This work is a collaboration between Núria López-Bigas’ lab at IRB Barcelona and the groups headed by Anna Bigas (Hospital del Mar Medical Research Institute) and Josep Maria Ribera (Josep Carreras Leukaemia Research Institute).
The results have been published in Genome Biology.
Analysis of the genomes of 28,000 tumours from 66 types of cancer has led to the identification of 568 cancer driver genes
Performed by the Biomedical Genomics Lab at IRB Barcelona, the study has allowed a major update of the Integrative OncoGenomics (IntOGen) platform, aimed at identifying mutational cancer driver genes.
Published in Nature Reviews Cancer, the results provide the most complete snapshot of the compendium of cancer driver genes to date.
Oriol Pich is a PhD student in IRB Barcelona’s Biomedical Genomics Laboratory, led by Núria López-Bigas. After being awarded a degree in Medicine (Bachelor in Surgery - MBBS) from the University of Barcelona in 2016 and a Bachelor of Business Administration by the Open University of Catalonia (UOC) in 2017, he decided to pursue a PhD in Computational Biology at IRB Barcelona. He thinks that big data in biology will have an impact on patients’ welfare and feels that he could help to bridge the two fields.
His main topic of interest is cancer genomics, whereby using next-generation...
DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours, as lesions pass on unrepaired over several rounds of cell division.
A study by the Liver Cancer Evolution Consortium explores the evolution of tumours after chemical damage, offering interesting insights into how mutational processes work.
The work has been published in the journal Nature.
Various media channels have reported on the Pan-Cancer Project, which has involved the Biomedical Genomics Lab at the Institute for Research in Biomedicine (IRB Barcelona).
The journal Nature has published a set of 23 articles that describe the most comprehensive genomic map of 38 types of cancer to date. “It’s the first time that the complete genomes of tumours has been sequenced,” says Abel González, researcher in IRB Barcelona’s Biomedical Genomics Lab.
SER radio station has also interviewed Núria López-Bigas, head of the aforementioned lab. The researcher explains that one of the conclusions of the study is that “cancer is a genetic disease—a disease...
Several media have reported on the presentation ceremony of the ‘Doctores Diz Pintado’ National Cancer Prize, in which Núria López-Bigas, head of the Biomedical Genomics Lab at IRB Barcelona, received her award. During the event, López-Bigas called for all political parties to sign "a national pact for science involving long-term decisions".
According to the scientist, "Governments are in power for short period of time, 4 years at the most, but science is a long-term national and social investment and it must not be conditioned by which party is governing or if we have new elections”.
Each year the Fundación de Investigación del Cáncer de la Universidad de la Salamanca (FICUS) - Centro de Investigación del Cáncer (CIC) presents the 'Doctores Diz Pintado' Prize with the aim to promote and acknowledge the contribution of young Spanish researchers to Cancer Research.
The newspapers La Gaceta de Salamanca and Tribuna Universitaria have interviewed Núria López-Bigas, ICREA researcher and head of the Biomedical Genomics Lab at the Institute for Research in Biomedicine (IRB Barcelona), on the occasion of the award of the “Doctores Diz Pintado” Prize, which she will receive in person on 28 January. López-Bigas is the first female scientist to be presented with this prize. Referring to this point, the researcher says, “It is an honour to receive the prize. Being the first woman to do so highlights just how much work has to be done to achieve equality with respect to appraisement and visibility”.
The newspaper La Vanguardia has reported on the award of the “Doctores Diz Pintado” National Cancer Research Prize, to Núria López-Bigas ICREA researcher at the Institute for Research in Biomedicine (IRB Barcelona) in recognition of her work on the accumulation of mutations in the genome. Referring to López-Bigas, the jury highlighted "the relevance and impact of her work, which focuses on genomics and has wide applications in personalised medicine."
Link to: La Vanguardia...