Results about: cancer

Researchers discover a mechanism that inhibits the Smad signalling pathway

  • A group of scientists headed by Maria Macias, ICREA researcher at IRB Barcelona, describes the mechanism through which TGIF1 inhibits the activity of Smad proteins.
  • The study, which used molecular and structural biology techniques to analyse this interaction, has been published in Nucleic Acids.

Acidic pH: the weakness of cancer cells

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH.

The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.

Researchers design a nano-carrier to release drugs into damaged cells

A team headed by Manuel Serrano at IRB Barcelona has designed a drug encapsulation system that selectively targets senescent cells.

The study paves the way for therapeutic approaches to eliminate senescent cells in many diseases, such as pulmonary fibrosis and cancer.

Big Data analysis identifies new cancer risk genes

Researchers at the Centre for Genomic Regulation (CRG) in collaboration with IRB Barcelona, developed a new method to systematically identify genes contributing to heritable cancer risk.

The study, published in Nature Communications, is a success story for data sharing and openness in science.

Enzyme may be a therapeutic target for breast cancer and brain condition

A new study in collaboration with the Genomic Instability and Cancer Laboratory at IRB Barcelona and led by the University of Copenhagen,  reveals that TLK2 displays lower levels of activity in intellectual disability and that it is possible to inhibit it in breast cancer, where it is overactive.

The study suggests that the enzyme may be a target for potential therapies.