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Understanding the role of solute carriers in health & disease


Organizer: IRB BioMed Seminars

Date: Friday 5 July 2024, 12:00h

Place: Fèlix Serratosa Hall, PCB

Speaker: Prof Simon Newstead - David Phillips Chair in Molecular Biophysics - University of Oxford  - Oxford | UK

Host: Manuel Palacín, PhD - Group Leader - Amino Acid Transporters and Disease -  Aging and Metabolism Programme - IRB Barcelona



Transporters belonging to the Solute Carrier (SLC) family are integral membrane proteins that play essential roles in human physiology. They predominantly function to regulate the transport of small molecules into and out of cells and regulate the availability of amino acids, ions, sugars, lipids and vitamins within the body. SLC transporters also function within intracellular signalling networks, particularly with respect to amino acid and nutrient sensing. Recently, the role of solute carriers in protein trafficking has revealed the close link between transport, cellular homeostasis and signalling in the cell. My talk will focus on recent work from my group that reveals new insights into clinically important solute carrier systems: how they function as drug transporters, the mechanisms used to regulate their function, their role in organelle homeostasis and how their function in the cell is likely far more widespread than previously thought

IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar