Mutant Wnt pathway tumour suppressors in cancer: beyond loss-of-function
Speaker: Madelon Maurice, PhD Center for Molecular Medicine, University Medical Center Utrecht, The Netherlands
Organizer: IRB Barcelona
Date: Thursday, June 29th 12.00h
Place: Aula Fèlix Serratosa, Parc Científic de Barcelona, Spain
Host: Dr. Daniele Tauriello, IRB Barcelona
WNT proteins comprise a large family of conserved, secreted glycolipoproteins that control the maintenance and proliferative activity of stem cell reservoirs during tissue self-renewal and regeneration. Inappropriate WNT signalling activity is strongly linked to cancer development. Mutational inactivation of tumour suppressors due to loss-of-function (LOF) mutations is a well-known and common step in the initiation of tumour growth and progression. I will present several lines of evidence that alter this view for various mutant tumour suppressors, portraying them not as inert proteins, but rather as converted proteins that acquire novel and unique activities to drive uncontrolled proliferation. By obtaining a mechanistic understanding of how these mutations alter the structure and function of key Wnt pathway tumour suppressors we aim to provide novel clues on how to interfere with signalling aberrations in cancer cells.
Oncology Programme Seminar