Institutional selected publications

Overcoming TGF beta-mediated immune evasion in cancer

Tauriello, DVF; Sancho, E; Batlle, E

Nature Reviews Cancer

(1 )

25 -

(2021)

The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA

Vera-Otarola, J; Castillo-Vargas, E; Angulo, J; Barriga, FM; Batlle, E; Lopez-Lastra, M

Plos Pathogens

(9 )

e1009931 -

(2021)

In silico saturation mutagenesis of cancer genes

Muiños F; Martínez-Jiménez F; Pich O; Gonzalez-Perez A; Lopez-Bigas N

Nature

596

(7872 )

428 -

(2021)

Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

Joy, J; Barrio, L; Santos-Tapia, C; Romao, D; Giakoumakis, NN; Clemente-Ruiz, M; Milan, M

Developmental Cell

(14 )

2043 -

(2021)

Bioactivity descriptors for uncharacterized chemical compounds

Bertoni M; Duran-Frigola M; Badia-i-Mompel P; Pauls E; Orozco-Ruiz M; Guitart-Pla O; Alcalde V; Diaz VM; Berenguer-Llergo A; Brun-Heath I; Villegas N; de Herreros AG; Aloy P

Nature Communications

(1 )

3932 -

(2021)

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Rol Á; Todorovski T; Martin-Malpartida P; Escolà A; Gonzalez-Rey E; Aragón E; Verdaguer X; Vallès-Miret M; Farrera-Sinfreu J; Puig E; Fernández-Carneado J; Ponsati B; Delgado M; Riera A; Macias MJ

Nature Communications

(1 )

1869 -

(2021)

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

Pekmezovic M; Hovhannisyan H; Gresnigt MS; Iracane E; Oliveira-Pacheco J; Siscar-Lewin S; Seemann E; Qualmann B; Kalkreuter T; Müller S; Kamradt T; Mogavero S; Brunke S; Butler G; Gabaldón T; Hube B

Nature Microbiology

(5 )

643 -

(2021)

Timing the origin of eukaryotic cellular complexity with ancient duplications

Vosseberg J; van Hooff JJE; Marcet-Houben M; van Vlimmeren A; van Wijk LM; Gabaldón T; Snel B

Nature Ecology & Evolution

(1 )

92 -

100

(2021)

Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer

Martinez-Jimenez, F; Muinos, F; Lopez-Arribillaga, E; Lopez-Bigas, N; Gonzalez-Perez, A

Nature Cancer

(1 )

122 -

(2020)

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase

Zimmermann F; Serna M; Ezquerra A; Fernandez-Leiro R; Llorca O; Luders J

Science Advances

(51 )

eabe0894 -

(2020)

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Lynch CJ; Bernad R; Martínez-Val A; Shahbazi MN; Nóbrega-Pereira S; Calvo I; Blanco-Aparicio C; Tarantino C; Garreta E; Richart-Ginés L; Alcazar N; Graña-Castro O; Gómez-Lopez G; Aksoy I; Muñoz-Martín M; Martinez S; Ortega S; Prieto S; Simboeck E; Camasses A; Stephan-Otto Attolini C; Fernandez AF; Sierra MI; Fraga MF; Pastor J; Fisher D; Montserrat N; Savatier P; Muñoz J; Zernicka-Goetz M; Serrano M

Nature Cell Biology

(10 )

1223 -

(2020)

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Pittis AA; Goh V; Cebrian-Serrano A; Wettmarshausen J; Perocchi F; Gabaldón T

Nature Communications

(1 )

4031 -

(2020)

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Mas-Ponte D; Supek F

Nature Genetics

(9 )

958 -

(2020)

Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P

Nature Biotechnology

(9 )

1087 -

(2020)

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Morral C; Stanisavljevic J; Hernando-Momblona X; Mereu E; Álvarez-Varela A; Cortina C; Stork D; Slebe F; Turon G; Whissell G; Sevillano M; Merlos-Suárez A; Casanova-Martí À; Moutinho C; Lowe SW; Dow LE; Villanueva A; Sancho E; Heyn H; Batlle E

Cell Stem Cell

(6 )

845 -

(2020)

