Zombie cells: responsible for damage in the organism
“Futuro a fondo” has published an article about the video "Meet Our Scientists", starring Manuel Serrano, a researcher at IRB Barcelona. In the video he talks about his research into how damaged tissues are repaired and therapies based on regenerative medicine.
Link to Futuro a fondo
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Researchers at IRB Barcelona discover a new mechanism in estrogen receptor-positive breast cancer cells.
The inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer.
Manuel Serrano, ICREA researcher at IRB Barcelona, participated in the programme Inmortals, broadcasted on TV3, in which he talked about aging. The slowing down of aging in mouse has been achieved. It is now only a question of time until the resources are available to reverse aging and increase lifespan in humans. In this regard, Serrano says, “I don’t know whether the limit will be 120 or 140 years, but I am sure lifespan will increase"
Link to TV3
Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.
A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.
The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.
