Institutional news
9 Sep 2011

Iproteos has been a semi-finalist in the II Award for the Best Entrepreneurial Biotechnology Project, a technology transfer prize given by the Spanish Society of Biochemistry (Sociedad Española de Bioquímica (SEBBM)). The spin-off, which is promoted by IRB Barcelona –located at the Barcelona Science Park- and the University of Barcelona –through the Bosch y Gimpera Foundation, also at the Park – was founded in June with the mission to develop and commercialize a new generation of more efficient low cost drugs with fewer side effects.


Scientific news
<p>Structure of NCBD when it is not bound to any other protein</p>
8 Sep 2011

Proteins, the molecular machines that carry out the majority of the functions within a cell, are typically seen as possessing a specific three-dimensional structure. Cellular processes (e.g. reproduction) are activated or deactivated by a molecular choreography that involves the binding of one protein to another. Of late, it has been recognized that even a small protein (say, of size 50 residues) can binding to multiple partners – this results in an advantageous situation for the cell wherein depending on the identity of the partner a different functional response can be generated. In parallel, it has become increasingly evident that a single static structure is a poor representation...

Scientific news
<p>Individual intestinal stem cells generate spherical organoids when grown in lab-plates (upper pannel). Under the microscope (lower pannel), these organoids reveal to be composed mostly by undiferentiated and proliferative cells, the intestinal stem cells</p>
4 Sep 2011

Human colon stem cells have been identified and grown in a lab plate for the first time. This achievement, made by researchers in the Colorectal Cancer Lab at the Institute for Research in Biomedicine (IRB Barcelona) and published in Nature Medicine, is a crucial advance towards regenerative medicine.

Scientific news
<p>Interneuron obtained from an engineered mouse lacking the malin gene (in green) and showing the accumulation of Lafora bodies (in red).</p>
29 Aug 2011

Using a mouse model, researchers at IRB Barcelona have demonstrated a link between abnormal sugar accumulation and the neuronal degeneration characteristic of Lafora disease. The study may contribute to understanding the origin and progression of Lafora and other neurodegenerative pathologies.

Scientific news
<p>The localization of CenH3 protein in the centromere (upper panel) becomes inespecific along the chromosome (lower panel) when its regulated degradation is unpaired.</p>
25 Aug 2011

Researchers at IRB Barcelona discover a crucial mechanism controlling the segregation of genetic material from parent to daughter cells. A finely tuned process of degradation tightly regulates CenH3 protein levels to ensure the correct function of the cell division machinery in Drosophila.

Scientific news
<p>3D representation of the protein complex necessary for the activation of pho regulon genes in E. coli. The RNA polymerase protein (RNAP) binds to the transcriptional activator PhoB.</p>
9 Aug 2011

The use of crystallography allows us to 'see' the regulation of gene expression in bacteria.

Scientific news
<p>Healthy intestinal crypts (upper image) maintain different cell types in their compartments. Cells located at the bottom of the crypt (lower image) in which ADAM10 is blocked (lower image) migrate to the upper cell compartment (cells in dark brown)</p>
1 Aug 2011

Researchers at IRB Barcelona describe the molecular mechanisms that define distinct territories in the intestinal epithelium.

These molecular mechanisms could be highly relevant in the development of malignant tumors.

Scientific news
<p>The boundary between dorsal (D) and ventral (V) cell populations is smooth in wild type wing primordia (upper panel) and wiggly upon ectopic expression of bantam miRNA (bottom panel).</p>
28 Jul 2011

Two quests, one looking into adhesion molecules to gain insight into compartmentalization in the Drosophila wing and the other aiming to discover how the cytoskeleton contributes to the development of compartment boundaries are now linked by a single microRNA, bentam.

Scientific news
22 Jul 2011

These research results could revolutionize reproductive medicine and human stem cell studies.

Scientific news
<p>Functional myocardium (S) from a normal mouse embryo (left). The absence of p38&#945. and p38&#946. proteins produces myocardium lacking the heart septal (right).</p>
22 Jul 2011

The proteins p38α and p38β cooperate during embryo development. This finding suggests that they may also do so in other contexts such as cancer and cardiac diseases.