The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer

Pascual, Rosa; Martin, Judit; Salvador, Fernando; Reina, Oscar; Chanes, Veronica; Millanes-Romero, Alba; Suner, Clara; Fernandez-Miranda, Gonzalo; Bartomeu, Anna; Huang, Yi-Shuian; Gomis, Roger R; Mendez, Raul

Science Advances

(20 )

eaax3868 -

(2020)

Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols

Cabré A; Rafael S; Sciortino G; Ujaque G; Verdaguer X; Lledós A; Riera A

Angewandte Chemie (International Ed. Print)

(19 )

7521 -

7527

(2020)

Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers

Barrio L; Milán M

Developmental Cell

(5 )

659 -

(2020)

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

Isabel Hernandez-Alvarez, Maria; Sebastian, David; Vives, Sara; Ivanova, Saska; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sonia R.; Hernandez, Vanessa; Vasconcelos, Nuno; Peddinti, Gopal; Adrover, Anna; Jove, Mariona; Pamplona, Reinald; Gordaliza-Alaguero, Isabel; Calvo, Enrique; Cabre, Noemi; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Rodrigues, Cecilia M. P.; Orozco, Modesto; Joven, Jorge; Canto, Carles; Palacin, Manuel; Fernandez-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio;

Cell

177

(4 )

881 -

(2019)

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

Eftekharzadeh B; Banduseela V; Chiesa G; Martínez-Cristóbal P; Rauch J; Nath S; Schwarz D; Shao H; Marin-Argany M; Di Sanza C; Giorgetti E; Yu Z; Pieratelli R; Felli I; Brun-Heath I; García J; Nebreda Á; Gestwicki J; Lieberman A; Salvatella X

Nature Communications

(1 )

3562 -

(2019)

Evolutionary and functional patterns of shared gene neighbourhood in fungi

Marcet-Houben M; Gabaldón T

Nature Microbiology

(12 )

2383 -

2392

(2019)

The mutational footprints of cancer therapies

Pich O; Muiños F; Lolkema M; Steeghs N; Gonzalez-Perez A; Lopez-Bigas N

Nature Genetics

(12 )

1732 -

(2019)

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Lindeboom RGH; Vermeulen M; Lehner B; Supek F

Nature Genetics

(11 )

1645 -

(2019)

Atomic structure of the Epstein-Barr virus portal

Machón C; Fàbrega-Ferrer M; Zhou D; Cuervo A; Carrascosa J; Stuart D; Coll M

Nature Communications

(1 )

3891 -

(2019)

Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism

Cuervo A; Fàbrega-Ferrer M; Machón C; Conesa J; Fernández F; Pérez-Luque R; Pérez-Ruiz M; Pous J; Vega M; Carrascosa J; Coll M

Nature Communications

(1 )

3746 -

(2019)

An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases

Aranda J; Terrazas M; Gómez H; Villegas N; Orozco M

Nature Catalysis

(6 )

544 -

552

(2019)

The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry

Terrazas M; Genna V; Portella G; Villegas N; Sánchez D; Arnan C; Pulido-Quetglas C; Johnson R; Guigó R; Brun-Heath I; Aviñó A; Eritja R; Orozco M

Chem

(6 )

1619 -

1631

(2019)

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Escobedo A; Topal B; Kunze M; Aranda J; Chiesa G; Mungianu D; Bernardo-Seisdedos G; Eftekharzadeh B; Gairí M; Pierattelli R; Felli I; Diercks T; Millet O; García J; Orozco M; Crehuet R; Lindorff-Larsen K; Salvatella X

Nature Communications

(1 )

2034 -

(2019)

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

Errasti-Murugarren E; Fort J; Bartoccioni P; Díaz L; Pardon E; Carpena X; Espino-Guarch M; Zorzano A; Ziegler C; Steyaert J; Fernández-Recio J; Fita I; Palacín M

Nature Communications

(1 )

1807 -

(2019)

Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit

Picchioni D; Antolin-Fontes A; Camacho N; Schmitz C; Pons-Pons A; Rodríguez-Escribà M; Machallekidou A; Güler MN; Siatra P; Carretero-Junquera M; Serrano A; Hovde SL; Knobel PA; Novoa EM; Solà-Vilarrubias M; Kaguni LS; Stracker TH; Ribas de Pouplana L

Cell Reports

(1 )

40 -

(2019)

