Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.
A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.
The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.
The newspaper La Tribuna de Albacete has interviewed IRB Barcelona researcher Erika López Arribillaga about a grant awarded to her on 24 September by the Spanish Association Against Cancer (AECC). López Arribillaga’s project aims to unravel the long-term effects of some chemotherapy treatments on colorectal cancer patients.