IRB Barcelona logo

Recerca

A l'avantguarda de la biomedicina

Publicacions de recerca

Dendritic cells in cancer immunology and immunotherapy
Wculek SK*, Cueto FJ*, Mujal AM, Melero I, Krummel MF, Sancho D#
(#) Corresponding author; (*) these authors contributed equally
Nature Reviews Immunology
20(1):7-24
2020
Early neutrophil responses to chemical carcinogenesis shape long-term lung cancer susceptibility
Wculek SK*, Bridgeman VL*, Peakman F, Malanchi I#
(#) Corresponding author; (*) these authors contributed equally
iScience
23(7):101277
2020
Senolytic CAR T cells reverse senescence-associated pathologies
Amor C*, Feucht J*, Leibold J*, Ho Y-J, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, et al, Sadelain M, Lowe SW.
(*) these authors contributed equally
Nature
2020
An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants
Paz Zafra M, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Calvo Fernandez MT, Wilkinson JE, Piskounova E and Dow LE.
Cancer Discovery
2020
Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E
Nat Chem Bio
2020
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Alejo E Rodriguez-Fraticelli, Caleb S Weinreb, Shou Wen Wang, Rosa P Migueles, Maja Jankovic, Marc Usart, Allon M Klein, Sally Lowell, Fernando D Camargo
Nature
2020
Lineage tracing on transcriptional landscapes links state to fate during differentiation
Caleb S Weinreb(#), Alejo E Rodriguez-Fraticelli(#), Fernando D Camargo, Allon M Klein (# Equal contribution)
Science
2020
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Hernández-Alvarez, MI; Sebastián, D; Vives, S; Ivanova, S; Bartoccioni, P; Kakimoto, P; Plana, N; Veiga, SR; Hernández, V; Vasconcelos, N; Peddinti, G; Adrover, A; Jové, M; Pamplona, R; Gordaliza-Alaguero, I; Calvo, E; Cabré, N; Castro, R; Kuzmanic, A; Boutant, M; Sala, D; Hyotylainen, T; Oresic, M; Fort, J; Errasti-Murugarren, E;...
Cell
177
4
881 -
+
2019
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh, B; Banduseela, VC; Chiesa, G; Martínez-Cristóbal, P; Rauch, JN; Nath, SR; Schwarz, DMC; Shao, H; Marin-Argany, M; Di Sanza, C; Giorgetti, E; Yu, ZG; Pieratelli, R; Felli, IC; Brun-Heath, I; García, J; Nebreda, AR; Gestwicki, JE; Lieberman, AP; Salvatella, X
Nature Communications
10
1
3562 -
-
2019
The Expansion of Inosine at the Wobble Position of tRNAs, and Its Role in the Evolution of Proteomes
Rafels-Ybern, A; Torres, AG; Camacho, N; Herencia-Ropero, A; Frigolé, HR; Wulff, TF; Raboteg, M; Bordons, A; Grau-Bove, X; Ruiz-Trillo, I; de Pouplana, LR
Molecular Biology And Evolution
36
4
650 -
662
2019
Evolutionary and functional patterns of shared gene neighbourhood in fungi
Marcet-Houben, M; Gabaldón, T
Nature Microbiology
4
12
2383 -
2392
2019
The mutational footprints of cancer therapies
Pich, O; Muiños, F; Lolkema, MP; Steeghs, N; Gonzalez-Perez, A; Lopez-Bigas, N
Nature Genetics
51
12
1732 -
+
2019
OncodriveCLUSTL: A sequence-based clustering method to identify cancer drivers
Arnedo-Pac, C; Mularoni, L; Muiños, F; Gonzalez-Perez, A; Lopez-Bigas, N
Bioinformatics
35
22
4788 -
4790
2019
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Lindeboom, RGH; Vermeulen, M; Lehner, B; Supek, F
Nature Genetics
51
11
1645 -
+
2019
Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
Aragón, E; Wang, Q; Zou, YL; Morgani, SM; Ruiz, L; Kaczmarska, Z; Su, J; Torner, C; Tian, L; Hu, J; Shu, WP; Agrawal, S; Gomes, T; Márquez, JA; Hadjantonakis, AK; Macias, MJ; Massagué, J
