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Research

At the forefront of biomedicine

Research publications

TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages
Henriques, Ana; Salvany-Celades, Maria; Nieto, Paula; Palomo-Ponce, Sergio; Sevillano, Marta; Hernando-Momblona, Xavier; Middendorp-Guerra, Emily; Llanses Martinez, Montserrat; Haak, Elisabeth Marjolein; Nieto, Juan; Caratú, Ginevra; Marchese, Domenica; Ruiz Gil, Max; Tosi, Sebastien; Suckert, Theresa; Badia-Ramentol, Jordi; Caballé-Mestres,...
Nature Genetics
2025
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Centonze, Alessia; Roura, Adrià-Jaume; Novillo-Font, Meritxell; Giordano, Cristina; Hernando-Momblona, Xavier; Llanses, Montserrat; Prats, Paula; Sevillano, Marta; Cabot, Débora; Novell, Mireia; Pabst, Gabriel; Andersch, Florian; Cañellas-Socias, Adrià; Zhang, Chong; Giakoumakis, Nikolaos-Nikiforos; Sparks, Hugh; Dunsby, Chris; Colombelli,...
Cancer Discovery
2025
Sex and smoking bias in the selection of somatic mutations in human bladder
Calvet, Ferriol; Blanco Martinez-Illescas, Raquel; Muinos, Ferran; Tretiakova, Maria; Latorre-Esteves, Elena S; Fredrickson, Jeanne; Andrianova, Maria; Pellegrini, Stefano; Huber, Axel Rosendahl; Ramis-Zaldivar, Joan Enric; An, Shuyi Charlotte; Thieme, Elana; Kohrn, Brendan F; Grau, Miguel L; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria; Risques,...
Nature
2025
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
Pellegrini, Stefano; Dove-Estrella, Olivia; Muinos, Ferran; Lopez-Bigas, Nuria; Gonzalez-Perez, Abel
Nucleic Acids Research
53
15
gkaf776 -
2025
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
Scherer, Michael; Singh, Indranil; Braun, Martina Maria; Szu-Tu, Chelsea; Sanchez Sanchez, Pedro; Lindenhofer, Dominik; Jakobsen, Niels Asger; Kardorff, Michael; Nitsch, Lena; Kautz, Pauline; Bianchi, Agostina; Cozzuto, Luca; Beneyto-Calabuig, Sergi; Lareau, Caleb; Satpathy, Ansuman T; Beekman, Renee; Steinmetz, Lars M; Raffel, Simon; Ludwig,...
Nature
643
478 -
487
2025
A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model
Pons-Grífols A; Tarrés-Freixas F; Pérez M; Riveira-Muñoz E; Raïch-Regué D; Perez-Zsolt D; Muñoz-Basagoiti J; Tondelli B; Pradenas E; Izquierdo-Useros N; Capdevila S; Vergara-Alert J; Urrea V; Carrillo J; Ballana E; Forrow S; Clotet B; Segalés J; Trinité B; Blanco J
Mbio
16
5
e0072025 -
2025
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse
Heras-Murillo, Ignacio; Mananes, Diego; Munne, Pablo; Nunez, Vanessa; Herrera, Jessica; Catala-Montoro, Mauro; Alvarez, Maite; del Pozo, Miguel A; Melero, Ignacio; Wculek (#), Stefanie K; Sancho, David (#)
(#) Corresponding author
Nature Communications
16
1
3369 -
2025
Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response
Ricolo, D; Casanova, J; Giannios, P
Science Advances
11
13
eads2086 -
2025
Transcriptional heterogeneity shapes stress-adaptive responses in yeast
Nadal-Ribelles, Mariona; Lieb, Guillaume; Solé, Carme; Matas, Yaima; Szachnowski, Ugo; Andjus, Sara; Quintana, Maria; Romo, Mònica; Herrero, Aitor Gonzalez; Morillon, Antonin; Pelet, Serge; de Nadal, Eulàlia; Posas, Francesc
Nature Communications
16
1
2631 -
2025
Autocrine Wingless constricts the Drosophila embryonic gut by Ca+2-mediated repolarisation of mesoderm cells
Ricolo, D; Tamba, F; Casanova, J
Embo Reports
26
1737 -
1748
2025
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations
Nadal-Ribelles, Mariona; Solé, Carme; Díez-Villanueva, Anna; Stephan-Otto Attolini, Camille; Matas, Yaima; Steinmetz, Lars; de Nadal, Eulàlia; Posas, Francesc
Nature Communications
16
1
2645 -
2025
Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations
Singh, Indranil; Fernandez-Perez, Daniel; Sanchez, Pedro Sanchez; Rodriguez-Fraticelli, Alejo E.
