Institutional selected publications

A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations

Nadal-Ribelles, Mariona; Solé, Carme; Díez-Villanueva, Anna; Stephan-Otto Attolini, Camille; Matas, Yaima; Steinmetz, Lars; de Nadal, Eulàlia; Posas, Francesc

Nature Communications

(1 )

2645 -

(2025)

Five latent factors underlie response to immunotherapy

Usset, Joseph; Rosendahl Huber, Axel; Andrianova, Maria A.; Batlle, Eduard; Carles, Joan; Cuppen, Edwin; Elez, Elena; Felip, Enriqueta; Gómez-Rey, Marina; Lo Giacco, Deborah; Martinez-Jimenez, Francisco; Muñoz-Couselo, Eva; Siu, Lillian L.; Tabernero, Josep; Vivancos, Ana; Muiños, Ferran; Gonzalez-Perez, Abel; Lopez-Bigas, Nuria

Nature Genetics

56:

(- )

2112 -

2120

(2024)

Comprehensive detection and characterization of human druggable pockets through binding site descriptors

Comajuncosa-Creus, Arnau; Jorba, Guillem; Barril, Xavier; Aloy, Patrick

Nature Communications

(1 )

7917 -

(2024)

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

López-Polo, V; Maus, M; Zacharioudakis, E; Lafarga, M; Attolini, CSO; Marques, FDM; Kovatcheva, M; Gavathiotis, E; Serrano, M

Nature Communications

(1 )

7378 -

(2024)

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Toledano, Ignasi; Supek, Fran; Lehner, Ben

Nature Genetics

(- )

- -

(2024)

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations

Besedina, Elizaveta; Supek, Fran

Nature Communications

(1 )

- -

(2024)

An integrated machine-learning model to predict nucleosome architecture

Sala, A; Labrador, M; Buitrago, D; De Jorge, P; Battistini, F; Heath, IB; Orozco, M

Nucleic Acids Research

(17 )

10132 -

10143

(2024)

Formation of left-handed helices by C2′-fluorinated nucleic acids under physiological salt conditions

El-Khoury, Roberto; Cabrero, Cristina; Movilla, Santiago; Kaur, Harneesh; Friedland, David; Dominguez, Arnau; Thorpe, James D; Roman, Morgane; Orozco, Modesto; Gonzalez, Carlos; Damha, Masad J

Nucleic Acids Research

(13 )

7414 -

7428

(2024)

CGeNArate: a sequence-dependent coarse-grained model of DNA for accurate atomistic MD simulations of kb-long duplexes

Farre-Gil, David; Arcon, Juan Pablo; Laughton, Charles A; Orozco, Modesto

Nucleic Acids Research

(12 )

6791 -

6801

(2024)

Brain-muscle communication prevents muscle aging by maintaining daily physiology

Kumar, Arun; Vaca-Dempere, Mireia; Mortimer, Thomas; Deryagin, Oleg; Smith, Jacob G.; Petrus, Paul; Koronowski, Kevin B.; Greco, Carolina M.; Segalés, Jessica; Andrés, Eva; Lukesova, Vera; Zinna, Valentina M.; Welz, Patrick-Simon; Serrano, Antonio L.; Perdiguero, Eusebio; Sassone-Corsi, Paolo; Benitah, Salvador Aznar; Muñoz-Cánoves, Pura

Science

384

(6695 )

563 -

572

(2024)

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

Mortimer, Thomas; Zinna, Valentina M.; Atalay, Muge; Laudanna, Carmelo; Deryagin, Oleg; Posas, Guillem; Smith, Jacob G.; García-Lara, Elisa; Vaca-Dempere, Mireia; Monteiro de Assis, Leonardo Vinícius; Heyde, Isabel; Koronowski, Kevin B.; Petrus, Paul; Greco, Carolina M.; Forrow, Stephen; Oster, Henrik; Sassone-Corsi, Paolo; Welz, Patrick-Simon;...

Cell Stem Cell

(6 )

834 -

849

(2024)

Cyclometallated Imides as Templates for the H‐Bond Directed Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Methyl, N‐Alkyl and N‐Aryl Imines

Wen, Yisong; Fernández‐Sabaté, Marc; Lledós, Agustí; Sciortino, Giuseppe; Eills, James; Marco‐Rius, Irene; Riera, Antoni; Verdaguer, Xavier

Angewandte Chemie

(26 )

e202404955 -

(2024)

Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues

Sánchez-Guixé, Mònica; Muiños, Ferran; Pinheiro-Santin, Morena; González-Huici, Víctor; Rodriguez-Hernandez, Carlos J.; Avgustinova, Alexandra; Lavarino, Cinzia; González-Pérez, Abel; Mora, Jaume; López-Bigas, Núria

Cancer Discovery

(- )

OF1 -

OF12

(2024)

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis

Demajo, Santiago; Ramis-Zaldivar; Joan Enric, Muiños, Ferran; Grau, Miquel L; Andrianova, Maria; López-Bigas, Núria; González-Pérez, Abel.

Cancer Discovery

(9 )

1717 -

1731

(2024)

Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter

Rullo-Tubau, Josep; Martinez-Molledo, Maria; Bartoccioni, Paola; Puch-Giner, Ignasi; Arias, Angela; Saen-Oon, Suwipa; Stephan-Otto Attolini, Camille; Artuch, Rafael; Diaz, Lucia; Guallar, Victor; Errasti-Murugarren, Ekaitz; Palacin, Manuel; Llorca, Oscar

Nature Communications

(1 )

2986 -

(2024)

Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation

Mas-Ponte, D; Supek, F

Nucleic Acids Research

(8 )

4393 -

4408

(2024)

The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization

Puerto, M; Shukla, M; Bujosa, P; Pérez-Roldán, J; Torràs-Llort, M; Tamirisa, S; Carbonell, A; Solé, C; Puspo, JA; Cummings, CT; de Nadal, E; Posas, F; Azorín, F; Rowley, MJ

Nucleic Acids Research

(10 )

5596 -

5609

(2024)

Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells

Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C

Nucleic Acids Research

(6 )

3375 -

3389

(2024)

PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy

Lopez-Dominguez, JA; Chaib, S; Serrano, M

Nature Cancer

(3 )

382 -

383

(2024)

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chaib S; López-Domínguez JA; Lalinde-Gutiérrez M; Prats N; Marin I; Boix O; García-Garijo A; Meyer K; Muñoz MI; Aguilera M; Mateo L; Stephan-Otto Attolini C; Llanos S; Pérez-Ramos S; Escorihuela M; Al-Shahrour F; Cash TP; Tchkonia T; Kirkland JL; Abad M; Gros A; Arribas J; Serrano M

Nature Cancer

(3 )

448 -

462

(2024)

Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers

Salvadores, M; Supek, F

Nature Cancer

(2 )

330 -

346

(2024)

Mucosal TLR5 activation controls healthspan and longevity

Lim, JS; Jeon, EJ; Go, HS; Kim, HJ; Kim, KY; Nguyen, TQT; Lee, DY; Kim, KS; Pietrocola, F; Hong, SH; Lee, SE; Kim, KS; Park, TS; Choi, DH; Jeong, YJ; Park, JH; Kim, HS; Min, JJ; Kim, YS; Park, JT; Cho, JH; Lee, GW; Lee, JH; Choy, HE; Park, SC; Lee, CH; Rhee, JH; Serrano, M; Cho, KA

Nature Communications

(1 )

46 -

(2024)

Recent gene selection and drug resistance underscore clinical adaptation across Candida species

Schikora-Tamarit, MA; Gabaldón, T

Nature Microbiology

(1 )

284 -

307

(2024)

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders

Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C

Angewandte Chemie (International Ed. Print)

(12 )

e202316730 -

e202316730

(2024)

A new paradigm for molecular dynamics databases: the COVID-19 database, the legacy of a titanic community effort

Beltrán, D; Hospital, A; Gelpi, JL; Orozco, M

Nucleic Acids Research

(D1 )

D393 -

D403

(2024)

