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Recerca

A l'avantguarda de la biomedicina

Publicacions de recerca

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR
Nature Communications
14
1
3318 -
-
2023
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M
Nucleic Acids Research
51
10
4713 -
4725
2023
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D
Science
380
6645
597 -
+
2023
Biophysical and computational approaches to study ternary complexes: A 'cooperative relationship' to rationalize targeted protein degradation
Ward JA, Perez-Lopez C, Mayor-Ruiz C
Chembiochem
24
10
e202300163 -
e202300163
2023
Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation
Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C
Chembiochem
24
10
- -
-
2023
Correlated motions in DNA: beyond base-pair step models of DNA flexibility
López-Güell, K; Battistini, F; Orozco, M
Nucleic Acids Research
51
6
2633 -
2640
2023
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress
Fernández-Alfara, M; Sibilio, A; Martin, J; Uxó, ET; Malumbres, M; Alcalde, V; Chanes, V; Cañellas-Socias, A; Palomo-Ponce, S; Batlle, E; Méndez, R
Embo Journal
42
9
e111494 -
-
2023
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
Maus, M; López-Polo, V; Mateo, L; Lafarga, M; Aguilera, M; De Lama, E; Meyer, K; Sola, A; Lopez-Martinez, C; López-Alonso, I; Guasch-Piqueras, M; Hernandez-Gonzalez, F; Chaib, S; Rovira, M; Sanchez, M; Faner, R; Agusti, A; Diéguez-Hurtado, R; Ortega, S; Manonelles, A; Engelhardt, S; Monteiro, F; Attolini, CSO; Prats, N; Albaiceta, G; Cruzado,...
Nature Metabolism
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5
2111 -
2130
2023
Characterization of p38α signaling networks in cancer cells using quantitative proteomics and phosphoproteomics
Dan, YZ; Radic, N; Gay, M; Fernández-Torras, A; Arauz, G; Vilaseca, M; Aloy, P; Canos, B; Nebreda, AR
Molecular & Cellular Proteomics
22
4
100527 -
-
2023
Transient and DNA-free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis
Navaridas, R; Vidal-Sabanés, M; Ruiz-Mitjana, A; Perramon-Güell, A; Megino-Luque, C; Llobet-Navas, D; Matias-Guiu, X; Egea, J; Encinas, M; Bardia, L; Colombelli, J; Dolcet, X
Cancer Communications
43
5
620 -
624
2023
Copy number footprints of platinum-based anticancer therapies
Gonzalez, S; Lopez-Bigas, N; Gonzalez-Perez, A
Plos Genetics
19
2
e1010634 -
-
2023
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
Mensah, MA; Niskanen, H; Magalhaes, AP; Basu, S; Kircher, M; Sczakiel, HL; Reiter, AMV; Elsner, J; Meinecke, P; Biskup, S; Chung, BHY; Dombrowsky, G; Eckmann-Scholz, C; Hitz, MP; Hoischen, A; Holterhus, PM; Hülsemann, W; Kahrizi, K; Kalscheuer, VM; Kan, A; Krumbiegel, M; Kurth, I; Leubner, J; Longardt, AC; Moritz, JD; Najmabadi, H; Skipalova, K;...
Nature
614
7948
564 -
+
2023
pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs
Serrano-Chacon, I; Mir, B; Cupellini, L; Colizzi, F; Orozco, M; Escaja, N; Gonzalez, C
Journal Of The American Chemical Society
145
6
3696 -
3705
2023
Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG
Ali, A; Vineethakumari, C; Lacasa, C; Lüders, J
Nature Communications
14
1
289 -
-
2023
Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein
Machón, C; Ruiz-Masó, JA; Amodio, J; Boer, DR; Bordanaba-Ruiseco, L; Bury, K; Konieczny, I; del Solar, G; Coll, M
Nucleic Acids Research
51
3
1458 -
1472
2023
Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
Irazoki, A; Gordaliza-Alaguero, I; Frank, E; Giakoumakis, NN; Seco, J; Palacín, M; Guma, A; Sylow, L; Sebastián, D; Zorzano, A
Nature Communications
14
1
108 -
-
2023
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Wculek SK#, Heras-Murillo I, Mastrangelo A, Mañanes D, Galán M, Miguel V, Curtabbi A, Barbas, C, Chandel NS, Enríquez JA, Lamas S, Sancho D#
(#) Corresponding author
Immunity
(56:1-15)
2023
Local IL-17 orchestrates skin aging
Solá, Paloma; Mereu, Elisabetta; Bonjoch, Júlia; Casado, Marta; Reina, Oscar; Blanco, Enrique; Esteller, Manel; DiCroce, Luciano; Heyn, Holger; Solanas, Guiomar; Benitah, Salvador Aznar
Biorxiv : The Preprint Server For Biology
-
-
- -
-
2022
Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans.
