Results about: Gene expression

Recent years have seen a paradigm shift in our understanding of gene activity and regulation. It is now clear that processing of primary transcripts as well as translational control open a myriad of opportunities for gene regulation, which are extensively used in virtually every human gene.

BigH1—the key histone for male fertility

Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.

The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility.

Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.

A study reveals the biological changes in breast cancer between the primary tumour and metastases

Researchers at IDIBAPS and IRB Barcelona have described in Cancer Research, that the longer the time from the onset of the tumour to the development of metastasis is, the more aggressive this cancer becomes.

Doctors and scientists need to speak the same language, say two new PhD4MD fellows

What prompts two medical doctors, after six years of training and five years of specialisation, to pursue a PhD? It’s simple: translational medicine.

Discovery of a gene associated with a set of poorly understood rare diseases

IRB Barcelona identifies GEMC1 as a master gene for the generation of multiciliated cells—cells with fine filaments that move fluids and substances—which are found exclusively in the brain, respiratory tract, and reproductive system.

Defects in multiciliated cells lead to ciliopathies—rare and complex diseases that are poorly understood and for which not all causative genes have been identified.

And in the beginning was histone 1

A team at IRB Barcelona identifies an essential protein for embryonic viability during the first cell divisions in the fly Drosophila.

This protein, called dBigH1, which is a variant of histone 1, could also be associated with fertility issues.