Ekaitz Errasti

    Research Group: 
    Amino Acid Transporters and Disease
    Unit: 
    AGING & METABOLISM
    Position: 
    Research Associate
    Office: 
    EMPBA11A14
    Telephone: 
    +34 93 40 34701
    Email: 
    ekaitz.errasti@irbbarcelona.org

     

    View research group

    Selected group publications

    Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand
    Luis Martínez-Crespo, Jia Liang Sun-Wang, Andres Felipe Sierra, Gemma Aragay, Ekaitz Errasti-Murugarren, Paola Bartoccioni, Manuel Palacín, P.Ballester
    Chem , 6 (11), 3054-3070 (2020)
    Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7
    Bartoccioni P, Fort J, Zorzano A, Errasti-Murugarren E and Palacín M.
    J Gen Physiol, 151 (4), 505-517 (2019)
    L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
    Errasti-Murugarren E, Fort J, Bartoccioni P, Díaz L, Pardon E, Carpena X, Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernández-Recio J, Fita I and Palacín M.
    Nat Commun, 10 (1), 1807 (2019)
    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss
    Espino Guarch M, Font-Llitjós M, Murillo-Cuesta S, Errasti-Murugarren E, Celaya AM, Girotto G, Vuckovic D, Mezzavilla M, Vilches C, Bodoy S, Sahún I, González L, Prat E, Zorzano A, Dierssen M, Varela-Nieto I, Gasparini P, Palacín M and Nunes V.
    Elife, 7 (2018)
    Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability
    de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg MH, Palacín M and Féral CC.
    J Biol Chem, 291 (18), 9700-11 (2016)
    Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
    Sebastián D, Sorianello E, Segalés J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Muñoz JP, Sánchez-Feutrie M, Plana N, Hernández-Álvarez MI, Serrano AL, Palacín M and Zorzano A.
    Embo J, 35 (15), 1677-93 (2016)
    Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1
    Nagamori S, Wiriyasermkul P, Guarch ME, Okuyama H, Nakagomi S, Tadagaki K, Nishinaka Y, Bodoy S, Takafuji K, Okuda S, Kurokawa J, Ohgaki R, Nunes V, Palacín M and Kanai Y.
    P Natl Acad Sci Usa, 113 (3), 775-80 (2016)
    Digenic Inheritance in Cystinuria Mouse Model
    Espino M, Font-Llitjós M, Vilches C, Salido E, Prat E, López de Heredia M, Palacín M and Nunes V.
    PLoS One, 10 (9), e0137277 (2015)
    Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes
    Sala D, Ivanova S, Plana N, Ribas V, Duran J, Bach D, Turkseven S, Laville M, Vidal H, Karczewska-Kupczewska M, Kowalska I, Straczkowski M, Testar X, Palacín M, Sandri M, Serrano AL and Zorzano A.
    J Clin Invest, 124 (5), 1914-27 (2014)
    Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc
    Rosell A, Meury M, Álvarez-Marimon E, Costa M, Pérez-Cano L, Zorzano A, Fernández-Recio J, Palacín M and Fotiadis D.
    P Natl Acad Sci Usa, 111 (8), 2966-71 (2014)
    Two novel mutations in the BCKDK (branched-chain keto-acid dehydrogenase kinase) gene are responsible for a neurobehavioral deficit in two pediatric unrelated patients
    García-Cazorla A, Oyarzabal A, Fort J, Robles C, Castejón E, Ruiz-Sala P, Bodoy S, Merinero B, Lopez-Sala A, Dopazo J, Nunes V, Ugarte M, Artuch R, Palacín M, Rodríguez-Pombo P, Alcaide P, Navarrete R, Sanz P, Font-Llitjós M, Vilaseca MA, Ormaizabal A, Pristoupilova A and Agulló SB.
    Hum Mutat, 35 (4), 470-7 (2014)
    Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice
    Di Giacopo A, Rubio-Aliaga I, Cantone A, Artunc F, Rexhepaj R, Frey-Wagner I, Font-Llitjós M, Gehring N, Stange G, Jaenecke I, Mohebbi N, Closs EI, Palacín M, Nunes V, Daniel H, Lang F, Capasso G and Wagner CA.
    Am J Physiol-renal, 305 (12), F1645-55 (2013)