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

Chen, HA; Ho, YJ; Mezzadra, R; Adrover, JM; Smolkin, R; Zhu, CY; Woess, K; Bernstein, N; Schmitt, G; Fong, LD; Luan, W; Wuest, A; Tian, S; Li, X; Broderick, C; Hendrickson, RC; Egeblad, M; Chen, ZH; Alonso-Curbelo, D; Lowe, SW

Cancer Discovery

(2 )

432 -

453

(2023)

MAF amplification licenses ERa through epigenetic remodelling to drive breast cancer metastasis

Llorente, A; Blasco, MT; Espuny, I; Guiu, M; Ballaré, C; Blanco, E; Caballè, A; Bellmunt, A; Salvador, F; Morales, A; Nuñez, M; Loren, G; Imbastari, F; Fidalgo, M; Figueras-Puig, C; Gibler, P; Graupera, M; Monteiro, F; Riera, A; Holen, I; Avgustinova, A; Di Croce, L; Gomis, RR

Nature Cell Biology

(12 )

1833 -

1847

(2023)

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Marin, I; Boix, O; Garcia-Garijo, A; Sirois, I; Caballe, A; Zarzuela, E; Ruano, I; Attolini, CSO; Prats, N; López-Domínguez, JA; Kovatcheva, M; Garralda, E; Muñoz, J; Caron, E; Abad, M; Gros, A; Pietrocola, F; Serrano, M

Cancer Discovery

(2 )

410 -

431

(2023)

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M

Nature Metabolism

(11 )

1911 -

1930

(2023)

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing

Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M

Nature Cell Biology

(11 )

1590 -

1599

(2023)

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L

Science

380

(6651 )

eadh9351 -

eadh9351

(2023)

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA

Nature Aging

(6 )

688 -

(2023)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR

Nature Communications

(1 )

3318 -

(2023)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M

Nucleic Acids Research

(10 )

4713 -

4725

(2023)

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D

Science

380

(6645 )

597 -

(2023)

López-Güell, K; Battistini, F; Orozco, M

Nucleic Acids Research

(6 )

2633 -

2640

(2023)

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress

Fernández-Alfara, M; Sibilio, A; Martin, J; Uxó, ET; Malumbres, M; Alcalde, V; Chanes, V; Cañellas-Socias, A; Palomo-Ponce, S; Batlle, E; Méndez, R

Embo Journal

(9 )

e111494 -

(2023)

Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG

Ali, A; Vineethakumari, C; Lacasa, C; Lüders, J

Nature Communications

(1 )

289 -

(2023)

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis

Domingo-Muelas, A; Duart-Abadia, P; Morante-Redolat, JM; Jordán-Pla, A; Belenguer, G; Fabra-Beser, J; Paniagua-Herranz, L; Pérez-Villalba, A; Alvarez-Varela, A; Barriga, FM; Gil-Sanz, C; Ortega, F; Batlle, E; Fariñas, I

Nature Communications

(1 )

373 -

(2023)

Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein

Machón, C; Ruiz-Masó, JA; Amodio, J; Boer, DR; Bordanaba-Ruiseco, L; Bury, K; Konieczny, I; del Solar, G; Coll, M

Nucleic Acids Research

(3 )

1458 -

1472

(2023)

Hallmarks of aging: An expanding universe

López-Otin, C; Blasco, MA; Partridge, L; Serrano, M; Kroemer, G

Cell

186

(2 )

243 -

278

(2023)

Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

Irazoki, A; Gordaliza-Alaguero, I; Frank, E; Giakoumakis, NN; Seco, J; Palacín, M; Guma, A; Sylow, L; Sebastián, D; Zorzano, A

Nature Communications

(1 )

108 -

(2023)

Implementing re-configurable biological computation with distributed multicellular consortia

Canadell, D; Ortiz-Vaquerizas, N; Mogas-Diez, S; de Nadal, E; Macia, J; Posas, F

Nucleic Acids Research

(21 )

12578 -

12595

(2022)

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X;...

Nature

611

(7936 )

603 -

613

(2022)

The role of lipids in cancer progression and metastasis

Martin-Perez, M; Urdiroz-Urricelqui, U; Bigas, C; Benitah, SA

Cell Metabolism

(11 )

1675 -

1699

(2022)