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Research

At the forefront of biomedicine

Institutional selected publications

TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages
Henriques, Ana; Salvany-Celades, Maria; Nieto, Paula; Palomo-Ponce, Sergio; Sevillano, Marta; Hernando-Momblona, Xavier; Middendorp-Guerra, Emily; Llanses Martinez, Montserrat; Haak, Elisabeth Marjolein; Nieto, Juan; Caratu, Ginevra; Marchese, Domenica; Ruiz Gil, Max; Tosi, Sebastien; Suckert, Theresa; Badia-Ramentol, Jordi; Caballe-Mestres,...
Nature Genetics,
53
3050
- 3065
(2025)
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Centonze, Alessia; Roura, Adrià-Jaume; Novillo-Font, Meritxell; Giordano, Cristina; Hernando-Momblona, Xavier; Llanses, Montserrat; Prats, Paula; Sevillano, Marta; Cabot, Débora; Novell, Mireia; Pabst, Gabriel; Andersch, Florian; Cañellas-Socias, Adrià; Zhang, Chong; Giakoumakis, Nikolaos-Nikiforos; Sparks, Hugh; Dunsby, Chris; Colombelli,...
Cancer Discovery,
(2025)
Sex and smoking bias in the selection of somatic mutations in human bladder
Calvet, Ferriol; Blanco Martinez-Illescas, Raquel; Muinos, Ferran; Tretiakova, Maria; Latorre-Esteves, Elena S; Fredrickson, Jeanne; Andrianova, Maria; Pellegrini, Stefano; Huber, Axel Rosendahl; Ramis-Zaldivar, Joan Enric; An, Shuyi Charlotte; Thieme, Elana; Kohrn, Brendan F; Grau, Miguel L; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria; Risques,...
Nature,
647
436
- 444
(2025)
Spatiotemporal T-cell tracking for personalized T-cell receptor T-cell therapy designs in childhood cancer
Sentis, I; Melero, J L; Cebria-Xart, A; Grzelak, M; Soto, M; Michel, A; Rovira, Q; Rodriguez-Hernandez, C J; Caratu, G; Urpi, A; Sauvage, C; Mendizabal-Sasieta, A; Maspero, D; Lavarino, C E; Pascual-Reguant, A; Heredia, A Castaneda; Perez, J P Munoz; Mora, J; Harari, A; Nieto, J C; Avgustinova, A; Heyn, H
Annals Of Oncology,
36
(9)
1096
- 1106
(2025)
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue
Sanchez-Feutrie, Manuela; Romero, Montserrat; Veiga, Sonia R; Borras-Ferre, Nuria; Berrow, Nick; Rafols, Martina; Gimenez, Noemi; Rodgers-Furones, Andrea; Sabate-Perez, Alba; Rodriguez Perez, Angela; Cataldo, Luis Rodrigo; Burghardt, Hans; Sebastian, David; Plana, Natalia; Hernandez, Vanessa; Alcaide, Laura Isabel; Reina, Oscar; Monte, Maria J;...
Nature Communications,
16
(1)
7033
(2025)
DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy
Khalil, Ahmed; Supek, Fran
Nature Communications,
16
(1)
4209
(2025)
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
Scherer, Michael; Singh, Indranil; Braun, Martina Maria; Szu-Tu, Chelsea; Sanchez Sanchez, Pedro; Lindenhofer, Dominik; Jakobsen, Niels Asger; Kardorff, Michael; Nitsch, Lena; Kautz, Pauline; Bianchi, Agostina; Cozzuto, Luca; Beneyto-Calabuig, Sergi; Lareau, Caleb; Satpathy, Ansuman T; Beekman, Renee; Steinmetz, Lars M; Raffel, Simon; Ludwig,...
Nature,
643
478
- 487
(2025)
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse
Heras-Murillo, Ignacio; Mananes, Diego; Munne, Pablo; Nunez, Vanessa; Herrera, Jessica; Catala-Montoro, Mauro; Alvarez, Maite; del Pozo, Miguel A; Melero, Ignacio; Wculek (#), Stefanie K; Sancho, David (#)
(#) Corresponding author
Nature Communications,
16
(1)
3369
(2025)
Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response
Ricolo, D; Casanova, J; Giannios, P
Science Advances,
11
(13)
eads2086
(2025)
Transcriptional heterogeneity shapes stress-adaptive responses in yeast
Nadal-Ribelles, Mariona; Lieb, Guillaume; Solé, Carme; Matas, Yaima; Szachnowski, Ugo; Andjus, Sara; Quintana, Maria; Romo, Mònica; Herrero, Aitor Gonzalez; Morillon, Antonin; Pelet, Serge; de Nadal, Eulàlia; Posas, Francesc
Nature Communications,
16
(1)
2631
(2025)
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations
Nadal-Ribelles, Mariona; Solé, Carme; Díez-Villanueva, Anna; Stephan-Otto Attolini, Camille; Matas, Yaima; Steinmetz, Lars; de Nadal, Eulàlia; Posas, Francesc
Nature Communications,
16
(1)
2645
(2025)
Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations
Singh, Indranil; Fernandez-Perez, Daniel; Sanchez, Pedro Sanchez; Rodriguez-Fraticelli, Alejo E.