Carreté L; Ksiezopolska E; Pegueroles C; Gómez-Molero E; Saus E; Iraola-Guzmán S; Loska D; Bader O; Fairhead C; Gabaldón T
Current Biology
32
14
3219 -
3219
2022
Molecular glue degraders: From serendipity to hunting and design
Nieto-Barrado L; Domostegui A; Mayor-Ruiz C
In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.
-
-
177 -
204
2022
Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
Aranda, J; Wieczor, M; Terrazas, M; Brun-Heath, I; Orozco, M
Chem Catalysis
2
5
1084 -
1099
2022
Implementing re-configurable biological computation with distributed multicellular consortia
Canadell, D; Ortiz-Vaquerizas, N; Mogas-Diez, S; de Nadal, E; Macia, J; Posas, F
Nucleic Acids Research
50
21
12578 -
12595
2022
Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1
Pluta, R; Aragon, E; Prescott, NA; Ruiz, L; Mees, RA; Baginski, B; Flood, JR; Martin-Malpartida, P; Massague, J; David, Y; Macias, MJ
Nature Communications
13
1
7279 -
-
2022
A glutamine-based single α-helix scaffold to target globular proteins
Escobedo, A; Piccirillo, J; Aranda, J; Diercks, T; Mateos, B; Garcia-Cabau, C; Sánchez-Navarro, M; Topal, B; Biesaga, M; Staby, L; Kragelund, BB; García, J; Millet, O; Orozco, M; Coles, M; Crehuet, R; Salvatella, X
Nature Communications
13
1
7073 -
-
2022
Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis
Molnar, C; Reina, J; Herrero, A; Heinen, JP; Méndiz, V; Bonnal, S; Irimia, M; Sánchez-Jiménez, M; Sánchez-Molina, S; Mora, J; Gonzalez, C
Pnas Nexus
1
4
pgac222 -
-
2022
Illuminati: a form of gene expression plasticity in Drosophila neural stem cells
Goupil, A; Heinen, JP; Salame, R; Rossi, F; Reina, J; Pennetier, C; Simon, A; Skorski, P; Louzao, A; Bardin, AJ; Basto, R; Gonzalez, C
Development
149
22
200808 -
-
2022
Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X;...
Nature
611
7936
603 -
613
2022
Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states
Zhu, JQ; Salvatella, X; Robustelli, P
Nature Communications
13
1
6390 -
-
2022
Deciphering the roadmap of in vivo reprogramming toward pluripotency
Chondronasiou, D; de Villarreal, JM; Melendez, E; Lynch, CJ; del Pozo, N; Kovatcheva, M; Aguilera, M; Prats, N; Real, FX; Serrano, M
Stem Cell Reports
17
11
2501 -
2517
2022
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation
Gonzalez-Arzola, K; Diaz-Quintana, A; Bernardo-Garcia, N; Martinez-Fabregas, J; Rivero-Rodriguez, F; Casado-Combreras, MA; Elena-Real, CA; Velazquez-Cruz, A; Gil-Caballero, S; Velazquez-Campoy, A; Szulc, E; Gavilan, MP; Ayala, I; Arranz, R; Rios, RM; Salvatella, X; Valpuesta, JM; Hermoso, JA; De la Rosa, MA; Diaz-Moreno, I
Nature Structural & Molecular Biology
29
10
1024 -
+
2022
The role of lipids in cancer progression and metastasis
Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah SA
Cell Metabolism
34
11
1675 -
1699
2022
The role of lipids in cancer progression and metastasis
Martin-Perez, M; Urdiroz-Urricelqui, U; Bigas, C; Benitah, SA
Cell Metabolism
34
11
1675 -
1699
2022
Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
Ulsamer, A; Martínez-Limón, A; Bader, S; Rodríguez-Acebes, S; Freire, R; Méndez, J; de Nadal, E; Posas, F
Cell Reports
40
12
111375 -
-
2022
Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque
Fernández-Torras, A; Duran-Frigola, M; Bertoni, M; Locatelli, M; Aloy, P
Nature Communications
13
1
5304 -
-
2022
Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation
