Results about: stem cells

Ageing is exacerbated by alterations of stem cell circadian rhythm

Stem cell functions continue to be governed by day and night cycles (circadian rhythms) during ageing, but their rhythms become devoted to tissue repair and not to the maintenance of tissue tone.

The two studies published in Cell and headed by Salvador Aznar Benitah at IRB Barcelona reject the scientific dogma associating ageing with the loss of stem cell circadian rhythm.

A low-calorie diet delays alterations in the rhythmic functions of stem cells and slows down ageing.

A genome-editing strategy to study cancer stem cells in human tumours

In EMBO Molecular Medicine, IRB Barcelona scientists report a technique based on a combination of CRISPR/Cas9 genome editing and patient-derived tumour organoids that allows the study of cell heterogeneity in human tumours.

The novel approach was used to examine the behaviour of colorectal cancer stem cells by tracing specific marker genes.

The intestine has a reservoir of stem cells that are resistant to chemotherapy

These comprise a small group of passive stem cells—quiescent—that are activated when needed and have the capacity to produce any kind of intestinal cell.

Quiescent cells are relevant for tissue regeneration and for their participation in tumour development.

“My objective? To generate new knowledge, reach the limits, and fight against uncertainty and frustration”

After eight years, Francisco Barriga is ready for a new stage in his scientific career. He says that IRB Barcelona “shaped” him as a scientist and that he “learnt to ask the right scientific questions.” But he also got involved in many outreach activities. “Over the years, I have never met anyone who did not find what we do interesting. We just need to find the right way to talk about it,” he says.