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Research

At the forefront of biomedicine

Research publications

Origin of fungal hybrids with pathogenic potential from warm seawater environments
del Olmo, V; Mixao, V; Fotedar, R; Saus, E; Al Malki, A; Ksiezopolska, E; Nunez-Rodriguez, JC; Boekhout, T; Gabaldón, T
Nature Communications
14
1
6919 -
2023
Rational optimization of a transcription factor activation domain inhibitor
Basu, S; Martínez-Cristóbal, P; Frigolé-Vivas, M; Pesarrodona, M; Lewis, M; Szulc, E; Bañuelos, CA; Sánchez-Zarzalejo, C; Bielskute, S; Zhu, JQ; Pombo-García, K; Garcia-Cabau, C; Zodi, L; Dockx, H; Smak, J; Kaur, H; Batlle, C; Mateos, B; Biesaga, M; Escobedo, A; Bardia, L; Verdaguer, X; Ruffoni, A; Mawji, NR; Wang, J; Obst, JK; Tam, T;...
Nature Structural & Molecular Biology
30
1958 -
1969
2023
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
Kovatcheva, M; Melendez, E; Chondronasiou, D; Pietrocola, F; Bernad, R; Caballe, A; Junza, A; Capellades, J; Holguín-Horcajo, A; Prats, N; Durand, S; Rovira, M; Yanes, O; Attolini, CSO; Kroemer, G; Serrano, M
Nature Metabolism
5
11
1911 -
1930
2023
Roastgsa: a comparison of rotation-based scores for gene set enrichment analysis
Caballé-Mestres, A; Berenguer-Llergo, A; Attolini, CSO
Bmc Bioinformatics
24
1
408 -
2023
A concise guide to choosing suitable gene expression systems for recombinant protein production
Schütz, A; Bernhard, F; Berrow, N; Buyel, JF; Ferreira-da-Silva, F; Haustraete, J; van den Heuvel, J; Hoffmann, JE; de Marco, A; Peleg, Y; Suppmann, S; Unger, T; Vanhoucke, M; Witt, S; Remans, K
Star Protocols
4
4
102572 -
2023
A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing
Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M
Nature Cell Biology
25
11
1590 -
1599
2023
Chromosomal instability-induced cell invasion through caspase-driven DNA damage
Barrio, L; Gaspar, AE; Muzzopappa, M; Ghosh, K; Romao, D; Clemente-Ruiz, M; Milan, M
Current Biology
33
20
S0960 -
4
2023
Expansion microscopy of the chick embryo neural tube to overcome molecular crowding at the centrosomes-cilia
Wilmerding, A; Espana-Bonilla, P; Giakoumakis, NN; Saade, M
Star Protocols
4
1
101997 -
2023
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy
Redondo-Munoz, M; Rodriguez-Baena, FJ; Aldaz, P; Caballe-Mestres, A; Moncho-Amor, V; Otaegi-Ugartemendia, M; Carrasco-Garcia, E; Olias-Arjona, A; Lasheras-Otero, I; Santamaria, E; Bocanegra, A; Chocarro, L; Grier, A; Dzieciatkowska, MM; Bigas, C; Martin, J; Urdiroz-Urricelqui, U; Marzo, F; Santamaria, E; Kochan, G; Escors, D; Larrayoz, IM; Heyn,...
