Presentation
Organizer: IRB BioMed Seminars
Date / Time: Friday, October 23 at 12:00
Place: Auditorium PCB
Speaker: Professor Elvan Böke PhD. Group Leader, Oocyte Biology & Cellular Dormancy, Centre for Genomic Regulation (CRG)
Host: Prof. Salvador Aznar. Group Leader, Stem Cells and Cancer Lab - Chair of the Aging and Metabolism Programme. IRB Barcelona
Oocytes are female germ cells that become eggs. They have the remarkable ability to survive for long periods of time, up to 50 years in humans, while retaining the potential to give rise to a new organism. We know surprisingly little about the molecular mechanisms that protect oocytes from cellular ageing, and why these mechanisms eventually fail with advanced age.
In my talk, I will discuss our recent discoveries that address two major challenges oocytes face during their long lifespan. First, I will show how oocytes limit damage caused by Reactive Oxygen Species (ROS) by rewiring their metabolism. Second, I will describe how mouse and human oocytes manage protein aggregation and, more broadly, preserve protein homeostasis. Together, these discoveries highlight the remarkable adaptations of oocyte metabolism and proteostasis that support the long oocyte lifespan.
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar
The weekly seminars at IRB Barcelona are scientific events primarily addressed to the Institute’s research community and professionals in the biomedical field. Attendance is intended exclusively for individuals with a genuine and justified scientific interest in the seminar content. Registration should not be used to request supporting documents for visa or immigration purposes. For participants residing outside Spain, in-person attendance requires a formal invitation issued by an IRB Barcelona research group or department. Without such an invitation, access to the institute cannot be guaranteed. IRB Barcelona reserves the right to review and verify all seminar registrations.