Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.
A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.
The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.
The newspaper La Tribuna de Albacete has interviewed IRB Barcelona researcher Erika López Arribillaga about a grant awarded to her on 24 September by the Spanish Association Against Cancer (AECC). López Arribillaga’s project aims to unravel the long-term effects of some chemotherapy treatments on colorectal cancer patients.
Link to La Tribuna de Albacete
The newspapers El Mundo, La Vanguardia and Diari Ara, the TV station TV3 and the radio stationsCatalunya Ràdio andRAC1, among other media, have echoed on a study by the Biomedical Genommics lab, headed by Núria López, published in Nature Genetics. The study has for the first time determined the genetic mutations caused by various therapies used to treat cancer. “Studying the DNA damage caused by chemotherapies in patients’ cells is the first step towards understanding the relation between these mutations and the long-term side effects of these treatments,” says Oriol Pich, PhD student at IRB Barcelona and first author of the...
Scientists at IRB Barcelona determine the genetic alterations in the cells of cancer patients caused by the main cancer therapies.
This is an important step towards understanding the long-term side effects and optimizing treatments against cancer.
The results have been published in the journal Nature Genetics.
Salvador Aznar-Benitah has received a grant in the AECC Project category.
Two postdoctoral fellowships have been awarded to researchers Magdolna Djurec and Erika López Arribillag.
Catalunya Ràdio, El Punt Avui, Expansión Catalunya, Europa Press, EFE, among other media, have published an article about the launch of the #MetastasisChallenge campaign. Through this initiative, the Institute for Research in Biomedicine (IRB Barcelona) calls society to action to support research into metastasis—the main cause of death from cancer—by raising €5 M over the next four years.
Link to El Punt Avui
Through the campaign called #MetastasisChallenge, the centre aims to raise €5 M over the next four years.
Metastasis is responsible for 90% of deaths from cancer, and this campaign aims to rally social support for research in order to speed up discoveries.
On the occasion of the "International Day of Women and Girls in Science", the web portal Núvol has published an article highlighting 25 women researchers who are developing leading projects in science and technology in Spain. One of them is Núria López-Bigas, head of the Biomedical Genomics Laboratory at IRB Barcelona, who studies cancer from a genomic perspective and develops computational methods to identify the genetic mutations responsible for the development of tumours.
Link to Núvol
IRB Barcelona hosts the workshop “Standing up for Science”, for young researchers interested in public outreach activities.
Organised by the European organisation Sense About Science, the workshop involved more than 50 researchers, including members of IRB Barcelona, from various countries.
The Institute will be giving a workshop entitled “Deciphering the code of cancer”