Building Basement Membranes in Drosophila: Secretion, Assembly and Role in Tissue Growth
Speaker: Jose C. Pastor-Pareja, PhD Principal Investigator School of Life sciences, Tsinghua University, Beijing, China
Organizer: IRB Barcelona
Date: Wednesday, 19 July 2017, 15.00h
Place: Aula Fèlix Serratosa, Parc Científic de Barcelona, Spain
Host: Marco Milán, IRB Barcelona
Basement membranes (BMs) are polymers of matrix proteins underlying epithelia and surrounding organs in all animals. BMs and Collagen IV, their main component, are actually the key evolutionary innovations allowing the existence of tissues and the evolution of complex body plans in the Metazoa. In my laboratory, we are trying to understand the biology of tissues and BMs using the fruit fly Drosophila melanogaster as a model organism, mostly through genetics and cell biology approaches. During my talk, I will present our findings regarding the secretion of Collagen IV, the hierarchy of assembly of BM components and the developmental roles of BMs in mechanically shaping tissues and regulation of tissue growth. In addition, I will discuss recent data from my laboratory showing that Collagen IV can mediate intercellular adhesion through a novel form of matrix organization that we call CIVICs (Collagen IV Intercellular Concentrations).
Cell and Developmental Biology Programme Seminar