Results about: epigenetics

Understanding the molecular origin of epigenetic markers

Researchers at IRB Barcelona discover the molecular mechanism that determines how epigenetic markers influence gene expression

Discovery of an unexpected function of a protein linked to neurodegenerative diseases

A study done on fruit flies and published in Nature Communications reveals that the protein dDsk2, in addition to degrading proteins, also plays a key role in regulating gene expression.

This protein is also present in humans and is known to be mutated in several neurodegenerative diseases, including Alzheimer’s. But the mechanism by which these mutations contribute to the development of disease remains unclear.

IRB Barcelona is to start a study to examine the relationship between dDsk2 mutations and neurodegenerative diseases.

ChroGPS, a new generation visual browser of the epigenome

This is a software application that provides easily interpretable maps from which to analyse and understand the immense volume of epigenetic and genetic data available.

The work is the fruit of collaboration between biostatisticians, biocomputational researchers and molecular biologist at IRB Barcelona. The capacity of ChroGPS is described in an article in Nucleic Acids Research.

Experts are convinced that epigenetics has a key role in the fight against cancer

First event in the series “Barcelona Conferences on Epigenetics and Cancer: Challenges, Opportunities and Perspectives”, promoted by CRG, IBMB-CSIC, IMPPC, IDIBELL and IRB Barcelona.

And in the beginning was histone 1

A team at IRB Barcelona identifies an essential protein for embryonic viability during the first cell divisions in the fly Drosophila.

This protein, called dBigH1, which is a variant of histone 1, could also be associated with fertility issues.