Skip to main content

Unraveling Myeloid Cell Diversity in Cancer

Presentation

Organizer: IRB BioMed Seminars

Date: Friday 20 December 2024, 12:00h

Place: Felix Serratosa Hall, PCB

Speaker: Leila Akkari, PhD - Group Leader - Macrophages in Cancer - The Netherlands Cancer Institute (NKI) - Amsterdam | Netherlands

Host: Stefanie Wculek, PhD - Junior Group Leader - Innate Immune Biology - Aging and Metabolism Programme - IRB Barcelona

 

Abstract

Tumors growing in metabolically-challenged environments are particularly reliant on cancer cells and immune cell metabolic cross-talk to satisfy their high metabolic needs. However, the intricacies of this metabolic interplay and the consequences on immune cell subsets diversity and function remain largely unexplored. We interrogated the heterogeneity of the tumor microenvironment using multi-omics analyses in preclinical brain and liver cancer mouse models and patient datasets and identified metabolically-rewired tumor-associated macrophage (TAMs), myeloid cells and regulatory T cell subpopulations fueling cancer progression and resistance to standard of care and immunotherapies. Our work reveals the dynamic evolution of specific immune cell compartment and how they support disease relapse, with potential for exploiting these vulnerabilities therapeutically.

 

 

In collaboration with:
Image
fundación bbva

IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar

Registration

Registration required only for attendees outside the PCB community at least 24hours before the seminar.

For security reasons you have to provide a valid DNI/ID/passport number in order to access the PCB Building.
Check if you are an IRB Alumni