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About
Maria J. Macias
Research Group:
Structural Characterization of Macromolecular Assemblies
Unit:
MECHANISMS OF DISEASE
Position:
Group Leader
Office:
EM01B41-42
Telephone:
+34 93 40 37189
Email:
maria.macias@irbbarcelona.org
ICREA Research Professor
View research group
Meet our scientists Videos
Maria Macias: "Insights into the puzzle of life"
Selected group publications
Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
Aragón E, Wang Q, Zou Y, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Gomes T, Márquez JA, Hadjantonakis AK, Macias MJ and Massagué J.
Gene Dev,
33
(21-22), 1506-1524 (2019)
TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A and Macias MJ.
Nucleic Acids Res,
46
(17), 9220-9235 (2018)
Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J and Macias MJ.
Nat Commun,
8
(1), 2070 (2017)
Preventing fibril formation of a protein by selective mutation
Maisuradze GG, Medina J, Kachlishvili K, Krupa P, Mozolewska MA, Martin-Malpartida P, Maisuradze L, Macias MJ and Scheraga HA.
P Natl Acad Sci Usa,
112
(44), 13549-54 (2015)
Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation
Schelhorn C, Martín-Malpartida P, Suñol D and Macias MJ.
Sci Rep,
5
14990 (2015)
Structural determinants of Smad function in TGF-β signaling
Macias MJ, Martin-Malpartida P and Massagué J.
Trends Biochem Sci,
40
(6), 296-308 (2015)
Structure of the N-terminal domain of the protein Expansion: an `Expansion' to the Smad MH2 fold
Beich-Frandsen M, Aragón E, Llimargas M, Benach J, Riera A, Pous J and Macias MJ.
Acta Crystallogr D,
71
(Pt 4), 844-53 (2015)
RNA recognition and self-association of CPEB4 is mediated by its tandem RRM domains
Schelhorn C, Gordon JM, Ruiz L, Alguacil J, Pedroso E and Macias MJ.
Nucleic Acids Res,
42
(15), 10185-95 (2014)
Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways
Aragón E, Goerner N, Xi Q, Gomes T, Gao S, Massagué J and Macias MJ.
Structure,
20
(10), 1726-36 (2012)
Fine-tuning the π-π aromatic interactions in peptides: somatostatin analogues containing mesityl alanine
Martín-Gago P, Gomez-Caminals M, Ramón R, Verdaguer X, Martin-Malpartida P, Aragón E, Fernández-Carneado J, Ponsati B, López-Ruiz P, Cortes MA, Colás B, Macias MJ and Riera A.
Angew Chem Int Edit,
51
(8), 1820-5 (2012)
SSTR1- and SSTR3-Selective Somatostatin Analogues
Ramón R, Martín-Gago P, Verdaguer X, Macias MJ, Martin-Malpartida P, Fernández-Carneado J, Gomez-Caminals M, Ponsati B, López-Ruiz P, Cortés MA, Colás B and Riera A.
Chembiochem,
12
(4), 625-32 (2011)
A Smad action turnover switch operated by WW domain readers of a phosphoserine code
Aragón E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J and Macias MJ.
Gene Dev,
25
(12), 1275-88 (2011)
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P and Massagué J.
Mol Cell,
36
(3), 457-68 (2009)
NMR structural studies on human p190-A RhoGAPFF1 revealed that domain phosphorylation by the PDGF-receptor alpha requires its previous unfolding
Bonet R, Ruiz L, Aragón E, Martín-Malpartida P and Macias MJ.
J Mol Biol,
389
(2), 230-7 (2009)
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D and Massagué J.
Cell,
139
(4), 757-69 (2009)
NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands
Morales B, Ramirez-Espain X, Shaw AZ, Martin-Malpartida P, Yraola F, Sánchez-Tilló E, Farrera C, Celada A, Royo M and Macias MJ
Structure,
15
473-83 (2007)
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