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p53: Tumour suppressor protein determines organ size

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The online media Laboratory Journal echoes the latest work carried out by Marco Milán’s lab. Milán is the coordinator of the Cell and Developmental Biology Programme at IRB Barcelona. Published in PLoS Biology, the study reveals that the anti-tumour protein p53 regulates the proportionate growth of organs during embryonic development. “These experiments indicate that stressed cells send signals to the remaining tissues in order to reduce their growth in order to allow damaged tissue to repair itself and allow the organ to grow in a coordinated manner”, explains Milán.

About IRB Barcelona

The Institute for Research in Biomedicine (IRB Barcelona) pursues a society free of disease. To this end, it conducts multidisciplinary research of excellence to cure cancer and other diseases linked to ageing. It establishes technology transfer agreements with the pharmaceutical industry and major hospitals to bring research results closer to society, and organises a range of science outreach activities to engage the public in an open dialogue. IRB Barcelona is an international centre that hosts 400 researchers and more than 30 nationalities. Recognised as a Severo Ochoa Centre of Excellence since 2011, IRB Barcelona is a CERCA centre and member of the Barcelona Institute of Science and Technology (BIST).