Cell and Developmental BiologyCell division laboratory

Cell division laboratory

We use Drosophila to unveil the basic principles that govern cell proliferation and malignant growth. We model cancer in flies to understand the cellular changes that drive malignant growth and to identify conserved mechanisms that might be relevant for human cancer therapy. We make use of a multidisciplinary approach that combines genetics, genomics, molecular biology and advanced microscopy.

We focus on the mechanisms of malignant transformation in Drosophila larval brains. We have found that neural stem cells originate tumours when the delicately balanced process of self-renewing asymmetric division is disrupted.

We have found that some tumour types are driven by the ectopic expression of germline proteins.

We develop and make extensive use of advanced microscopy techniques. We have demonstrated that the microtubule cytoskeleton of Drosophila neural stem cells is governed by the distinct behaviour displayed by centrosomes in these cells. We have also investigated the molecular details of cilium assembly in Drosophila and have found that, as in humans, basal body fate is reserved to the mother centriole.

We maintain an active line of research to identify new centrosomal proteins and have found some with human orthologs that are linked to human pathologies.

We also work on the mechanisms that bring about genome instability in Drosophila tumours and attempt to establish the extent to which such lesions contribute to tumour progression.

Reina J, Gottardo M, Riparbelli MG, Llamazares S, Callaini G and Gonzalez C.
J Cell Biol, (2018)
Rossi F, Molnar C, Hashiyama K, Heinen JP, Pampalona J, Llamazares S, Reina J, Hashiyama T, Rai M, Pollarolo G, Fernández-Hernández I and Gonzalez C.
Open Biol, 7 (8), (2017)
Gottardo M, Pollarolo G, Llamazares S, Reina J, Riparbelli MG, Callaini G and Gonzalez C.
Curr Biol, 25 (17), 2319-24 (2015)
Rossi F and Gonzalez C.
Nat Protoc, 10 (10), 1525-34 (2015)
Januschke J, Reina J, Llamazares S, Bertran T, Rossi F, Roig J and Gonzalez C.
Nat Cell Biol, 15 (3), 241-8 (2013)
Januschke J, Llamazares S, Reina J and Gonzalez C.
Nat Commun, 2 243 (2011)
Janic A, Mendizabal L, Llamazares S, Rossell D and Gonzalez C.
Science, 330 (6012), 1824-7 (2010)
Caussinus E and Gonzalez C.
Nat Genet, 37 (10), 1125-9 (2005)

This group is financially supported by the following:

  • VI Framework Programme Grants, EU
  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Mutant Drosophila melanogaster spermatozoa. The heads are severed from the tail ends and are dispersed. Photo courtesy of S. Llamazares / Gonzalez Lab</p>
16 May 2018

Al Día Cat, Diario Médico, El Confidencial, Phys.org, Scienmag, entre otros medios nacionales e internacionales, han publicado un artículo acerca de la última investigación liderada por el IRB Barc

<p>Normal Drosophila melanogaster spermatozoa. Orange shows heads and green shows tails. Photo courtesy of S. Llamazares / Gonzalez Lab</p>
11 May 2018

Un equipo liderado por el investigador ICREA del Instituto de Investigación Biomédica (IRB Barcelona), Cayetano González, en colaboración con el grupo de Giuliano Callaini, de la Universidad de Sie

<p>Profesores y científicos trabajando juntos.</p>
17 Mar 2017

Los días 17 y 18 de marzo, quince profesores de secundaria de toda Cataluña tendrán la oportunidad de aprender sobre la mosca del vinagre Drosophila melanogaster, un modelo animal para est

1 Jul 2016

Cayetano González, líder del Laboratorio de División Celular del IRB Barcelona, opina en la revista de divulga

Upcoming events

04 Oct
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Andre Nussenzweig, Ph.D. NIH Distinguished Investigator. Center for Cancer Research National Cancer Institute. Bethesda, Maryland (US)
05 Oct
Aula Fèlix Serratosa, Parc Científic de Barcelona
15 Nov
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Louis Vermeulen MD, PhD. Center for Experimental and Molecular Medicine, Academic Medical Center. Amsterdam. The Netherlands