Results about: proteins

Discovery of a fundamental limit to the evolution of the genetic code

A study performed at IRB Barcelona offers an explanation as to why the genetic code, the dictionary used by organisms to translate genes into protein, stopped growing 3,000 million years ago.

The reason is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins.

The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life.

The discovery could have applications in synthetic biology.

The transmission of information via proteins could revolutionize drug discovery

A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.

Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.