Several media, including Quo Magazine, have echoed the research headed by Ferran Azorín, CSIC research professor and group leader of the Chromatin Structure and Function laboratory at IRB Barcelona. The study reveals why histone 1 is a major protection factor against genomic instability and a vital protein for the organism.
Published in Nature Communications, this work explains for the first time that the suppression of histone 1 causes cell damage and genomic instability (DNA damage).
Link to Quo
Selected media mentions
Link to SINC Agency
Link to Madridmasde
Catalunya Press, Revista Genética, among other national and international media, have published articles about a study co-led by Travis H. Stracker, head of the Genomic Instability and Cancer Lab, which has identified a key role for enzymes in DNA replication and sensitivity to chemotherapeutic drugs.
Link to Catalunya Press
Link to Revista Genética
Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.
Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.
Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials
IRB Barcelona receives today eight students that will participate through the workshop "Drosophila melanogaster: a model to study human disease".
