The programme “El Balcó” broadcasted by the radio channel Cadena Ser has interviewed Manuel Serrano, ICREA researcher and head of the Cell Plasticity and Disease Lab at IRB Barcelona. The interview was about regenerative medicine, a kind of medicine that attempts to understand tissue regeneration mechanisms. “The regenerative process is well described and it is known what happens.
Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.
A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.
The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.