    Mfn2 modulates the UPR and mitochondrial function via repression of PERK
    Muñoz JP, Ivanova S, Sánchez-Wandelmer J, Martínez-Cristóbal P, Noguera E, Sancho A, Díaz-Ramos A, Hernández-Alvarez MI, Sebastián D, Mauvezin C, Palacín M and Zorzano A.
    Embo J, 32 (17), 2348-61 (2013)
    The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1
    Bodoy S, Fotiadis D, Stoeger C, Kanai Y and Palacín M.
    Mol Aspects Med, 34 (2-3), 638-45 (2013)
    The SLC3 and SLC7 families of amino acid transporters
    Fotiadis D, Kanai Y and Palacín M.
    Mol Aspects Med, 34 (2-3), 139-58 (2013)
    T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control
    Mariotta L, Ramadan T, Singer D, Guetg A, Herzog B, Stoeger C, Palacín M, Lahoutte T, Camargo SM and Verrey F.
    J Physiol-London, 590 (Pt 24), 6413-24 (2012)
    Molecular basis of substrate-induced permeation by an amino acid antiporter
    Kowalczyk L, Ratera M, Paladino A, Bartoccioni P, Errasti-Murugarren E, Valencia E, Portella G, Bial S, Zorzano A, Fita I, Orozco M, Carpena X, Vázquez-Ibar JL and Palacín M.
    P Natl Acad Sci Usa, 108 (10), 3935-40 (2011)
    Role of transmembrane domain 8 in substrate selectivity and translocation of SteT, a member of the L-amino acid transporter (LAT) family
    Bartoccioni P, Del Rio C, Ratera M, Kowalczyk L, Baldwin JM, Zorzano A, Quick M, Baldwin SA, Vázquez-Ibar JL and Palacín M.
    J Biol Chem, 285 (37), 28764-76 (2010)
    Pathophysiology and treatment of cystinuria
    Chillarón J, Font-Llitjós M, Fort J, Zorzano A, Goldfarb DS, Nunes V and Palacín M.
    Nat Rev Nephrol, 6 (7), 424-34 (2010)
    Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes
    Zorzano A, Liesa M and Palacín M.
    Int J Biochem Cell B, 41 (10), 1846-54 (2009)
    The molecular machinery of mitochondrial fusion and fission: An opportunity for drug discovery?
    Zorzano A, Sebastián D, Segalés J and Palacín M.
    Curr Opin Drug Disc, 12 (5), 597-606 (2009)
    Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pancreatic diversion in morbidly obese individuals with normal glucose tolerance but not in type 2 diabetic patients
    Hernández-Alvarez MI, Chiellini C, Manco M, Naon D, Liesa M, Palacín M, Mingrone G and Zorzano A.
    Diabetologia, 52 (8), 1618-27 (2009)
    Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter
    Bippes CA, Zeltina A, Casagrande F, Ratera M, Palacin M, Muller DJ and Fotiadis D.
    J Biol Chem, 284 (28), 18651-63 (2009)
    Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily
    Casagrande F, Ratera M, Schenk AD, Chami M, Valencia E, Lopez JM, Torrents D, Engel A, Palacin M and Fotiadis D
    J Biol Chem, 283 (48), 33240-48 (2008)
    Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype
    Bartoccioni P, Rius M, Zorzano A, Palacín M and Chillarón J
    Hum Mol Genet, 17 (12), 1845-54 (2008)
    The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane
    Fort J, de la Ballina LR, Burghardt HE, Ferrer-Costa C, Turnay J, Ferrer-Orta C, Usón I, Zorzano A, Fernández-Recio J, Orozco M, Lizarbe MA, Fita I and Palacín M.
    J Biol Chem, 282 (43), 31444-52 (2007)
    Functional and structural characterization of the first prokaryotic member of the L-amino acid transporter (LAT) family: a model for APC transporters
    Reig N, del Rio C, Casagrande F, Ratera M, Gelpí JL, Torrents D, Henderson PJ, Xie H, Baldwin SA, Zorzano A, Fotiadis D and Palacín M
    J Biol Chem, 282 (18), 13270-81 (2007)
    The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters
    Fernández E, Jimenez-Vidal M, Calvo M, Zorzano A, Tebar F, Palacin M and Chillaron J
    Biol Chem, 281 26552-61 (2006)
    Full publication list