Genes & Development
33
21-22
1506 -
1524
2019
Inducible slc7a7 knockout mouse model recapitulates lysinuric protein intolerance disease
Bodoy, S; Sotillo, F; Espino-Guarch, M; Sperandeo, MP; Ormazabal, A; Zorzano, A; Sebastio, G; Artuch, R; Palacín, M
International Journal Of Molecular Sciences
20
21
5294 -
-
2019
Cellular Senescence: Defining a Path Forward
Gorgoulis, V; Adams, PD; Alimonti, A; Bennett, DC; Bischof, O; Bishop, C; Campisi, J; Collado, M; Evangelou, K; Ferbeyre, G; Gil, J; Hara, E; Krizhanovsky, V; Jurk, D; Maier, AB; Narita, M; Niedernhofer, L; Passos, JF; Robbins, PD; Schmitt, CA; Sedivy, J; Vougas, K; von Zglinicki, T; Zhou, DH; Serrano, M; Demaria, M
Cell
179
4
813 -
827
2019
Top-down proteomics applied to human cerebrospinal fluid
Gay, M; Sánchez-Jiménez, E; Villarreal, L; Vilanova, M; Huguet, R; Arauz-Garofalo, G; Díaz-Lobo, M; López-Ferrer, D; Vilaseca, M
Crispr Knock-Ins In Organoids To Track Tumor Cell Subpopulations
2044
-
193 -
219
2019
A five-level classification system for proteoform identifications
Smith, LM; Thomas, PM; Shortreed, MR; Schaffer, LV; Fellers, RT; Leduc, RD; Tucholski, T; Ge, Y; Agar, JN; Anderson, LC; Chamot-Rooke, J; Gault, J; Loo, JA; Pasa-Tolic, L; Robinson, CV; Schlüter, H; Tsybin, YO; Vilaseca, M; Vizcaíno, JA; Danis, PO; Kelleher, NL
Nature Methods
16
10
939 -
940
2019
Atomic structure of the Epstein-Barr virus portal
Machón, C; Fàbrega-Ferrer, M; Zhou, DM; Cuervo, A; Carrascosa, JL; Stuart, DI; Coll, M
Nature Communications
10
1
3891 -
-
2019
Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
Cuervo, A; Fàbrega-Ferrer, M; Machón, C; Conesa, JJ; Fernández, FJ; Pérez-Luque, R; Pérez-Ruiz, M; Pous, J; Vega, MC; Carrascosa, JL; Coll, M
Nature Communications
10
1
3746 -
-
2019
The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila
Molnar, C; Heinen, JP; Reina, J; Llamazares, S; Palumbo, E; Breschi, A; Gay, M; Villarreal, L; Vilaseca, M; Pollarolo, G; Gonzalez, C
Science Advances
5
8
eaaw7965 -
-
2019
Sidekick Is a Key Component of Tricellular Adherens Junctions that Acts to Resolve Cell Rearrangements
Letizia, A; He, DQ; Astigarraga, S; Colombelli, J; Hatini, V; Llimargas, M; Treisman, JE
Developmental Cell
50
3
313 -
+
2019
Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
Batlle, R; Andrés, E; Gonzalez, L; Llonch, E; Igea, A; Gutierrez-Prat, N; Berenguer-Llergo, A; Nebreda, AR
Nature Communications
10
1
3071 -
-
2019
The chemistry of senescence
Lozono-Torres, B; Estepa-Fernández, A; Rovira, M; Orzáez, M; Serrano, M; Martínez-Máñez, R; Sancenón, F
Nature Reviews Chemistry
3
7
426 -
441
2019
Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage
Murcia, L; Clemente-Ruiz, M; Pierre-Elies, P; Royou, A; Milán, M
Cell Reports
28
1
119 -
+
2019
An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases
Aranda, J; Terrazas, M; Gómez, H; Villegas, N; Orozco, M
Nature Catalysis
2
6
544 -
552
2019
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study
Iacobucci, C; Piotrowski, C; Aebersold, R; Amaral, BC; Andrews, P; Bernfur, K; Borchers, C; Brodie, NI; Bruce, JE; Cao, Y; Chaignepain, S; Chavez, JD; Claverol, S; Cox, J; Davis, T; Degliesposti, G; Dong, MQ; Edinger, N; Emanuelsson, C; Gay, M; Götze, M; Gomes-Neto, F; Gozzo, FC; Gutierrez, C; Haupt, C; Heck, AJR; Herzog, F; Huang, L; Hoopmann,...
Analytical Chemistry
91
11
6953 -
6961
2019
Defining the Independence of the Liver Circadian Clock
Koronowski, KB; Kinouchi, K; Welz, PS; Smith, JG; Zinna, VM; Shi, JJ; Samad, M; Chen, SW; Magnan, CN; Kinchen, JM; Li, W; Baldi, P; Benitah, SA; Sassone-Corsi, P
Cell
177
6
1448 -
+
2019
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
Welz, PS; Zinna, VM; Symeonidi, A; Koronowski, KB; Kinouchi, K; Smith, JG; Guillén, IM; Castellanos, A; Crainiciuc, G; Prats, N; Caballero, JM; Hidalgo, A; Sassone-Corsi, P; Benitah, SA
Cell
177
6
1436 -
+
2019
Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments
Torres, AG; Reina, O; Attolini, CSO; de Pouplana, LR
Proceedings Of The National Academy Of Sciences Of The United States Of America
116
17
8451 -
8456
2019
Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain
Detrez, JR; Maurin, H; Van Kolen, K; Willems, R; Colombelli, J; Lechat, B; Roucourt, B; Van Leuven, F; Baatout, S; Larsen, P; Nuydens, R; Timmermans, JP; De Vos, WH
Neurobiology Of Disease
127
-
398 -
409
2019
Lysosomal trapping of palbociclib and its functional implications
Llanos, S; Megias, D; Blanco-Aparicio, C; Hernández-Encinas, E; Rovira, M; Pietrocola, F; Serrano, M
Oncogene
38
20
3886 -
3902
2019
Highly Enantioselective Iridium-Catalyzed Hydrogenation of 2-Aryl Allyl Phthalimides
Cabré, A; Romagnoli, E; Martínez-Balart, P; Verdaguer, X; Riera, A
Organic Letters
21
23
9709 -
9713
2019
CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression
Cano-Crespo, S; Chillarón, J; Junza, A; Fernández-Miranda, G; García, J; Polte, C; de la Ballina, LR; Ignatova, Z; Yanes, O; Zorzano, A; Attolini, CSO; Palacín, M
Scientific Reports
9
1
14065 -
-
2019
Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
Pittolo, S; Lee, H; Lladó, A; Tosi, S; Bosch, M; Bardia, L; Gómez-Santacana, X; Llebaria, A; Soriano, E; Colombelli, J; Poskanzer, KE; Perea, G; Gorostiza, P
Proceedings Of The National Academy Of Sciences Of The United States Of America
116
27
13680 -
13689
2019
The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry
Terrazas, M; Genna, V; Portella, G; Villegas, N; Sánchez, D; Arnan, C; Pulido-Quetglas, C; Johnson, R; Guigó, R; Brun-Heath, I; Aviñó, A; Eritja, R; Orozco, M
Chem
5
6
1619 -
1631
2019
Autophagy-induced senescence is regulated by p38α signaling
Slobodnyuk, K; Radic, N; Ivanova, S; Llado, A; Trempolec, N; Zorzano, A; Nebreda, AR
Cell Death & Disease
10
-
376 -
-
2019
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Orellana, L; Thorne, AH; Lema, R; Gustavsson, J; Parisian, AD; Hospital, A; Cordeiro, TN; Bernadó, P; Scott, AM; Brun-Heath, I; Lindahl, E; Cavenee, WK; Furnari, FB; Orozco, M
Proceedings Of The National Academy Of Sciences Of The United States Of America
116
20
10009 -
10018
2019
Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
Terré, B; Lewis, M; Gil-Gómez, G; Han, ZY; Lu, H; Aguilera, M; Prats, N; Roy, S; Zhao, HT; Stracker, TH
Development
146
8
dev162628 -
-
2019
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo, A; Topal, B; Kunze, MBA; Aranda, J; Chiesa, G; Mungianu, D; Bernardo-Seisdedos, G; Eftekharzadeh, B; Gairí, M; Pierattelli, R; Felli, IC; Diercks, T; Millet, O; García, J; Orozco, M; Crehuet, R; Lindorff-Larsen, K; Salvatella, X
Nature Communications
10
-
2034 -
-
2019
The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle
Moreno-Moreno, O; Torras-Llort, M; Azorin, F
Nucleic Acids Research
47
7
3395 -
3406
2019
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Errasti-Murugarren, E; Fort, J; Bartoccioni, P; Díaz, L; Pardon, E; Carpena, X; Espino-Guarch, M; Zorzano, A; Ziegler, C; Steyaert, J; Fernández-Recio, J; Fita, I; Palacín, M
Nature Communications
10
-
1807 -
-
2019
Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7
Bartoccioni, P; Fort, J; Zorzano, A; Errasti-Murugarren, E; Palacín, M
Journal Of General Physiology
151
4
505 -
517
2019
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E; Massagué, J
Immunity
50
4
924 -
940
2019
Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit
Picchioni, D; Antolin-Fontes, A; Camacho, N; Schmitz, C; Pons-Pons, A; Rodríguez-Escribà, M; Machallekidou, A; Güler, MN; Siatra, P; Carretero-Junquera, M; Serrano, A; Hovde, SL; Knobel, PA; Novoa, EM; Solà-Vilarrubias, M; Kaguni, LS; Stracker, TH; de Pouplana, LR
Cell Reports
27
1
40 -
+
2019
An In-Depth Look at DNA Crystals through the Prism of Molecular Dynamics Simulations
Kuzmanic, A; Dans, PD; Orozco, M
Chem
5
3
649 -
663
2019
Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics
Colizzi, F; Hospital, A; Zivanovic, S; Orozco, M
Angewandte Chemie (International Ed. Print)
58
12
3759 -
3763
2019