The electric polarizability of DNA is a fundamental property that directly influences its biological functions. Despite the importance of this property, however, its measurement has remained elusive so far.
In a study published in PNAS today, researchers at Barcelona’s Institute for Bioengineering of Catalonia (IBEC) led by Laura Fumagalli, senior researcher at IBEC and lecturer at the University of Barcelona, and their collaborators at the Institute for Research in Biomedicine (IRB) and at Barcelona Supercomputing Center (BSC), and at Centro Nacional de Biotecnologia (CNB-CSIC) and IMDEA Nanociencia in Madrid, describe how they have found a way to directly measure DNA electric polarizability – represented by its dielectric constant, which indicates how a material reacts to an applied electric field – for the first time ever.
Genetic Engineering & Biotechnology News (GEN) devotes a news item to the recent study by IRB Barcelona scientists Xavier Salvatella and Modesto Orozco.
Published in Nature Communications, the study reports the team's discovery that the motions of various parts of proteins, although physically far apart, are correlated. Such findings hint at another way to think about drug development.
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A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.
This initiate is aimed at young undergraduate students and graduates in statistics, mathematics, informatics, and bioinformatics interested in the biosciences.
Maths4Life involves tutored summer training placements in labs working in cancer, network biology, molecular modelling and biostatistics.
Researchers at IRB, Jordi Duran and Modesto Orozco, have been consulted by the journalist Cristina Sáez for an article on memory for the Magazine of "La Vanguardia".
Jordi Duran, associate researcher with Joan Guinovart's group, studies the implications of glycogen on memory function and learning. Modesto Orozco, an expert in biocomputation, is one of the researchers involved in the Human Brain Project, the European initiative that seeks to simulate how the brain works within the next 10 years.
Read the article in La Vanguardia (...
The local scientific programme “El problema de Gettier”, from la Xarxa TV, interviews Modesto Orozco about bioinformatics and biosimulation. The IRB expert believes that in the future doctors will have simulation models of each patient that will help to predict disease progression.
Link to “ El problema de Gettier”.
BSC, CRG, and IRB sign a collaboration agreement for five years that will promote Barcelona as a world leader in computational biology.
The goals of this joint programme are to retain the critical mass of researchers, to attract talent, and to boost computational biology.
The team includes ten well-known researchers headed by Modesto Orozco (IRB), Roderic Guigó (CRG), and David Torrents (BSC).
The Spanish television channel “La 2” broadcasted a programme funded by the Botín Foundation about several of the projects it supports, among them two "Mind the Gap" technology transfer projects belonging to IRB Barcelona. Eduard Batlle and Elena Sancho talk about "Colostage" and Modesto Orozco about "Nostrum Drug Discovery".
Salvador Aznar-Benitah, Angel R. Nebreda, Modesto Orozco, and Manuel Palacín are beneficiaries of funds raised in the 2012 “Marató” destined to fight cancer.
The IRB Barcelona projects—one individual and three coordinated—are to receive approx. 1.2 M€.
Having raised more than 11 M€, “La Fundació” will financially support 47 projects carried out by 79 researchers over the next three years.