Results about: aminoacyl-tRNA synthetases

Our research addresses the evolution of the protein synthesis machinery, the molecular interactions that regulate it, and the biomedical applications that can be derived from its study. Our research projects are focused around the biology of transfer RNA (tRNA).

Discovery of a fundamental limit to the evolution of the genetic code

A study performed at IRB Barcelona offers an explanation as to why the genetic code, the dictionary used by organisms to translate genes into protein, stopped growing 3,000 million years ago.

The reason is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins.

The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life.

The discovery could have applications in synthetic biology.

Analogues of a natural product are drug candidates against malaria

Researchers at IRB Barcelona identify a family of efficient and selective molecules to combat the parasite Plasmodium, causal agent of malaria.

Two analogues of borrelidin were found to cure 100% of infected mice and produce immunological memory in these animals, a property not previously observed in an antimalarial drug.

Growing resistance to current treatment for malaria increases the need for new drug candidates.