nadal, Eulalia; Posas, Francesc
Cell Reports
44
2
115224 -
-
2025
The conserved lysine residue in transmembrane helix 5 is key for the cytoplasmic gating of the L-amino acid transporters
Fort, Joana; Nicolàs-Aragó, Adrià; Maggi, Luca; Martinez Molledo, Maria; Kapiki, Despoina; Gonzalez-Novoa, Paula; Gómez-Gejo, Patricia; Zijlstra, Niels; Bodoy, Susanna; Pardon, Els; Steyaert, Jan; Llorca, Oscar; Orozco, Modesto; Cordes, Thorben; Palacín, Manuel
Pnas Nexus
4
1
pgae584 -
-
2025
Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD
Garcia-Cabau C; Bartomeu A; Tesei G; Cheung KC; Pose-Utrilla J; Picó S; Balaceanu A; Duran-Arqué B; Fernández-Alfara M; Martín J; De Pace C; Ruiz-Pérez L; García J; Battaglia G; Lucas JJ; Hervás R; Lindorff-Larsen K; Méndez R; Salvatella X
Nature
637
8045
496 -
503
2025
TGF-β and RAS jointly unmask primed enhancers to drive metastasis
Lee, Jun Ho; Sánchez-Rivera, Francisco J.; He, Lan; Basnet, Harihar; Chen, Fei Xavier; Spina, Elena; Li, Liangji; Torner, Carles; Chan, Jason E.; Yarlagadda, Dig Vijay Kumar; Park, Jin Suk; Sussman, Carleigh; Rudin, Charles M.; Lowe, Scott W.; Tammela, Tuomas; Macias, Maria J.; Koche, Richard P.; Massagué, Joan
Cell
187
22
6182 -
6199.e29
2024
CDK5RAP2 activates microtubule nucleator γTuRC by facilitating template formation and actin release
Serna, M; Zimmermann, F; Vineethakumari, C; Gonzalez-Rodriguez, N; Llorca, O; Lüders, J
Developmental Cell
59
23
3175 -
3188
2024
Five latent factors underlie response to immunotherapy
Usset, Joseph; Rosendahl Huber, Axel; Andrianova, Maria A.; Batlle, Eduard; Carles, Joan; Cuppen, Edwin; Elez, Elena; Felip, Enriqueta; Gómez-Rey, Marina; Lo Giacco, Deborah; Martinez-Jimenez, Francisco; Muñoz-Couselo, Eva; Siu, Lillian L.; Tabernero, Josep; Vivancos, Ana; Muiños, Ferran; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria
Nature Genetics
56:
-
2112 -
2120
2024
Comprehensive detection and characterization of human druggable pockets through binding site descriptors
Comajuncosa-Creus, Arnau; Jorba, Guillem; Barril, Xavier; Aloy, Patrick
Nature Communications
15
1
7917 -
-
2024
Metabolic homeostasis of tissue macrophages across the lifespan
Wculek, Stefanie K. (#); Forisch, Stephan; Miguel, Verónica; Sancho, David (#)
(#) Corresponding author
Trends In Endocrinology And Metabolism
-
-
- -
-
2024
Harnessing dendritic cell metabolism for healthy ageing: reducing the risk of cardiovascular disease?
Wculek, SK
European Heart Journal
45
27
2355 -
2357
2024
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, I; Bernard, D; Nguyen, K; Ho, G; Morrison, A; Stecula, A; Rosnik, A; O'Sullivan, AM; Davtyan, A; Samudio, B; Thomas, B; Worley, B; Butler, B; Laggner, C; Thayer, D; Moharreri, E; Friedland, G; Truong, H; van den Bedem, H; Ng, HL; Stafford, K; Sarangapani, K; Giesler, K; Ngo, L; Mysinger, M; Ahmed, M; Anthis, NJ; Henriksen, N; Gniewek, P;...
Scientific Reports
14
1
7526 -
-
2024
Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues
Sánchez-Guixé, Mònica; Muiños, Ferran; Pinheiro-Santin, Morena; González-Huici, Víctor; Rodriguez-Hernandez, Carlos J.; Avgustinova, Alexandra; Lavarino, Cinzia; González-Pérez, Abel; Mora, Jaume; López-Bigas, Núria
Cancer Discovery
-
-
OF1 -
OF12
2024
Mechanisms of metastatic colorectal cancer
Cañellas-Socias, Adrià; Sancho, Elena; Batlle, Eduard
Nature Reviews Gastroenterology & Hepatology
21
9
609 -
625
2024
Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Demajo, Santiago; Ramis-Zaldivar; Joan Enric, Muiños, Ferran; Grau, Miquel L; Andrianova, Maria; López-Bigas, Núria; González-Pérez, Abel.
