Medical Research has interviewed Alexandra Avgustinova, postdoctoral fellow at IRB Barcelona, about a study published as first author in the journal Nature Cell Biology. In the interview she explains that they have demonstrated that the common belief that chromatin opening is one of the determinants of a number of DNA mutations is incorrect. This discovery, says Avgustinova, is important for the fields of oncology and cancer genomics. “We were surprised to see that this observation was interpreted as a causal association, as it was, to a great extent, based on correlative studies without any experimental support. We decided to experimentally test for the first time whether the alteration of chromatin opening affects the mutation rate or the distribution of mutations within the tumours,” explains Avgustinova.
Link to Medical Research