Cell and Developmental BiologyCell division laboratory

Cell division laboratory

We study the mechanisms of cell division through a multidisciplinary approach that combines genetics, and molecular biology and advanced microscopy. As model systems, we use Drosophila and also cultured cells derived from vertebrates.

Protein Traps: Subcellular localisation is a key aspect of protein function.
We have now automated a protein trap protocol (Reviewed in Gonzalez and Bejarano, 2000) which is being applied in several high-content screens.

Spindle assembly in vivo: Direct visualisation is now mandatory to unravel the complex processes that occur within the living cell. Using protocols developed in our laboratory,  we are obtaining new data on the behaviour of specific proteins labelled with florescent tags (Rebollo and Gonzalez , 2000; Lange et al., 2002; Sampaio et al., 2001; Rebollo et al., 2004).

Molecular analysis of centrosomes. (Lange et al., 2002; Tavosanis and Gonzalez, 2003). We have recently cloned the gene that encodes a centriolar protein. Our laboratory has access to mutant alleles, functional GFP fusions and antibodies, that will be all instrumental tools in the molecular dissection of this organelle.

Modelling cancer in Drosophila: We are starting to use Drosophila to study some basic principles regarding cell proliferation and malignant growth (Caussinus and González, 2005; Wodarz & Gonzalez, 2006. Previews, Cell).

Gonzalez C.
Nature, 528 (7581), 196-7 (2015)
Januschke J, Reina J, Llamazares S, Bertran T, Rossi F, Roig J and Gonzalez C.
Nat Cell Biol, 15 (3), 241-8 (2013)
Januschke J, Llamazares S, Reina J and Gonzalez C.
Nat Commun, 2 243 (2011)
Janic A, Mendizabal L, Llamazares S, Rossell D and Gonzalez C.
Science, 330 (6012), 1824-7 (2010)
Rebollo E, Roldán M and Gonzalez C.
Development, 13 (20), 3393-7 (2009)
Castellanos E, Dominguez P and Gonzalez C.
Curr Biol, 18 (16), 1209-14 (2008)
Caussinus E and Gonzalez C.
Nat Genet, 37 (10), 1125-9 (2005)

This group is financially supported by the following:

  • VI Framework Programme Grants, EU
  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

5 Oct 2015

Various media channels have commented on a study published in Nature Protocols by Fabrizio Rossi, postdoctoral fellow at IRB Barcelona, and Cayetano González, ICREA researcher and group le

15 Sep 2015

A study conducted by ICREA researcher Cayetano González, at the Institute for Research in Biomedicine (IRB Barcelona), and published in Nature Protocols describes a forgot

Upcoming events

23 Feb
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Toni Celià-Terrassa, PhD. Department of Molecular Biology, Princenton University, NJ (USA)
24 Feb
Sala Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Dr. Fanni Gergely, Cancer Research UK Cambridge Institute, University of Cambridge, UK
27 Feb
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Prof. Dr. Donghan Lee, BioNMR Group. Brown Cancer Center University of Louisville. Department of Medicine, University of Louisville, USA