Results about: cancer
Researchers at IRB Barcelona identify a possible therapeutic target for Kennedy´s disease and prostate cancer
Activation of the chaperone protein Hsp70 leads to a decrease in the formation of androgen receptor aggregates, which give rise to muscular atrophy in patients with Kennedy´s disease, a rare condition for which no treatment is available.
The results may also be useful in the search for a treatment for castration-resistant prostate cancer, a disease that causes 30,000 death a year in Europe and for which there is no treatment.
The study, which has been published in Nature Communications, is a collaboration with the University of California San Francisco and the University of Michigan.
Many treatments against cancer, such as TRAIL, aim to trigger a type of cell death known as apoptosis.
A team at IRB Barcelona, headed by Antonio Zorzano, has demonstrated that the protein TP53INP2 induces apoptosis in chemotherapy treatments.
Through the campaign called #MetastasisChallenge, the centre aims to raise €5 M over the next four years.
Metastasis is responsible for 90% of deaths from cancer, and this campaign aims to rally social support for research in order to speed up discoveries.