Inbiomotion’s MAF Test® included in 2025 SEOM-GEICAM-SOLTI Clinical Practice Guidelines for Early-Stage Breast Cancer, further supporting its clinical utility

The IRB Barcelona spin-off Inbiomotion announced today that its MAF Test® has been included in the 2025 SEOM-GEICAM-SOLTI Clinical Practice Guidelines for Early-Stage Breast Cancer, a key consensus document guiding clinical decision-making in Spain and referenced internationally.

The guidelines, jointly developed by the Spanish Society of Medical Oncology (SEOM), the Spanish Breast Cancer Research Group (GEICAM) and the Spanish Collaborative Group for the Study, Treatment and Other Experimental Strategies in Solid Tumors (SOLTI), recognize the MAF Test® as a tool to help guide clinicians on early breast cancer patients.

This guideline inclusion is underpinned by multiple clinical analyses demonstrating that MAF status is associated with differential outcomes in patients treated with adjuvant bisphosphonates. Evidence cited in support of the recommendation shows that patients with MAF-negative tumors have shown improved invasive disease-free survival, disease-free survival and overall survival with bisphosphonate treatment. In contrast, MAF-positive tumors may be associated with an increased risk of extra skeletal recurrence. The MAF Test® may therefore support more refined patient selection by identifying those unlikely to benefit from adjuvant bisphosphonates.

“Guideline inclusion is a key inflection point for diagnostic innovation,” said Dr. Joël Jean-Mairet, PhD, Executive Chairman at Inbiomotion. “It reflects independent expert consensus around the clinical relevance of MAF status in early breast cancer and supports a clear goal: helping clinicians optimize adjuvant treatment decisions while reducing unnecessary therapy.”

Adjuvant bisphosphonates are broadly recommended for postmenopausal women and for patients undergoing ovarian suppression who are considered at higher risk of recurrence. Historically, however, the lack of predictive tools has limited clinicians’ ability to personalize bisphosphonate use. The MAF Test® addresses this gap by enabling more precise treatment decisions based on tumor biology.

“The inclusion of the MAF Test® in the SEOM-GEICAM-SOLTI Guidelines for Early Breast Cancer reflects the increasing integration of tumor biology into adjuvant treatment decision-making,” said Dr. Roger Gomis, Chief Scientific Officer at Inbiomotion, Group Leader at IRB Barcelona and ICREA Research Professor. “It provides clinicians an additional, evidence-based option to personalize therapy and to better identify patients for whom treatment may not be beneficial.”

The SEOM-GEICAM-SOLTI guidelines are widely adopted in clinical practice across Spain and are influential in shaping standards of care, reimbursement discussions and clinical adoption pathways. 
Inbiomotion believes this inclusion strengthens the positioning of the MAF Test® within precision oncology and supports the company’s long-term strategy.