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The Hippo pathway, from discovery in Drosophila to cancer drug target

Presentation

Organizer: IRB BioMed Seminars

Date / Time: ​Tuesday Sep 23 at 12:00

Place: Fèlix Serratosa

Speaker: Professor (Research), Anatomy & Developmental Biology, Monash Biomedicine Discovery Institute;  Group Leader and Programme Head, Peter MacCallum Cancer Centre, Victoria, Australia. 

Host: Marco Milán, Ph.D. - Programme Chair - Group Leader, IRB Barcelona - Mechanisms of Disease Programme.

 

 

Brief CV – Professor Kieran F. Harvey, PhD, B Health Sci (hons), B Sc.

Professor Kieran Harvey holds dual appointments at the Peter MacCallum Cancer Centre (Peter Mac) and Monash University, in Australia. At Peter Mac, he leads the Organogenesis and Cancer Program and at Monash he runs a laboratory in the Department of Anatomy and Developmental Biology.


Kieran’s team studies organ size control during development, using Drosophila, and how signalling pathways that control organ size are deregulated in human cancer. In particular his group focuses on the Hippo pathway, which he helped to discover in Prof. Iswar Hariharan’s laboratory in the early 2000’s. More recently, his lab has used advanced microscopy approaches to investigate how the Hippo pathway regulates transcription, and the mechanism of action of the first Hippo pathway targeted therapies (e.g. Kroeger et al, Dev Cell, 2024; Manning et al, Dev Cell 2024; Kroeger et al, bioRxiv, 2025).


Kieran performed Doctoral studies with Prof. Sharad Kumar in Australia (University of Adelaide), and postdoctoral studies with Prof. Iswar Hariharan in the USA (Massachusetts General Hospital/Harvard Medical Center and University of California, Berkeley). In 2006, Kieran established an independent laboratory at Peter Mac. Kieran was awarded the Gottschalk Medal by the Australian Academy of Science in 2014, for outstanding research in the medical sciences, and he served as President of the Australia and New Zealand Society for Cell and Developmental Biology from 2021-23.

 

 

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