Cell Stem Cell
32
4
564 -
580
2025
Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing
Perucca, Alice; Llonin, Andrea Gomez; Benach, Oriol Mane; Hallopeau, Clement; Rivas, Elisa I; Linares, Jenniffer; Garrido, Marta; Sallent-Aragay, Anna; Golde, Tom; Colombelli, Julien; Dalaka, Eleni; Linacero, Judith; Cazorla, Marina; Galan, Teresa; Pastor Viel, Jordi; Badenas, Xavier; Recort-Bascuas, Alba; Comerma, Laura; Fernandez-Nogueira,...
Nature Communications
16
1
1279 -
2025
Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis
Giroud-Gerbetant, Judith; Sotillo, Fernando; Hernández, Gonzalo; Ruano, Irene; Sebastián, David; Fort, Joana; Sánchez, Mayka; Weiss, Günter; Prats, Neus; Zorzano, Antonio; Palacín, Manuel; Bodoy, Susanna
Molecular Medicine
31
1
29 -
2025
Redox proteomics reveal a role for peroxiredoxinylation in stress protection
Seisenbacher, Gerhard; Nakic, Zrinka Raguz; Borràs, Eva; Sabidó, Eduard; Sauer, Uwe; de Nadal, Eulalia; Posas, Francesc
Cell Reports
44
2
115224 -
2025
H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells
Ramponi, V; Richart, L; Kovatcheva, M; Attolini, CSO; Capellades, J; Lord, AE; Yanes, O; Ficz, G; Serrano, M
Cancer Research
85
1
32 -
51
2025
The conserved lysine residue in transmembrane helix 5 is key for the cytoplasmic gating of the L-amino acid transporters
Fort, Joana; Nicolàs-Aragó, Adrià; Maggi, Luca; Martinez Molledo, Maria; Kapiki, Despoina; Gonzalez-Novoa, Paula; Gómez-Gejo, Patricia; Zijlstra, Niels; Bodoy, Susanna; Pardon, Els; Steyaert, Jan; Llorca, Oscar; Orozco, Modesto; Cordes, Thorben; Palacín, Manuel
Pnas Nexus
4
1
pgae584 -
2025
Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD
Garcia-Cabau C; Bartomeu A; Tesei G; Cheung KC; Pose-Utrilla J; Picó S; Balaceanu A; Duran-Arqué B; Fernández-Alfara M; Martín J; De Pace C; Ruiz-Pérez L; García J; Battaglia G; Lucas JJ; Hervás R; Lindorff-Larsen K; Méndez R; Salvatella X
Nature
637
8045
496 -
503
2025
Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy
Gordaliza-Alaguero, I; Sànchez-Fernàndez-de-Landa, P; Radivojevikj, D; Villarreal, L; Arauz-Garofalo, G; Gay, M; Martinez-Vicente, M; Seco, J; Martín-Malpartida, P; Vilaseca, M; Macías, MJ; Palacin, M; Ivanova, S; Zorzano, A
Autophagy
21
5
957 -
978
2024
TGF-β and RAS jointly unmask primed enhancers to drive metastasis
Lee, Jun Ho; Sánchez-Rivera, Francisco J.; He, Lan; Basnet, Harihar; Chen, Fei Xavier; Spina, Elena; Li, Liangji; Torner, Carles; Chan, Jason E.; Yarlagadda, Dig Vijay Kumar; Park, Jin Suk; Sussman, Carleigh; Rudin, Charles M.; Lowe, Scott W.; Tammela, Tuomas; Macias, Maria J.; Koche, Richard P.; Massagué, Joan
Cell
187
22
6182 -
6199.e29
2024
CDK5RAP2 activates microtubule nucleator γTuRC by facilitating template formation and actin release
Serna, M; Zimmermann, F; Vineethakumari, C; Gonzalez-Rodriguez, N; Llorca, O; Lüders, J
Developmental Cell
59
23
3175 -
3188
2024
Five latent factors underlie response to immunotherapy
Usset, Joseph; Rosendahl Huber, Axel; Andrianova, Maria A.; Batlle, Eduard; Carles, Joan; Cuppen, Edwin; Elez, Elena; Felip, Enriqueta; Gómez-Rey, Marina; Lo Giacco, Deborah; Martinez-Jimenez, Francisco; Muñoz-Couselo, Eva; Siu, Lillian L.; Tabernero, Josep; Vivancos, Ana; Muiños, Ferran; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria
Nature Genetics
56:
2112 -
2120
2024
Comprehensive detection and characterization of human druggable pockets through binding site descriptors
Comajuncosa-Creus, Arnau; Jorba, Guillem; Barril, Xavier; Aloy, Patrick
Nature Communications
15
1
7917 -
2024
Metabolic homeostasis of tissue macrophages across the lifespan
Wculek, Stefanie K. (#); Forisch, Stephan; Miguel, Verónica; Sancho, David (#)
(#) Corresponding author
Trends In Endocrinology And Metabolism
35
9
793 -
808
2024
Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells
López-Polo, V; Maus, M; Zacharioudakis, E; Lafarga, M; Attolini, CSO; Marques, FDM; Kovatcheva, M; Gavathiotis, E; Serrano, M
Nature Communications
15
1
7378 -
2024
Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
Huber, Anne; Allam, Amr H; Dijkstra, Christine; Thiem, Stefan; Huynh, Jennifer; Poh, Ashleigh R; Konecnik, Joshua; Jacob, Saumya P; Busuttil, Rita; Liao, Yang; Chisanga, David; Shi, Wei; Alorro, Mariah G; Forrow, Stephen; Tauriello, Daniele V F; Batlle, Eduard; Boussioutas, Alex; Williams, David S; Buchert, Michael; Ernst, Matthias; Eissmann,...
Cell Reports
43
8
114616 -
2024
Human EWS-FLI protein levels and neomorphic functions show a complex, function-specific dose-response relationship in Drosophila.
Mahnoor S; Molnar C; Velázquez D; Reina J; Llamazares S; Heinen JP; Mora J; Gonzalez C
Open Biology
14
7
240043 -
2024
Harnessing dendritic cell metabolism for healthy ageing: reducing the risk of cardiovascular disease?
Wculek, SK
European Heart Journal
45
27
2355 -
2357
2024
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, I; Bernard, D; Nguyen, K; Ho, G; Morrison, A; Stecula, A; Rosnik, A; O'Sullivan, AM; Davtyan, A; Samudio, B; Thomas, B; Worley, B; Butler, B; Laggner, C; Thayer, D; Moharreri, E; Friedland, G; Truong, H; van den Bedem, H; Ng, HL; Stafford, K; Sarangapani, K; Giesler, K; Ngo, L; Mysinger, M; Ahmed, M; Anthis, NJ; Henriksen, N; Gniewek, P;...
Scientific Reports
14
1
7526 -
2024
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
Mortimer, Thomas; Zinna, Valentina M.; Atalay, Muge; Laudanna, Carmelo; Deryagin, Oleg; Posas, Guillem; Smith, Jacob G.; García-Lara, Elisa; Vaca-Dempere, Mireia; Monteiro de Assis, Leonardo Vinícius; Heyde, Isabel; Koronowski, Kevin B.; Petrus, Paul; Greco, Carolina M.; Forrow, Stephen; Oster, Henrik; Sassone-Corsi, Paolo; Welz, Patrick-Simon;...
Cell Stem Cell
31
6
834 -
849
2024
Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues
Sánchez-Guixé, Mònica; Muiños, Ferran; Pinheiro-Santin, Morena; González-Huici, Víctor; Rodriguez-Hernandez, Carlos J.; Avgustinova, Alexandra; Lavarino, Cinzia; González-Pérez, Abel; Mora, Jaume; López-Bigas, Núria
Cancer Discovery
14
6
953 -
964
2024
Mechanisms of metastatic colorectal cancer
Cañellas-Socias, Adrià; Sancho, Elena; Batlle, Eduard
Nature Reviews Gastroenterology & Hepatology
21
9
609 -
625
2024
TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth
Molnar, Cristina; Heinen, Jan Peter; Reina, Jose; Llamazares, Salud; Palumbo, Emilio; Pollarolo, Giulia; Gonzalez, Cayetano
Embo Reports
25
7
2842 -
2860
2024
Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Demajo, Santiago; Ramis-Zaldivar; Joan Enric, Muiños, Ferran; Grau, Miquel L; Andrianova, Maria; López-Bigas, Núria; González-Pérez, Abel.
Cancer Discovery
14
9
1717 -
1731
2024
Innovating in a bioimaging core through instrument development
Munck, S; De Bo, C; Cawthorne, C; Colombelli, J
Journal Of Microscopy
294
3
319 -
337
2024
Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells
Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C
Nucleic Acids Research
52
6
3375 -
3389
2024
Dendritic cells as orchestrators of anticancer immunity and immunotherapy
Heras-Murillo, I; Adán-Barrientos, I; Galán, M; Wculek, SK (#) ; Sancho, D (#)
(#) Corresponding author
Nature Reviews Clinical Oncology
21
4
257 -
277
2024
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chaib S; López-Domínguez JA; Lalinde-Gutiérrez M; Prats N; Marin I; Boix O; García-Garijo A; Meyer K; Muñoz MI; Aguilera M; Mateo L; Stephan-Otto Attolini C; Llanos S; Pérez-Ramos S; Escorihuela M; Al-Shahrour F; Cash TP; Tchkonia T; Kirkland JL; Abad M; Gros A; Arribas J; Serrano M
Nature Cancer
5
3
448 -
462
2024
Urease-powered nanobots for radionuclide bladder cancer therapy
Simo, C; Serra-Casablancas, M; Hortelao, AC; Di Carlo, V; Guallar-Garrido, S; Plaza-Garcia, S; Rabanal, RM; Ramos-Cabrer, P; Yaguee, B; Aguado, L; Bardia, L; Tosi, S; Gomez-Vallejo, V; Martin, A; Patino, T; Julian, E; Colombelli, J; Llop, J; Sanchez, S
Nature Nanotechnology
19
554 -
564
2024
Hotspot propensity across mutational processes
Arnedo-Pac C, Muiños F, Gonzalez-Perez A, Lopez-Bigas N
Molecular Systems Biology
20
1
6 -
27
2024
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, MA; Gabaldón, T
Nature Microbiology
9
1
284 -
307
2024
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C
Angewandte Chemie (International Ed. Print)
63
12
e202316730 -
e202316730
2024
Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms
Anna Oncins, Roser Zaurin, Houyem Toukabri, Kimberly Quililan, José R Hernández Mora, Magdalena A Karpinska, Erik Wernersson, Alastair Smith, Agostina Bianchi, Leone Albinati, Andrea Rivero, François Serra, Raúl Gómez, Cristina López, Sílvia Beà, Nadia Halidi, Alfonso Valencia, Magda Bienko, A Marieke Oudelaar, Renée Beekman.
bioRxiv 2024.10.07.616925
2024
Protein quality control for improved data reproducibility and reliability
Remans, K.; De Marco, A.; Berrow, N.; Lebendiker, M.; Garcia-Alai, M.; Knauer, S.; Lopez-Mendez, B.; Matagne, A.; Parret, A.; Uebel, S.; Raynal, B.
Acta Crystallographica A-Foundation And Advances
78
a2
e33 -
e33
2023
Identification of ade novomutation inTLK1associated with a neurodevelopmental disorder and immunodeficiency
Villamor-Payà, Marina; Sanchiz-Calvo, María; Smak, Jordann; Pais, Lynn; Sud, Malika; Shankavaram, Uma; Lovgren, Alysia Kern; Austin-Tse, Christina; Ganesh, Vijay S; Gay, Marina; Vilaseca, Marta; Arauz-Garofalo, Gianluca; Palenzuela, Lluís; VanNoy, Grace; O’Donnell-Luria, Anne; Stracker, Travis H.
Medrxiv : The Preprint Server For Health Sciences
2023
MAF amplification licenses ERa through epigenetic remodelling to drive breast cancer metastasis
Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballè, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR
Nature Cell Biology
25
12
1833 -
1847
2023
Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity
Marin, I; Boix, O; Garcia-Garijo, A; Sirois, I; Caballe, A; Zarzuela, E; Ruano, I; Attolini, CSO; Prats, N; López-Domínguez, JA; Kovatcheva, M; Garralda, E; Muñoz, J; Caron, E; Abad, M; Gros, A; Pietrocola, F; Serrano, M
Cancer Discovery
13
2
410 -
431
2023
Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
Pous, J; Baginski, B; Martin-Malpartida, P; González, L; Scarpa, M; Aragon, E; Ruiz, L; Mees, RA; Iglesias-Fernández, J; Orozco, M; Nebreda, AR; Macias, MJ
Nature Communications
14
1
7920 -
2023