Cell and Developmental BiologyCell division laboratory

Cell division laboratory

We use Drosophila to unveil the basic principles that govern cell proliferation and malignant growth. We model cancer in flies to understand the cellular changes that drive malignant growth and to identify conserved mechanisms that might be relevant for human cancer therapy. We make use of a multidisciplinary approach that combines genetics, genomics, molecular biology and advanced microscopy.

We focus on the mechanisms of malignant transformation in Drosophila larval brains. We have found that neural stem cells originate tumours when the delicately balanced process of self-renewing asymmetric division is disrupted.

We have found that some tumour types are driven by the ectopic expression of germline proteins.

We develop and make extensive use of advanced microscopy techniques. We have demonstrated that the microtubule cytoskeleton of Drosophila neural stem cells is governed by the distinct behaviour displayed by centrosomes in these cells. We have also investigated the molecular details of cilium assembly in Drosophila and have found that, as in humans, basal body fate is reserved to the mother centriole.

We maintain an active line of research to identify new centrosomal proteins and have found some with human orthologs that are linked to human pathologies.

We also work on the mechanisms that bring about genome instability in Drosophila tumours and attempt to establish the extent to which such lesions contribute to tumour progression.

Gonzalez C.
Nature, 528 (7581), 196-7 (2015)
Januschke J, Reina J, Llamazares S, Bertran T, Rossi F, Roig J and Gonzalez C.
Nat Cell Biol, 15 (3), 241-8 (2013)
Januschke J, Reina J, Llamazares S, Bertran T, Rossi F, Roig J and Gonzalez C.
Nat Cell Biol, 15 (3), 241-8 (2013)
Januschke J, Llamazares S, Reina J and Gonzalez C.
Nat Commun, 2 243 (2011)
Janic A, Mendizabal L, Llamazares S, Rossell D and Gonzalez C.
Science, 330 (6012), 1824-7 (2010)
Rebollo E, Roldán M and Gonzalez C.
Development, 13 (20), 3393-7 (2009)
Castellanos E, Dominguez P and Gonzalez C.
Curr Biol, 18 (16), 1209-14 (2008)
Caussinus E and Gonzalez C.
Nat Genet, 37 (10), 1125-9 (2005)

This group is financially supported by the following:

  • VI Framework Programme Grants, EU
  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Teachers and scientists working together.</p>
17 Mar 2017

On 17 and 18 March, fifteen secondary school teachers from around Catalonia will have the opportunity to learn about the fruit fly Drosophila melanogaster, an animal model used to study de

5 Oct 2015

Various media channels have commented on a study published in Nature Protocols by Fabrizio Rossi, postdoctoral fellow at IRB Barcelona, and Cayetano González, ICREA researcher and group le

Upcoming events

29 May - 01 Jun
ESADE Business School, Pedralbes, Pedralbes Building 3, Av. Esplugues 92-96, 08034, Barcelona
31 May
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Nídia de Sousa, PhD student in Development Biology, University of Barcelona.
31 May
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Richa Mudgal - IRB Barcelona