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Cancer Science
Cell Division Laboratory
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González
Group Leader
Telephone:
+34 93 40 37191

ICREA Research Professor, ERC Advanced Grant

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ICREA

Research information

Research interests

We use Drosophila to unveil the basic principles that govern cell proliferation and malignant growth. We model cancer in flies to understand the cellular changes that drive malignant growth and to identify conserved mechanisms that might be relevant for human cancer therapy. We make use of a multidisciplinary approach that combines genetics, genomics, molecular biology and advanced microscopy.

Research lines

We focus on the mechanisms of malignant transformation in Drosophila larval brains. We have found that neural stem cells originate tumours when the delicately balanced process of self-renewing asymmetric division is disrupted.

We have found that some tumour types are driven by the ectopic expression of germline proteins.

We develop and make extensive use of advanced microscopy techniques. We have demonstrated that the microtubule cytoskeleton of Drosophila neural stem cells is governed by the distinct behaviour displayed by centrosomes in these cells. We have also investigated the molecular details of cilium assembly in Drosophila and have found that, as in humans, basal body fate is reserved to the mother centriole.

We maintain an active line of research to identify new centrosomal proteins and have found some with human orthologs that are linked to human pathologies.

We also work on the mechanisms that bring about genome instability in Drosophila tumours and attempt to establish the extent to which such lesions contribute to tumour progression.

Selected publications

Gonzalez C
Current Opinion In Structural Biology
66
( )
178 -
182
(2021)
Molnar C; Heinen JP; Reina J; Llamazares S; Palumbo E; Breschi A; Gay M; Villarreal L; Vilaseca M; Pollarolo G; Gonzalez C
Science Advances
5
(8 )
eaaw7965 -
(2019)
Reina J; Gottardo M; Riparbelli M; Llamazares S; Callaini G; Gonzalez C
Journal Of Cell Biology
217
(7 )
2365 -
2372
(2018)
Rossi F; Molnar C; Hashiyama K; Heinen J; Pampalona J; Llamazares S; Reina J; Hashiyama T; Rai M; Pollarolo G; Fernández-Hernández I; Gonzalez C
Open Biology
7
(8 )
-
(2017)
Rossi F; Gonzalez C
Nature Protocols
10
(10 )
1525 -
1534
(2015)
Gottardo M; Pollarolo G; Llamazares S; Reina J; Riparbelli M; Callaini G; Gonzalez C
Current Biology
25
(17 )
2319 -
2324
(2015)
Pollarolo, Giulia; Gonzalez, Cayetano
Elife
3
(e04869 )
-
(2015)
Januschke, J; Reina, J; Llamazares, S; Bertran, T; Rossi, F; Roig, J; Gonzalez, C
Nature Cell Biology
15
(3 )
241 -
248
(2013)
Januschke J; Llamazares S; Reina J; Gonzalez C
Nature Communications
2
(1 )
243 -
(2011)
Janic A; Mendizabal L; Llamazares S; Rossell D; Gonzalez C
Science
330
(6012 )
1824 -
1827
(2010)

Projects

"Bases moleculares del dimorfismo sexual en el crecimiento maligno" (DROSOSEX), cofinanciado por el Ministerio de Ciencia, Innovación y Universidades- Agencia Estatal de Investigacióny por el Fondo Europeo de Desarrollo Regional (FEDER) de la Unión Europea. Referencia: PGC2018-097372-B-I00

Ministerio de ciencia, innovación y universidades
Agencia estatal de investigación
European union

The molecular basis of the contribution of germline functions to malignant growth in Drosophila somatic cells” (ONCOGERM), cofinanciado por el Ministerio de Economía, Industria y Competitividad - Agencia Estatal de Investigación y el Fondo Europeo de Desarrollo Regional (FEDER) de la Unión Europea. Referencia: BFU2015-66304-P (MINECO/FEDER, UE).

Gobierno de españa
Agencia estatal de investigación
European union

Group members

Postdoctoral Fellow
Postdoctoral Fellow
Postdoctoral Fellow
PhD Student
Research Assistant
Research Assistant

Group News

Innovation
10 Jun 2015