Results about: 3D imaging
Ground-breaking research sometimes arises as a result of coincidence, multidisciplinarity and, of course, perseverance. Biochemist Oriol Gallego (Barcelona, 1978) is a Ramón y Cajal Research Associate in Raúl Méndez’s Translational Control of Cell Cycle and Differentiation Lab. Oriol led a promising study that has just been published in Cell. Combining genetic engineering, super-resolution microscopy, and biocomputation, he was able to see a 3D “protein nanomachine” in a living yeast cell. This breakthrough paves the way for inspiring future discoveries, such as the live observation of how viruses use protein complexes to infect cells.
Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3D the protein machinery inside living cells
Published in the journal Cell, the study unveils key functional features of an assembly of proteins that is vital for animals and plants.
With this new strategy in hand, it will be possible to study cellular protein machinery in health and in disease.
The new microscopes allow the tracking of cell movement within an organism, observation of neuronal synapses, visualization of the spread of cancer, and in vivo monitoring of embryo development.
The development of the 3D microscopy, super-resolution microscopy, and light sheet microscopy (a kind of microscope that illuminates the sample with a sheet of light) pushes biology towards new horizons.
IRB Barcelona and the Centre for Genomic Regulation (CRG) gather 420 experts in the 15th ELMI Meeting, an annual European microscopy congress held this year in Sitges from 19 till 22 May.