Results about: amino acid transport
One of the functions of the kidney is the tubular re-absorption of solutes, such as amino acids, filtrated in the glomerulus. Several amino acid transporters are involved in this process and when defective they cause primary inherited aminoacidurias (PIA).
Technology can now extend the album of 3D “photos” of membrane proteins, which currently covers 3% of these molecules
30% of human proteins exert their function in cell membranes and more than 50% act on these proteins.
New high-resolution microscopes and 3D calculation programmes are crucial to increase the number of atomic structures available, which currently stands at 440, this figure representing 3% of the estimated 15,000 that exist.
Today sees the start of a three-day conference in Barcelona involving 150 international scientists invited by the BBVA Foundation and IRB Barcelona.
Researchers at IRB Barcelona, BSC, and the University of Bern observe the first structure of a human HAT at low resolution.
HAT amino acid transporters are involved in pathologies such as aminoacidurias, cancer, viral infections and cocaine addiction.
The breakthrough published in the Proceedings of the National Academy of Science USA allows researchers to delve into the functions of HATs and to address the rational drug design of inhibitors.
The study has been partially funded by the European project EDICT (European Drug Initiative on Channels and Transporters), devoted to increasing the number of membrane protein structures available.