Cell Stem Cell,
32
(4)
564
- 580
(2025)
Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD
Garcia-Cabau C; Bartomeu A; Tesei G; Cheung KC; Pose-Utrilla J; Picó S; Balaceanu A; Duran-Arqué B; Fernández-Alfara M; Martín J; De Pace C; Ruiz-Pérez L; García J; Battaglia G; Lucas JJ; Hervás R; Lindorff-Larsen K; Méndez R; Salvatella X
Nature,
637
(8045)
496
- 503
(2025)
Five latent factors underlie response to immunotherapy
Usset, Joseph; Rosendahl Huber, Axel; Andrianova, Maria A.; Batlle, Eduard; Carles, Joan; Cuppen, Edwin; Elez, Elena; Felip, Enriqueta; Gómez-Rey, Marina; Lo Giacco, Deborah; Martinez-Jimenez, Francisco; Muñoz-Couselo, Eva; Siu, Lillian L.; Tabernero, Josep; Vivancos, Ana; Muiños, Ferran; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria
Nature Genetics,
56:
2112
- 2120
(2024)
Comprehensive detection and characterization of human druggable pockets through binding site descriptors
Comajuncosa-Creus, Arnau; Jorba, Guillem; Barril, Xavier; Aloy, Patrick
Nature Communications,
15
(1)
7917
(2024)
Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells
López-Polo, V; Maus, M; Zacharioudakis, E; Lafarga, M; Attolini, CSO; Marques, FDM; Kovatcheva, M; Gavathiotis, E; Serrano, M
Nature Communications,
15
(1)
7378
(2024)
Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules
Toledano, Ignasi; Supek, Fran; Lehner, Ben
Nature Genetics,
56
1914
- 1924
(2024)
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Besedina, Elizaveta; Supek, Fran
Nature Communications,
15
6139
(2024)
An integrated machine-learning model to predict nucleosome architecture
Sala, A; Labrador, M; Buitrago, D; De Jorge, P; Battistini, F; Heath, IB; Orozco, M
Nucleic Acids Research,
52
(17)
10132
- 10143
(2024)
Formation of left-handed helices by C2′-fluorinated nucleic acids under physiological salt conditions
El-Khoury, Roberto; Cabrero, Cristina; Movilla, Santiago; Kaur, Harneesh; Friedland, David; Dominguez, Arnau; Thorpe, James D; Roman, Morgane; Orozco, Modesto; Gonzalez, Carlos; Damha, Masad J
Nucleic Acids Research,
52
(13)
7414
- 7428
(2024)
CGeNArate: a sequence-dependent coarse-grained model of DNA for accurate atomistic MD simulations of kb-long duplexes
Farre-Gil, David; Arcon, Juan Pablo; Laughton, Charles A; Orozco, Modesto
Nucleic Acids Research,
52
(12)
6791
- 6801
(2024)
Brain-muscle communication prevents muscle aging by maintaining daily physiology
Kumar, Arun; Vaca-Dempere, Mireia; Mortimer, Thomas; Deryagin, Oleg; Smith, Jacob G.; Petrus, Paul; Koronowski, Kevin B.; Greco, Carolina M.; Segalés, Jessica; Andrés, Eva; Lukesova, Vera; Zinna, Valentina M.; Welz, Patrick-Simon; Serrano, Antonio L.; Perdiguero, Eusebio; Sassone-Corsi, Paolo; Benitah, Salvador Aznar; Muñoz-Cánoves, Pura
Science,
384
(6695)
563
- 572
(2024)
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
Mortimer, Thomas; Zinna, Valentina M.; Atalay, Muge; Laudanna, Carmelo; Deryagin, Oleg; Posas, Guillem; Smith, Jacob G.; García-Lara, Elisa; Vaca-Dempere, Mireia; Monteiro de Assis, Leonardo Vinícius; Heyde, Isabel; Koronowski, Kevin B.; Petrus, Paul; Greco, Carolina M.; Forrow, Stephen; Oster, Henrik; Sassone-Corsi, Paolo; Welz, Patrick-Simon;...
Cell Stem Cell,
31
(6)
834
- 849
(2024)
Cyclometallated Imides as Templates for the H‐Bond Directed Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Methyl, N‐Alkyl and N‐Aryl Imines
Wen, Yisong; Fernández‐Sabaté, Marc; Lledós, Agustí; Sciortino, Giuseppe; Eills, James; Marco‐Rius, Irene; Riera, Antoni; Verdaguer, Xavier
Angewandte Chemie,
63
(26)
e202404955
(2024)
Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues
Sánchez-Guixé, Mònica; Muiños, Ferran; Pinheiro-Santin, Morena; González-Huici, Víctor; Rodriguez-Hernandez, Carlos J.; Avgustinova, Alexandra; Lavarino, Cinzia; González-Pérez, Abel; Mora, Jaume; López-Bigas, Núria
Cancer Discovery,
14
(6)
953
- 964
(2024)
Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Demajo, Santiago; Ramis-Zaldivar; Joan Enric, Muiños, Ferran; Grau, Miquel L; Andrianova, Maria; López-Bigas, Núria; González-Pérez, Abel.