Cancer Discovery
14
9
1717 -
1731
2024
Innovating in a bioimaging core through instrument development
Munck, S; De Bo, C; Cawthorne, C; Colombelli, J
Journal Of Microscopy
294
3
319 -
337
2024
Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells
Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C
Nucleic Acids Research
52
6
3375 -
3389
2024
Dendritic cells as orchestrators of anticancer immunity and immunotherapy
Heras-Murillo, I; Adán-Barrientos, I; Galán, M; Wculek, SK (#) ; Sancho, D (#)
(#) Corresponding author
Nature Reviews Clinical Oncology
21
4
257 -
277
2024
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chaib S; López-Domínguez JA; Lalinde-Gutiérrez M; Prats N; Marin I; Boix O; García-Garijo A; Meyer K; Muñoz MI; Aguilera M; Mateo L; Stephan-Otto Attolini C; Llanos S; Pérez-Ramos S; Escorihuela M; Al-Shahrour F; Cash TP; Tchkonia T; Kirkland JL; Abad M; Gros A; Arribas J; Serrano M
Nature Cancer
5
3
448 -
462
2024
Urease-powered nanobots for radionuclide bladder cancer therapy
Simo, C; Serra-Casablancas, M; Hortelao, AC; Di Carlo, V; Guallar-Garrido, S; Plaza-Garcia, S; Rabanal, RM; Ramos-Cabrer, P; Yaguee, B; Aguado, L; Bardia, L; Tosi, S; Gomez-Vallejo, V; Martin, A; Patino, T; Julian, E; Colombelli, J; Llop, J; Sanchez, S
Nature Nanotechnology
19
-
554 -
564
2024
Hotspot propensity across mutational processes
Arnedo-Pac C, Muiños F, Gonzalez-Perez A, Lopez-Bigas N
Molecular Systems Biology
20
1
6 -
27
2024
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, MA; Gabaldón, T
Nature Microbiology
9
1
284 -
307
2024
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C
Angewandte Chemie (International Ed. Print)
63
12
e202316730 -
e202316730
2024
MAF amplification licenses ERa through epigenetic remodelling to drive breast cancer metastasis
Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballè, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR
Nature Cell Biology
25
12
1833 -
1847
2023
Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity
Marin, I; Boix, O; Garcia-Garijo, A; Sirois, I; Caballe, A; Zarzuela, E; Ruano, I; Attolini, CSO; Prats, N; López-Domínguez, JA; Kovatcheva, M; Garralda, E; Muñoz, J; Caron, E; Abad, M; Gros, A; Pietrocola, F; Serrano, M
Cancer Discovery
13
2
410 -
431
2023
Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
Pous, J; Baginski, B; Martin-Malpartida, P; González, L; Scarpa, M; Aragon, E; Ruiz, L; Mees, RA; Iglesias-Fernández, J; Orozco, M; Nebreda, AR; Macias, MJ
Nature Communications
14
1
7920 -
-
2023
Origin of fungal hybrids with pathogenic potential from warm seawater environments
del Olmo, V; Mixao, V; Fotedar, R; Saus, E; Al Malki, A; Ksiezopolska, E; Nunez-Rodriguez, JC; Boekhout, T; Gabaldón, T
Nature Communications
14
1
6919 -
-
2023
Rational optimization of a transcription factor activation domain inhibitor
Basu, S; Martínez-Cristóbal, P; Frigolé-Vivas, M; Pesarrodona, M; Lewis, M; Szulc, E; Bañuelos, CA; Sánchez-Zarzalejo, C; Bielskute, S; Zhu, JQ; Pombo-García, K; Garcia-Cabau, C; Zodi, L; Dockx, H; Smak, J; Kaur, H; Batlle, C; Mateos, B; Biesaga, M; Escobedo, A; Bardia, L; Verdaguer, X; Ruffoni, A; Mawji, NR; Wang, J; Obst, JK; Tam, T;...
Nature Structural & Molecular Biology
30
-
1958 -
1969
2023
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M
Nature Metabolism
5
11
1911 -
1930
2023
Roastgsa: a comparison of rotation-based scores for gene set enrichment analysis
Caballé-Mestres, A; Berenguer-Llergo, A; Attolini, CSO
Bmc Bioinformatics
24
1
408 -
-
2023
A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing
Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M
Nature Cell Biology
25
11
1590 -
1599
2023
Chromosomal instability-induced cell invasion through caspase-driven DNA damage
Barrio, L; Gaspar, AE; Muzzopappa, M; Ghosh, K; Romao, D; Clemente-Ruiz, M; Milan, M
Current Biology
33
20
S0960 -
4
2023
Expansion microscopy of the chick embryo neural tube to overcome molecular crowding at the centrosomes-cilia
Wilmerding, A; Espana-Bonilla, P; Giakoumakis, NN; Saade, M
Star Protocols
4
1
101997 -
-
2023
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy
Redondo-Munoz, M; Rodriguez-Baena, FJ; Aldaz, P; Caballe-Mestres, A; Moncho-Amor, V; Otaegi-Ugartemendia, M; Carrasco-Garcia, E; Olias-Arjona, A; Lasheras-Otero, I; Santamaria, E; Bocanegra, A; Chocarro, L; Grier, A; Dzieciatkowska, MM; Bigas, C; Martin, J; Urdiroz-Urricelqui, U; Marzo, F; Santamaria, E; Kochan, G; Escors, D; Larrayoz, IM; Heyn,...
Nature Metabolism
5
9
1544 -
+
2023
scKINETICS: inference of regulatory velocity with single-cell transcriptomics data
Burdziak, C; Zhao, CJ; Haviv, D; Alonso-Curbelo, D; Lowe, SW; Pe'er, D
Bioinformatics
39
39 Suppl 1
i394 -
i403
2023
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L
Science
380
6651
eadh9351 -
eadh9351
2023
Targeting lymphoid-derived IL-17 signaling to delay skin aging
Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA
Nature Aging
3
6
688 -
+
2023
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR
Nature Communications
14
1
3318 -
-
2023
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M
Nucleic Acids Research
51
10
4713 -
4725
2023
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D
Science
380
6645
597 -
+
2023
Biophysical and computational approaches to study ternary complexes: A 'cooperative relationship' to rationalize targeted protein degradation
Ward JA, Perez-Lopez C, Mayor-Ruiz C
Chembiochem
24
10
e202300163 -
e202300163
2023
Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation
Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C
Chembiochem
24
10
- -
-
2023