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Centrosomes remember which way is up

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IRB Barcelona researchers Jens Januschke and Cayetano Gonzalez are the subject of the "In Focus" feature in the March 1 issue of the Journal of Cell Biology, published by the Rockefeller University Press.

In a research article published in the same issue, Gonzalez and Januschke show that brain stem cells called neuroblasts rely on the centrosome to store their orientation for division. A neuroblast normally divides so that the daughter cells emerge basally. But after the researchers depolymerized the neuroblast's microtubules, a daughter cell could emerge from other locations around the neuroblast.

About IRB Barcelona

The Institute for Research in Biomedicine (IRB Barcelona) pursues a society free of disease. To this end, it conducts multidisciplinary research of excellence to cure cancer and other diseases linked to ageing. It establishes technology transfer agreements with the pharmaceutical industry and major hospitals to bring research results closer to society, and organises a range of science outreach activities to engage the public in an open dialogue. IRB Barcelona is an international centre that hosts 400 researchers and more than 30 nationalities. Recognised as a Severo Ochoa Centre of Excellence since 2011, IRB Barcelona is a CERCA centre and member of the Barcelona Institute of Science and Technology (BIST).