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Growth Control and Cancer Metastasis
Imatge
Group Leader
Telephone:
+34 93 40 39959

ICREA Research Professor

Imatge
ICREA

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Research information

Background

Intricate signalling networks control cell division, differentiation, movement, organization and death. Understanding how cells read and transform these signals into changes in cell behaviour is a major research focus of our group. Cancer cells disobey these signals during tumour progression and metastasis. Metastasis is the final step in 90% of all fatal solid tumours.  It is therefore a grave public health problem and consequently a field of considerable pharmaceutical interest.

Research interests

Growth Control and Cancer Metastasis

Our research centres on how growth factors, signalling pathways, and gene expression programmes control normal cell proliferation and cancer cell metastasis.

We study the ways in which cancer cells evade tumour suppressor mechanisms and engage in metastatic behaviour. We focus on a cytostatic programme involving the transcriptional activation of cell cycle inhibitors and the transcriptional repression of growth-promoting and anti-differentiation factors. Furthermore, we examine how tumour cells evade these gene responses in order to pursue metastatic behaviour. By combining in vivo selection of human metastatic cells, transcriptomic profiling and functional testing, we identify genes that selectively mediate breast metastasis to specific organs. Gene transfer techniques and RNAi-mediated gene silencing are used to functionally validate candidate genes. We are encouraged by the recent validation of these findings in clinical samples. Several of these genes encode products that are susceptible to therapeutic targeting.

Selected publications

Urosevic, Jelena; Teresa Blasco, Maria; Llorente, Alicia; Bellmunt, Anna; Berenguer-Llergo, Antoni; Guiu, Marc; Canellas, Adria; Fernandez, Esther; Burkov, Ivan; Clapes, Maria; Cartana, Mireia; Figueras-Puig, Cristina; Batlle, Eduard; Nebreda, Angel R.; Gomis, Roger R.;
Cancer Research
80
(21 )
4668 -
4680
(2021)
Gawrzak S, Rinaldi L, Gregorio S, Arenas EJ, Salvador F, Urosevic J, Figueras-Puig C, Rojo F, Del Barco Barrantes I, Cejalvo JM, Palafox M, Guiu M, Berenguer-Llergo A, Symeonidi A, Bellmunt A, Kalafatovic D, Arnal-Estapé A, Fernández E, Müllauer B, Groeneveld R, Slobodnyuk K, Stephan-Otto Attolini C, Saura C, Arribas J, Cortes J, Rovira A, Muñoz M, Lluch A, Serra V, Albanell J, Prat A, Nebreda AR, Benitah SA, Gomis RR
Nature Cell Biology
20
(8 )
1 -
990
(2018)
Gawrzak S; Rinaldi L; Gregorio S; Arenas EJ; Salvador F; Urosevic J; Figueras-Puig C; Rojo F; Del Barco Barrantes I; Cejalvo JM; Palafox M; Guiu M; Berenguer-Llergo A; Symeonidi A; Bellmunt A; Kalafatovic D; Arnal-Estapé A; Fernández E; Müllauer B; Groeneveld R; Slobodnyuk K; Stephan-Otto Attolini C; Saura C; Arribas J; Cortes J; Rovira A; Muñoz M; Lluch A; Serra V; Albanell J; Prat A; Nebreda AR; Benitah SA; Gomis RR
Nature Cell Biology
20
(2 )
211 -
221
(2018)
Coleman R; Hall A; Albanell J; Hanby A; Bell R; Cameron D; Dodwell D; Marshall H; Jean-Mairet J; Tercero JC; Rojo F; Gregory W; Gomis RR
Lancet Oncology
18
(11 )
1543 -
1552
(2017)
Slebe F; Rojo F; Vinaixa M; García-Rocha M; Testoni G; Guiu M; Planet E; Samino S; Arenas E; Beltran A; Rovira A; Lluch A; Salvatella X; Yanes O; Albanell J; Guinovart J; Gomis R
Nature Communications
7
(11199 )
11199 -
(2016)
Oller-Salvia B; Sánchez-Navarro M; Ciudad S; Guiu M; Arranz-Gibert P; Garcia C; Gomis R; Cecchelli R; García J; Giralt E; Teixidõ M
Angewandte Chemie (International Ed. Print)
55
(2 )
572 -
575
(2016)
Pavlovic, Milica; Arnal-Estape, Anna; Rojo, Federico; Bellmunt, Anna; Tarragona, Maria; Guiu, Marc; Planet, Evarist; Garcia-Albeniz, Xabier; Morales, Monica; Urosevic, Jelena; Gawrzak, Sylwia; Rovira, Ana; Prat, Aleix; Nonell, Lara; Lluch, Ana; Jean-Mairet, Joel; Coleman, Robert; Albanell, Joan; Gomis, Roger R
Jnci-Journal Of The National Cancer Institute
107
(12 )
djv256 -
(2015)
Urosevic, Jelena; Garcia-Albeniz, Xabier; Planet, Evarist; Real, Sebastian; Cespedes, Maria Virtudes; Guiu, Marc; Fernandez, Esther; Bellmunt, Anna; Gawrzak, Sylwia; Pavlovic, Milica; Mangues, Ramon; Dolado, Ignacio; Barriga, Francisco M; Nadal, Cristina; Kemeny, Nancy; Batlle, Eduard; Nebreda, Angel R; Gomis, Roger R
Nature Cell Biology
16
(7 )
685 -
694
(2014)
Morales M; Arenas EJ; Urosevic J; Guiu M; Fernández E; Planet E; Fenwick RB; Fernández-Ruiz S; Salvatella X; Reverter D; Carracedo A; Massagué J; Gomis RR
Embo Molecular Medicine
6
(7 )
865 -
881
(2014)

Projects

"Mecanismos de latencia metastática en cancer de mama" cofinanciado por el Ministerio de Economia y Competitividad y por el Fondo Europeo de Desarrollo Regional (FEDER). Referencia: SAF2016-76008-R (MINECO/FEDER, UE)

Gobierno de españa
European union

"LIPID targeting in breast cancer" Fondo Europeo de Desarrollo Regional (FEDER) de la Unión Europea en el marco del Programa operativo FEDER de Catalunya 2014-2020. Referencia: 2016 PROD 00086

AGAUR
Secretaria d'Universitas i Recerca
European union

"Metastasis Cell Fate Mapping" La Caixa Foundation under the agreement LCF/PR/HR17/52150014

La Caixa Foundation

"Vulnerabilities of Tumour and Stroma Interactions in Castration-Naïve Metastatic Prostate Cancer" Acrónimo: PROSTARGET de la Asociación Española contra el Cáncer (AECC).

AECC

Group members

Group Leader
Lab Manager
Postdoctoral Fellow
Postdoctoral Fellow
PhD Student
PhD Student
Postdoctoral Fellow
Visiting Student

Group News

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