Cancer Discovery,
14
(9)
1717
- 1731
(2024)
Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter
Rullo-Tubau, Josep; Martinez-Molledo, Maria; Bartoccioni, Paola; Puch-Giner, Ignasi; Arias, Angela; Saen-Oon, Suwipa; Stephan-Otto Attolini, Camille; Artuch, Rafael; Diaz, Lucia; Guallar, Victor; Errasti-Murugarren, Ekaitz; Palacin, Manuel; Llorca, Oscar
Nature Communications,
15
(1)
2986
(2024)
Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation
Mas-Ponte, D; Supek, F
Nucleic Acids Research,
52
(8)
4393
- 4408
(2024)
The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization
Puerto, M; Shukla, M; Bujosa, P; Pérez-Roldán, J; Torràs-Llort, M; Tamirisa, S; Carbonell, A; Solé, C; Puspo, JA; Cummings, CT; de Nadal, E; Posas, F; Azorín, F; Rowley, MJ
Nucleic Acids Research,
52
(10)
5596
- 5609
(2024)
Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells
Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C
Nucleic Acids Research,
52
(6)
3375
- 3389
(2024)
PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy
Lopez-Dominguez, JA; Chaib, S; Serrano, M
Nature Cancer,
5
(3)
382
- 383
(2024)
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chaib S; López-Domínguez JA; Lalinde-Gutiérrez M; Prats N; Marin I; Boix O; García-Garijo A; Meyer K; Muñoz MI; Aguilera M; Mateo L; Stephan-Otto Attolini C; Llanos S; Pérez-Ramos S; Escorihuela M; Al-Shahrour F; Cash TP; Tchkonia T; Kirkland JL; Abad M; Gros A; Arribas J; Serrano M
Nature Cancer,
5
(3)
448
- 462
(2024)
Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers
Salvadores, M; Supek, F
Nature Cancer,
5
(2)
330
- 346
(2024)
Mucosal TLR5 activation controls healthspan and longevity
Lim, JS; Jeon, EJ; Go, HS; Kim, HJ; Kim, KY; Nguyen, TQT; Lee, DY; Kim, KS; Pietrocola, F; Hong, SH; Lee, SE; Kim, KS; Park, TS; Choi, DH; Jeong, YJ; Park, JH; Kim, HS; Min, JJ; Kim, YS; Park, JT; Cho, JH; Lee, GW; Lee, JH; Choy, HE; Park, SC; Lee, CH; Rhee, JH; Serrano, M; Cho, KA
Nature Communications,
15
(1)
46
- 46
(2024)
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, MA; Gabaldón, T
Nature Microbiology,
9
(1)
284
- 307
(2024)
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C
Angewandte Chemie (International Ed. Print),
63
(12)
e202316730
- e202316730
(2024)
A new paradigm for molecular dynamics databases: the COVID-19 database, the legacy of a titanic community effort
Beltrán, D; Hospital, A; Gelpi, JL; Orozco, M
Nucleic Acids Research,
52
(D1)
D393
- D403
(2024)
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Chen, HA; Ho, YJ; Mezzadra, R; Adrover, JM; Smolkin, R; Zhu, CY; Woess, K; Bernstein, N; Schmitt, G; Fong, LD; Luan, W; Wuest, A; Tian, S; Li, X; Broderick, C; Hendrickson, RC; Egeblad, M; Chen, ZH; Alonso-Curbelo, D; Lowe, SW
Cancer Discovery,
13
(2)
432
- 453
(2023)
MAF amplification licenses ERa through epigenetic remodelling to drive breast cancer metastasis
Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballè, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR
Nature Cell Biology,
25
(12)
1833
- 1847
(2023)
Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity
Marin, I; Boix, O; Garcia-Garijo, A; Sirois, I; Caballe, A; Zarzuela, E; Ruano, I; Attolini, CSO; Prats, N; López-Domínguez, JA; Kovatcheva, M; Garralda, E; Muñoz, J; Caron, E; Abad, M; Gros, A; Pietrocola, F; Serrano, M
Cancer Discovery,
13
(2)
410
- 431
(2023)
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M
Nature Metabolism,
5
(11)
1911
- 1930
(2023)
A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing
Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M
Nature Cell Biology,
25
(11)
1590
- 1599
(2023)
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L
Science,
380
(6651)
eadh9351
- eadh9351
(2023)
Targeting lymphoid-derived IL-17 signaling to delay skin aging
Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA
Nature Aging,
3
(6)
688
(2023)
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR
Nature Communications,
14
(1)
3318
(2023)