Results about: TGF-beta signalling

Researchers discover a mechanism that inhibits the Smad signalling pathway

  • A group of scientists headed by Maria Macias, ICREA researcher at IRB Barcelona, describes the mechanism through which TGIF1 inhibits the activity of Smad proteins.
  • The study, which used molecular and structural biology techniques to analyse this interaction, has been published in Nucleic Acids.

Understanding the adaptability of Smads

A study published in Nature Communications and led by Maria J Macias highlight new DNA motifs for the Smads proteins.

Discovery of the genetic fingerprint of aggressive colon tumours

A study published in Nature Genetics by researchers at IRB Barcelona explains the basis for the classification of colon tumours in good or bad prognosis by analysing the tissue surrounding the tumour cells.

The scientists are currently developing a test that enables the identification of patients at risk of relapse after surgical removal of the tumour by measuring 4-6 genes expressed by the tumour microenvironment.

The researchers also propose to test in patients a particular drug that blocks the metastatic capacity of colorectal cancers in mice.

This drug has been tested using novel technology that allows the growth of mini colon cancers, also known as organoids, derived from patient samples.

Amongst the best in cancer and metastasis studies

The journal Cancer Cell ranks the article on colon cancer metastasis by Eduard Batlle and Elena Sancho among the best 10 in 2012.