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Beta amyloid protein and AD are strongly linked but the role of this protein in this disease remains elusive. Hippocampus of transgenic mice overexpressing amyloid beta. In blue, neuronal nuclei. In green, beta amyloid plaques (E.Verdaguer/S.Brox)
Scientific - Published in PNAS
New strategy to obtain a specific type of amyloid-beta aggregate that may underlie neuronal death in Alzheimer’s disease
Depicted above, (+)-ryanodol is a derivate of a natural compound with intracellular calcium-regulating capacity
Scientific - Published in Science
Building molecular complexity from scratch
Eadweard Muybridge's pictures of a galloping horse enabled detailed analysis of animals and humans in motion. Today's protein research is faced with a similar situation when trying to understand how proteins move. (L. Orellana)
Scientific - Published in Nature Communications
A minimalist theory to predict protein movements
Shuttle peptides are molecules that have the capacity to transport drugs across the blood-brain barrier and thus treat diseases affecting the central nervous system
Scientific - Published in Chemical Society Reviews
Sights set on the next generation of shuttle peptides to target the brain
Structure of the Androgen Receptor. NTD: N-terminal domain; DBD: DNA binding domain; LBD: Ligand binding domain. Numbers indicate the first and last aminoacids of the protein, and the domain limits.
Scientific - Published in ACS Chemical Biology
Researchers discover the hidden potential of disordered proteins
Innovation
Deep sea pharmacy
Biomathematician Camille Stephan-Otto Attolini heads the Biostatistics and Bioinformatics Unit
Institutional
Stephan-Otto: “In the near future, there’s going to be one biostatistician in every biomedical laboratory”
Skin stem cells. In blue, a marker of the cell nucleus. In green, a marker for the Dnmt3a protein, which is critical to ensure that cells retain stem cell features (Lorenzo Rinaldi, IRB Barcelona)
Scientific - Published in Cell Stem Cell
Two proteins safeguard skin stem cells
Microscopy image of a culture mouse neuron showing the microtubule network in green and red depending on chemical modifications. The axon, in bright green, is the neuronal extension that has the greatest number of modified microtubules (Author: Carlos Sán
Scientific - Published in Nature Communications
Researchers discover the machinery that neurons use to form and maintain their neuronal extensions

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