Speaker: Prof. Rubén Nogueiras Pozo
Group Leader | Associate Professor, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela (USC), Spain
Presentation
Host: Metabolism in Physiology (MIP) - Interest Group
Node: Preclinical Models of Disease / Cell Pathophysiology
Date: Wednesday 17 December 2025, 12h
Place: Auditorium Room
Liver fibrosis, a hallmark of chronic liver disease, is primarily driven by the activation of hepatic stellate cells (HSCs), which undergo profound phenotypic and functional changes. Emerging evidence indicates that metabolic reprogramming in HSCs is a critical regulator of their activation and fibrogenic potential. Activated HSCs shift towards glycolysis, enhanced glutaminolysis, and altered lipid metabolism occurs to meet the increased energetic demands of fibrogenesis. These metabolic adaptations not only support HSC proliferation and extracellular matrix production but also modulate their response to inflammatory and profibrotic signals. Understanding the mechanisms underlying HSC metabolic shifts provides novel insights into liver fibrosis progression and identifies potential therapeutic targets aimed at restoring metabolic balance to halt or reverse fibrotic remodeling.
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