Results about: colon

<p>Angel R Nebreda</p>

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:

IRB Barcelona receives the support of the ERC to develop a test to predict metastasis of colon and liver cancer

Eduard Batlle, ICREA researcher at IRB Barcelona, will head the project “COLOStage”, which has been awarded European funding for technology transfer.

This “Proof of Concept” call has received applications from 128 projects, 28% of which have been granted funding.

The colon has a safety mechanism that restricts tumour formation

When adenomas appear in the colon, the same cells of the tissue produce a molecule that neutralizes its progression.

Adenomas, which are highly prevalent in the population, provide the substrate on which carcinomas develop.

Researchers at IRB discover a key regulator of colon cancer

The team headed by Angel Rodríguez Nebreda, ICREA researcher at IRB, identifies for the first time in mice that the p38 MAPK protein is required for the survival and proliferation of colon cancer cells.

In the same study the scientists demonstrate that a p38 inhibitor that has been used in clinical trials for inflammatory diseases shrinks the tumours in mice.

The study, published today in Cancer Cell, has received funding from the BBVA Foundation, the European project InflaCare, the Spanish Government, and the European Research Council (ERC).