An In-Depth Look at DNA Crystals through the Prism of Molecular Dynamics Simulations

Kuzmanic A; Dans P; Orozco M

Chem

(3 )

649 -

663

(2019)

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

Benhra N; Barrio L; Muzzopappa M; Milán M

Developmental Cell

(2 )

161 -

(2018)

Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes

Pich O; Muiños F; Sabarinathan R; Reyes-Salazar I; Gonzalez-Perez A; Lopez-Bigas N

Cell

175

(4 )

1074 -

(2018)

TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β

Romero M; Sabaté-Pérez A; Francis VA; Castrillón-Rodriguez I; Díaz-Ramos Á; Sánchez-Feutrie M; Durán X; Palacín M; Moreno-Navarrete JM; Gustafson B; Hammarstedt A; Fernández-Real JM; Vendrell J; Smith U; Zorzano A

Nature Cell Biology

(4 )

443 -

(2018)

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Duch A; Canal B; Barroso S; García-Rubio M; Seisenbacher G; Aguilera A; De Nadal E; Posas F

Nature Communications

(1 )

379 -

(2018)

A versatile drug delivery system targeting senescent cells

Muñoz-Espín D; Rovira M; Galiana I; Giménez C; Lozano-Torres B; Paez-Ribes M; Llanos S; Chaib S; Muñoz-Martín M; Ucero AC; Garaulet G; Mulero F; Dann SG; VanArsdale T; Shields DJ; Bernardos A; Murguía JR; Martínez-Máñez R; Serrano M

Embo Molecular Medicine

(9 )

e9355 -

(2018)

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.

Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS, Batlle E

Nature

554

(7693 )

538 -

(2018)

NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

Freixo, Francisco; Delgado, Paula Martinez; Manso, Yasmina; Sanchez-Huertas, Carlos; Lacasa, Cristina; Soriano, Eduardo; Roig, Joan; Lueders, Jens

Nature Communications

(1 )

2330 -

(2018)

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

Cánovas B; Igea A; Sartori A; Gomis R; Paull T; Isoda M; Pérez-Montoyo H; Serra V; González-Suárez E; Stracker T; Nebreda A

Cancer Cell

(6 )

1094 -

(2018)

EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation

Silva J; Aivio S; Knobel PA; Bailey LJ; Casali A; Vinaixa M; Garcia-Cao I; Coyaud É; Jourdain AA; Pérez-Ferreros P; Rojas AM; Antolin-Fontes A; Samino-Gené S; Raught B; González-Reyes A; Ribas De Pouplana L; Doherty AJ; Yanes O; Stracker TH

Nature Cell Biology

(2 )

162 -

174

(2018)

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+breast cancer

Gawrzak S; Rinaldi L; Gregorio S; Arenas EJ; Salvador F; Urosevic J; Figueras-Puig C; Rojo F; Del Barco Barrantes I; Cejalvo JM; Palafox M; Guiu M; Berenguer-Llergo A; Symeonidi A; Bellmunt A; Kalafatovic D; Arnal-Estapé A; Fernández E; Müllauer B; Groeneveld R; Slobodnyuk K; Stephan-Otto Attolini C; Saura C; Arribas J; Cortes J; Rovira A; Muñoz M; Lluch A; Serra V; Albanell J; Prat A; Nebreda AR; Benitah SA; Gomis RR

Nature Cell Biology

(2 )

211 -

(2018)

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González JL, Picó S Hernández IH, Díaz-Hernández JI, Belloc E, Rodolosse A, Parikshak NN, Peñagarikano O, Fernández-Chacón R, Irimia M, Navarro P, Geschwind DH, Méndez R*, Lucas JJ*. (* co-corresponding authors).

Nature

560

(7719 )

441 -

(2018)

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress

Solanas G; Peixoto FO; Perdiguero E; Jardí M; Ruiz-Bonilla V; Datta D; Symeonidi A; Castellanos A; Welz PS; Caballero JM; Sassone-Corsi P; Muñoz-Cánoves P; Benitah SA

Cell

170

(4 )

678 -

(2017)

Reduced mutation rate in exons due to differential mismatch repair

Frigola J; Sabarinathan R; Mularoni L; Muinõs F; Gonzalez-Perez A; López-Bigas N

Nature Genetics

(12 )

1684 -

(2017)

Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial