A team headed by Antonio Zorzano at IRB Barcelona has identified activators of the mitochondrial protein Mitofusin 2 for the treatment of type 2 diabetes.
The protein is a key regulator of many mitochondrial functions, as well as of the cell as a whole.
GenStorm (“An integrated approach to visualize and model the spatial conformation of genes at the nanoscale level”), led by Pablo Daniel Dans (IRB Barcelona) and Marie Victoire Neguembor (CRG) is one of this projects.
Published in Nature Cell Biology (NCB), the study shows that the EXD2 protein is critical for the mitochondria, the cell’s powerhouses, to produce energy.
This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair.
The results contribute to our basic understanding of mitochondria and suggest that EXD2 could be important for fertility and represent a potential target for cancer therapy.
The programme seeks to stir young people’s interest in science by allowing them to get involved in real projects.
"Crazy About Biomedicine" is part of an initiative run by the Fundación Catalunya - La Pedrera.
The Ferrer Research Foundation acknowledges the various perspectives of his research into cancer and aging.
Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.
The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility.
Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.
Xavier Salvatella, ICREA researcher at IRB Barcelona, proposes a new approach to combat prostate tumour cells that have become unresponsive to the treatments currently available.
The incidence of prostate cancer is increasing worldwide. In the US and Europe, it is one of the most common tumours and among the main causes of death by cancer.
The European Molecular Biology Lab (EMBL) in Barcelona and IRB Barcelona bring together leading scientists in the conference “Morphogenetic Engineering”, an event supported by the BBVA Foundation.
The merge of various disciplines of developmental biology is key to enhancing our knowledge of tissue development and repair, processes that find their most direct applications in regenerative medicine.
“One day we will be able to re-build damaged organs and keep the whole body fit and healthy. But right now we must strengthen our knowledge of how tissues are built and how they are maintained,” say James Sharpe, Head of EMBL Barcelona, and Marco Milán, coordinator of the Cell and Developmental Biology programme.
Specialists advance toward the “Google Earth” of the genome, which will allow them to see the detailed structure of DNA folded within the nucleus, from atomic resolution to the level of the entire molecule
3D genomics promises to reveal the hidden layer of gene regulation and allow researchers to uncover the causes of many diseases
20 world leaders in 3D genomics will meet today until Wednesday in Barcelona at the Barcelona BioMed Conference organized by IRB Barcelona and the BBVA Foundation.