Results about: obesity

Researchers at IRB Barcelona discover that the liver and brain communicate in order to regulate appetite

Mice eat less when their hepatic glucose stores are high.

“We have to find treatments to increase hepatic glucose because of its positive effect in diabetes and obesity,” says Joan Guinovart, head of the study published in Diabetes.

Researchers identify a key molecule in flies that adjusts energy use under starvation conditions

Scientists at IRB Barcelona have observed that, when deprived of food, flies that do not express p53 show poor management of energy store.

The study, published today in Cell Reports, further supports the involvement of this molecule—traditionally associated with tumour suppression—in metabolism.

The researchers provide new insights to study p53 function in metabolic diseases such as diabetes and obesity.

ICREA Academia Award for Antonio Zorzano

IRB hosts 13 researchers who have received the ICREA seal of recognition

Alterations in the interactions between organelles within neurons cause obesity

Researchers at IRB Barcelona participate in a study headed by IDIBAPS that sheds light on the molecular causes of obesity.

The control of hunger and body weight is governed by the central nervous system, and the region called the hypothalamus plays a crucial role. In normal conditions, the hormone leptin suppresses appetite and reduces body weight by activating the POMC neurons of the hypothalamus.

In obesity there is leptin resistance and this hormone loses its capacity to exert its effects on appetite and weight. The neurobiological causes of this alteration are among the main enigmas in the field of obesity research.

This study describes a molecular mechanism in POMC neurons that explains how leptin resistance comes about and how appetite control becomes disrupted.