Maria J. Macias

Research Group:

Structural Characterization of Macromolecular Assemblies

Unit:

MECHANISMS OF DISEASE

Position:

Group Leader

Office:

EM01B41-42

Telephone:

+34 93 40 37189

Email:

maria.macias@irbbarcelona.org

ICREA Research Professor

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Born in Zamora, Spain, in 1964. Degree in Chemistry from the University of Salamanca, Spain (1989). Currently working at the Department of Structural and Computational Biology at the Institute for Research in Biomedicine –IRB Barcelona.

Ph.D. student in the group of Prof. Manuel Grande Benito, Dep. of Organic Chemistry Facultad de Ciencias Químicas, University of Salamanca (1989-1993). Postdoctoral Fellow in the group of Prof. Hartmut Oschkinat, department of structures and biocomputing EMBL, Heidelberg (Germany, 1993-98). Staff-Scientist l EMBL, department of structures and biocomputing EMBL, Heidelberg (Germany 1998-2002). ICREA researcher at the Institute for the Research in Biomedicine –IRB (Since 2002 till present).

Research activity focus on the Structural characterization of biomolecules by Nuclear Magnetic resonance.

Meet our scientists Videos

Maria Macias: "Insights into the puzzle of life"

Selected group publications

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

Aragón E, Wang Q, Zou Y, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Gomes T, Márquez JA, Hadjantonakis AK, Macias MJ and Massagué J.

Gene Dev, 33 (21-22), 1506-1524 (2019)

TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling

Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A and Macias MJ.

Nucleic Acids Res, 46 (17), 9220-9235 (2018)

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J and Macias MJ.

Nat Commun, 8 (1), 2070 (2017)

Preventing fibril formation of a protein by selective mutation

Maisuradze GG, Medina J, Kachlishvili K, Krupa P, Mozolewska MA, Martin-Malpartida P, Maisuradze L, Macias MJ and Scheraga HA.

P Natl Acad Sci Usa, 112 (44), 13549-54 (2015)

Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation

Schelhorn C, Martín-Malpartida P, Suñol D and Macias MJ.

Sci Rep, 5 14990 (2015)

Structural determinants of Smad function in TGF-β signaling

Macias MJ, Martin-Malpartida P and Massagué J.

Trends Biochem Sci, 40 (6), 296-308 (2015)

Structure of the N-terminal domain of the protein Expansion: an `Expansion' to the Smad MH2 fold

Beich-Frandsen M, Aragón E, Llimargas M, Benach J, Riera A, Pous J and Macias MJ.

Acta Crystallogr D, 71 (Pt 4), 844-53 (2015)

RNA recognition and self-association of CPEB4 is mediated by its tandem RRM domains

Schelhorn C, Gordon JM, Ruiz L, Alguacil J, Pedroso E and Macias MJ.

Nucleic Acids Res, 42 (15), 10185-95 (2014)

Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways

Aragón E, Goerner N, Xi Q, Gomes T, Gao S, Massagué J and Macias MJ.

Structure, 20 (10), 1726-36 (2012)

Fine-tuning the π-π aromatic interactions in peptides: somatostatin analogues containing mesityl alanine

Martín-Gago P, Gomez-Caminals M, Ramón R, Verdaguer X, Martin-Malpartida P, Aragón E, Fernández-Carneado J, Ponsati B, López-Ruiz P, Cortes MA, Colás B, Macias MJ and Riera A.

Angew Chem Int Edit, 51 (8), 1820-5 (2012)

SSTR1- and SSTR3-Selective Somatostatin Analogues

Ramón R, Martín-Gago P, Verdaguer X, Macias MJ, Martin-Malpartida P, Fernández-Carneado J, Gomez-Caminals M, Ponsati B, López-Ruiz P, Cortés MA, Colás B and Riera A.

Chembiochem, 12 (4), 625-32 (2011)

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

Aragón E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J and Macias MJ.

Gene Dev, 25 (12), 1275-88 (2011)

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P and Massagué J.

Mol Cell, 36 (3), 457-68 (2009)

NMR structural studies on human p190-A RhoGAPFF1 revealed that domain phosphorylation by the PDGF-receptor alpha requires its previous unfolding

Bonet R, Ruiz L, Aragón E, Martín-Malpartida P and Macias MJ.

J Mol Biol, 389 (2), 230-7 (2009)

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D and Massagué J.