Duran-Arqué, B; Cañete, M; Castellazzi, CL; Bartomeu, A; Ferrer-Caelles, A; Reina, O; Caballé, A; Gay, M; Arauz-Garofalo, G; Belloc, E; Mendez, R
Genome Biology
23
1
192 -
-
2022
Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors
Rivas, EI; Linares, J; Zwick, M; Gómez-Llonin, A; Guiu, M; Labernadie, A; Badia-Ramentol, J; Lladó, A; Bardia, L; Pérez-Núñez, I; Martínez-Ciarpaglini, C; Tarazona, N; Sallent-Aragay, A; Garrido, M; Celià-Terrassa, T; Burgués, O; Gomis, RR; Albanell, J; Calon, A
Nature Communications
13
1
5310 -
-
2022
The lysosomal proteome of senescent cells contributes to the senescence secretome
Rovira, M; Sereda, R; Pladevall-Morera, D; Ramponi, V; Marin, I; Maus, M; Madrigal-Matute, J; Díaz, A; García, F; Muñoz, J; Cuervo, AM; Serrano, M
Aging Cell
21
10
e13707 -
-
2022
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
Bernués, J; Izquierdo-Boulstridge, A; Reina, O; Castejón, L; Fernández-Castañer, E; Leal, N; Guerrero-Pepinosa, N; Bonet-Costa, C; Vujatovic, O; Climent-Cantó, P; Azorín, F
Nucleic Acids Research
50
16
9212 -
9225
2022
Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure
Riera-Escamilla, A; Vockel, M; Nagirnaja, L; Xavier, MJ; Carbonell, A; Moreno-Mendoza, D; Pybus, M; Farnetani, G; Rosta, V; Cioppi, F; Friedrich, C; Oud, MS; van der Heijden, GW; Soave, A; Diemer, T; Ars, E; Sánchez-Curbelo, J; Kliesch, S; O'Bryan, MK; Ruiz-Castañe, E; Azorín, F; Veltman, JA; Aston, KI; Conrad, DF; Tüttelmann, F; Krausz, C
American Journal Of Human Genetics
109
8
1458 -
1471
2022
DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
Barissi, S; Sala, A; Wieczór, M; Battistini, F; Orozco, M
Nucleic Acids Research
50
16
9105 -
9114
2022
Discovering the drivers of clonal hematopoiesis
Pich, O; Reyes-Salazar, I; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Communications
13
1
4267 -
-
2022
A single WNT enhancer drives specification and regeneration of the Drosophila wing
Gracia-Latorre, E; Pérez, L; Muzzopappa, M; Milán, M
Nature Communications
13
1
4794 -
-
2022
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
Alvarez, MM; Biayna, J; Supek, F
Nature Communications
13
1
4520 -
-
2022
PerSVade: personalized structural variant detection in any species of interest
Schikora-Tamarit, MA; Gabaldón, T
Genome Biology
23
1
175 -
-
2022
The impact of rare germline variants on human somatic mutation processes
Vali-Pour, M; Lehner, B; Supek, F
Nature Communications
13
1
3724 -
-
2022
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Delaunay, S; Pascual, G; Feng, BH; Klann, K; Behm, M; Hotz-Wagenblatt, A; Richter, K; Zaoui, K; Herpel, E; Munch, C; Dietmann, S; Hess, J; Benitah, SA; Frye, M
Nature
607
7919
593 -
+
2022
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Delaunay, S; Pascual, G; Feng, BH; Klann, K; Behm, M; Hotz-Wagenblatt, A; Richter, K; Zaoui, K; Herpel, E; Munch, C; Dietmann, S; Hess, J; Benitah, SA; Frye, M
Nature
607
7919
593 -
+
2022
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
Alvarez-Varela, A; Novellasdemunt, L; Barriga, FM; Hernando-Momblona, X; Canellas-Socias, A; Cano-Crespo, S; Sevillano, M; Cortina, C; Stork, D; Morral, C; Turon, G; Slebe, F; Jimenez-Gracia, L; Caratu, G; Jung, P; Stassi, G; Heyn, H; Tauriello, DVF; Mateo, L; Tejpar, S; Sancho, E; Attolini, CSO; Batlle, E
Nature Cancer
3
9
1052 -
+
2022
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