Presentation
Organizer: IRB BioMed Seminars
Date / Time: Thursday, July 9 at 12:00
Place: Félix Serratosa
Speaker: Professor Leila Perié PhD. Ikerbasque Research Professor, Group Leader of the Quantitative immuno-hematology Group, Biogipuzkoa
Host: Prof. Alejo Rodríguez Fraticelli. Junior Group Leader Quantitative Stem Cell Dynamics Lab, Aging and Metabolism Programme
Cell division drives multicellular growth, and its dysregulation can cause disease. Without cell death, approximately 44 divisions are needed to produce all 1013 cells in the human body, but current methods are limited to count 10 cell divisions in vivo across diverse mammalian cell types. We developped the DivisionCounter, a method to count cell division in vivo over large division ranges (~70 divisions) using an easy fluorescence readout. We demonstrate that the DivisionCounter accurately measures the average cell division count of cells both in vitro and in vivo. Its use revealed that leukemia tumour division rates are independent of the organ’s specific microenvironment and CAR-T cell treatment, providing an estimate of tumour death rates in vivo. The DivisionCounter method holds unique potential for quantifying contributions of cell division, death, and migration to the growth of healthy and pathological mammalian tissues.
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