Nature Metabolism
5
9
1544 -
2023
scKINETICS: inference of regulatory velocity with single-cell transcriptomics data
Burdziak, C; Zhao, CJ; Haviv, D; Alonso-Curbelo, D; Lowe, SW; Pe'er, D
Bioinformatics
39
39 Suppl 1
i394 -
i403
2023
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
Naón, D; Hernández-Alvarez, MI; Shinjo, S; Wieczor, M; Ivanova, S; Martins de Brito, O; Quintana, A; Hidalgo, J; Palacín, M; Aparicio, P; Castellanos, J; Lores, L; Sebastián, D; Fernández-Veledo, S; Vendrell, J; Joven, J; Orozco, M; Zorzano, A; Scorrano, L
Science
380
6651
eadh9351 -
eadh9351
2023
Targeting lymphoid-derived IL-17 signaling to delay skin aging
Solá, P; Mereu, E; Bonjoch, J; Casado-Peláez, M; Prats, N; Aguilera, M; Reina, O; Blanco, E; Esteller, M; Di Croce, L; Heyn, H; Solanas, G; Benitah, SA
Nature Aging
3
6
688 -
2023
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR
Nature Communications
14
1
3318 -
2023
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Genna, V; Iglesias-Fernández, J; Reyes-Fraile, L; Villegas, N; Guckian, K; Seth, P; Wan, B; Cabrero, C; Terrazas, M; Brun-Heath, I; González, C; Sciabola, S; Villalobos, A; Orozco, M
Nucleic Acids Research
51
10
4713 -
4725
2023
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
Burdziak, C; Alonso-Curbelo, D; Walle, T; Reyes, J; Barriga, F; Haviv, D; Xie, YB; Zhao, Z; Zhao, CJ; Chen, HA; Chaudhary, O; Masilionis, I; Choo, ZN; Gao, V; Luan, W; Wuest, A; Ho, YJ; Wei, YH; Quail, DF; Koche, R; Mazutis, L; Chaligné, R; Nawy, T; Lowe, SW; Pe'er, D
Science
380
6645
597 -
2023
Biophysical and Computational Approaches to Study Ternary Complexes: A 'Cooperative Relationship' to Rationalize Targeted Protein Degradation
Ward, JA; Perez-Lopez, C; Mayor-Ruiz, C
Chembiochem
24
10
e202300163 -
2023
Time-resolved transcriptomic profiling of the developing rabbit's lungs: impact of premature birth and implications for modelling bronchopulmonary dysplasia
Storti, M; Faietti, ML; Murgia, X; Catozzi, C; Minato, I; Tatoni, D; Cantarella, S; Ravanetti, F; Ragionieri, L; Ciccimarra, R; Zoboli, M; Vilanova, M; Sánchez-Jiménez, E; Gay, M; Vilaseca, M; Villetti, G; Pioselli, B; Salomone, F; Ottonello, S; Montanini, B; Ricci, F
Respiratory Research
24
1
80 -
2023
Correlated motions in DNA: beyond base-pair step models of DNA flexibility
López-Güell, K; Battistini, F; Orozco, M
Nucleic Acids Research
51
6
2633 -
2640
2023
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress
Fernández-Alfara, M; Sibilio, A; Martin, J; Uxó, ET; Malumbres, M; Alcalde, V; Chanes, V; Cañellas-Socias, A; Palomo-Ponce, S; Batlle, E; Méndez, R
Embo Journal
42
9
e111494 -
2023
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
Maus, M; López-Polo, V; Mateo, L; Lafarga, M; Aguilera, M; De Lama, E; Meyer, K; Sola, A; Lopez-Martinez, C; López-Alonso, I; Guasch-Piqueras, M; Hernandez-Gonzalez, F; Chaib, S; Rovira, M; Sanchez, M; Faner, R; Agusti, A; Diéguez-Hurtado, R; Ortega, S; Manonelles, A; Engelhardt, S; Monteiro, F; Attolini, CSO; Prats, N; Albaiceta, G; Cruzado,...
Nature Metabolism
5
2111 -
2130
2023
Characterization of p38α signaling networks in cancer cells using quantitative proteomics and phosphoproteomics
Dan, YZ; Radic, N; Gay, M; Fernández-Torras, A; Arauz, G; Vilaseca, M; Aloy, P; Canos, B; Nebreda, AR
Molecular & Cellular Proteomics
22
4
100527 -
2023
The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
Gonzalez, L; Domingo-Muelas, A; Duart-Abadia, P; Nuñez, M; Mikolcevic, P; Llonch, E; Cubillos-Rojas, M; Cánovas, B; Forrow, SMA; Morante-Redolat, JM; Fariñas, I; Nebreda, AR
Iscience
26
3
106202 -
2023
Transient and DNA-free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis
Navaridas, R; Vidal-Sabanés, M; Ruiz-Mitjana, A; Perramon-Güell, A; Megino-Luque, C; Llobet-Navas, D; Matias-Guiu, X; Egea, J; Encinas, M; Bardia, L; Colombelli, J; Dolcet, X
Cancer Communications
43
5
620 -
624
2023
Copy number footprints of platinum-based anticancer therapies
Gonzalez, S; Lopez-Bigas, N; Gonzalez-Perez, A
Plos Genetics
19
2
e1010634 -
2023
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
Mensah, MA; Niskanen, H; Magalhaes, AP; Basu, S; Kircher, M; Sczakiel, HL; Reiter, AMV; Elsner, J; Meinecke, P; Biskup, S; Chung, BHY; Dombrowsky, G; Eckmann-Scholz, C; Hitz, MP; Hoischen, A; Holterhus, PM; Hülsemann, W; Kahrizi, K; Kalscheuer, VM; Kan, A; Krumbiegel, M; Kurth, I; Leubner, J; Longardt, AC; Moritz, JD; Najmabadi, H; Skipalova, K;...
Nature
614
7948
564 -
2023
pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs
Serrano-Chacon, I; Mir, B; Cupellini, L; Colizzi, F; Orozco, M; Escaja, N; Gonzalez, C
Journal Of The American Chemical Society
145
6
3696 -
3705
2023
Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG
Ali, A; Vineethakumari, C; Lacasa, C; Lüders, J
Nature Communications
14
1
289 -
2023
Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein
Machón, C; Ruiz-Masó, JA; Amodio, J; Boer, DR; Bordanaba-Ruiseco, L; Bury, K; Konieczny, I; del Solar, G; Coll, M
Nucleic Acids Research
51
3
1458 -
1472
2023
Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
Irazoki, A; Gordaliza-Alaguero, I; Frank, E; Giakoumakis, NN; Seco, J; Palacín, M; Guma, A; Sylow, L; Sebastián, D; Zorzano, A
Nature Communications
14
1
108 -
2023
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Wculek SK#, Heras-Murillo I, Mastrangelo A, Mañanes D, Galán M, Miguel V, Curtabbi A, Barbas, C, Chandel NS, Enríquez JA, Lamas S, Sancho D#
(#) Corresponding author
Immunity
(56:1-15)
2023
Local IL-17 orchestrates skin aging
Solá, Paloma; Mereu, Elisabetta; Bonjoch, Júlia; Casado, Marta; Reina, Oscar; Blanco, Enrique; Esteller, Manel; DiCroce, Luciano; Heyn, Holger; Solanas, Guiomar; Benitah, Salvador Aznar
Biorxiv : The Preprint Server For Biology
2022
Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans.
Carreté L; Ksiezopolska E; Pegueroles C; Gómez-Molero E; Saus E; Iraola-Guzmán S; Loska D; Bader O; Fairhead C; Gabaldón T
Current Biology
32
14
3219 -
3219
2022
Molecular glue degraders: From serendipity to hunting and design
Nieto-Barrado L; Domostegui A; Mayor-Ruiz C
In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.
177 -
204
2022
Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
Aranda, J; Wieczor, M; Terrazas, M; Brun-Heath, I; Orozco, M
Chem Catalysis
2
5
1084 -
1099
2022
Implementing re-configurable biological computation with distributed multicellular consortia
Canadell, D; Ortiz-Vaquerizas, N; Mogas-Diez, S; de Nadal, E; Macia, J; Posas, F
Nucleic Acids Research
50
21
12578 -
12595
2022
Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1
Pluta, R; Aragon, E; Prescott, NA; Ruiz, L; Mees, RA; Baginski, B; Flood, JR; Martin-Malpartida, P; Massague, J; David, Y; Macias, MJ
Nature Communications
13
1
7279 -
2022
A glutamine-based single α-helix scaffold to target globular proteins
Escobedo, A; Piccirillo, J; Aranda, J; Diercks, T; Mateos, B; Garcia-Cabau, C; Sánchez-Navarro, M; Topal, B; Biesaga, M; Staby, L; Kragelund, BB; García, J; Millet, O; Orozco, M; Coles, M; Crehuet, R; Salvatella, X
Nature Communications
13
1
7073 -
2022
Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis
Molnar, C; Reina, J; Herrero, A; Heinen, JP; Méndiz, V; Bonnal, S; Irimia, M; Sánchez-Jiménez, M; Sánchez-Molina, S; Mora, J; Gonzalez, C
Pnas Nexus
1
4
pgac222 -
2022
Illuminati: a form of gene expression plasticity in Drosophila neural stem cells
Goupil, A; Heinen, JP; Salame, R; Rossi, F; Reina, J; Pennetier, C; Simon, A; Skorski, P; Louzao, A; Bardin, AJ; Basto, R; Gonzalez, C
Development
149
22
200808 -
2022
Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Cañellas-Socias, A; Cortina, C; Hernando-Momblona, X; Palomo-Ponce, S; Mulholland, EJ; Turon, G; Mateo, L; Conti, S; Roman, O; Sevillano, M; Slebe, F; Stork, D; Caballé-Mestres, A; Berenguer-Llergo, A; Alvarez-Varela, A; Fenderico, N; Novellasdemunt, L; Jiménez-Gracia, L; Sipka, T; Bardia, L; Lorden, P; Colombelli, J; Heyn, H; Trepat, X;...
Nature
611
7936
603 -
613
2022
Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states
Zhu, JQ; Salvatella, X; Robustelli, P
Nature Communications
13
1
6390 -
2022
Deciphering the roadmap of in vivo reprogramming toward pluripotency
Chondronasiou, D; de Villarreal, JM; Melendez, E; Lynch, CJ; del Pozo, N; Kovatcheva, M; Aguilera, M; Prats, N; Real, FX; Serrano, M
Stem Cell Reports
17
11
2501 -
2517
2022
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation
Gonzalez-Arzola, K; Diaz-Quintana, A; Bernardo-Garcia, N; Martinez-Fabregas, J; Rivero-Rodriguez, F; Casado-Combreras, MA; Elena-Real, CA; Velazquez-Cruz, A; Gil-Caballero, S; Velazquez-Campoy, A; Szulc, E; Gavilan, MP; Ayala, I; Arranz, R; Rios, RM; Salvatella, X; Valpuesta, JM; Hermoso, JA; De la Rosa, MA; Diaz-Moreno, I
Nature Structural & Molecular Biology
29
10
1024 -
2022
The role of lipids in cancer progression and metastasis
Martin-Perez, M; Urdiroz-Urricelqui, U; Bigas, C; Benitah, SA
Cell Metabolism
34
11
1675 -
1699
2022
Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
Ulsamer, A; Martínez-Limón, A; Bader, S; Rodríguez-Acebes, S; Freire, R; Méndez, J; de Nadal, E; Posas, F
Cell Reports
40
12
111375 -
2022
Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the Bioteque
Fernández-Torras, A; Duran-Frigola, M; Bertoni, M; Locatelli, M; Aloy, P
Nature Communications
13
1
5304 -
2022
Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation
Duran-Arqué, B; Cañete, M; Castellazzi, CL; Bartomeu, A; Ferrer-Caelles, A; Reina, O; Caballé, A; Gay, M; Arauz-Garofalo, G; Belloc, E; Mendez, R
Genome Biology
23
1
192 -
2022
Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors
Rivas, EI; Linares, J; Zwick, M; Gómez-Llonin, A; Guiu, M; Labernadie, A; Badia-Ramentol, J; Lladó, A; Bardia, L; Pérez-Núñez, I; Martínez-Ciarpaglini, C; Tarazona, N; Sallent-Aragay, A; Garrido, M; Celià-Terrassa, T; Burgués, O; Gomis, RR; Albanell, J; Calon, A
Nature Communications
13
1
5310 -
2022