Results about: cancer genomics
Part of the European Research Council’s reasoning for providing their coveted Starting Grants is to “provide top talent with good conditions at the right time to thrive.” For the team led by Fran Supek (b. Zagreb, Croatia, 1981), the right time has just arrived with the award of a Starting Grant worth 1.5 million euros of funding. His project, called HYPER-INSIGHT, was among the 13% of successful proposals of the 3,085 applications made to the 2017 ‘Starting Grants’ Call.
ERC Starting Grants support young talented researchers over 5 years.
The IRB Barcelona group leader will focus on the genomes of hypermutated tumours to detect cancer vulnerabilities.
Fran Supek (IRB Barcelona) and Ben Lehner (CRG) identify important processes that create mutations that cause cancer by studying the genomes of more than 1,000 tumors.
Many mutations in human cancers are caused by mistakes made by a repair mechanism or ‘DNA spellchecker’ rather than the actual damage to DNA caused by the environment.
Sunlight and alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes.