Cell and Developmental BiologyCell division laboratory

Cell division laboratory

We use Drosophila to unveil the basic principles that govern cell proliferation and malignant growth. We model cancer in flies to understand the cellular changes that drive malignant growth and to identify conserved mechanisms that might be relevant for human cancer therapy. We make use of a multidisciplinary approach that combines genetics, genomics, molecular biology and advanced microscopy.

We focus on the mechanisms of malignant transformation in Drosophila larval brains. We have found that neural stem cells originate tumours when the delicately balanced process of self-renewing asymmetric division is disrupted.

We have found that some tumour types are driven by the ectopic expression of germline proteins.

We develop and make extensive use of advanced microscopy techniques. We have demonstrated that the microtubule cytoskeleton of Drosophila neural stem cells is governed by the distinct behaviour displayed by centrosomes in these cells. We have also investigated the molecular details of cilium assembly in Drosophila and have found that, as in humans, basal body fate is reserved to the mother centriole.

We maintain an active line of research to identify new centrosomal proteins and have found some with human orthologs that are linked to human pathologies.

We also work on the mechanisms that bring about genome instability in Drosophila tumours and attempt to establish the extent to which such lesions contribute to tumour progression.

Gonzalez C.
Nature, 528 (7581), 196-7 (2015)
Januschke J, Reina J, Llamazares S, Bertran T, Rossi F, Roig J and Gonzalez C.
Nat Cell Biol, 15 (3), 241-8 (2013)
Januschke J, Reina J, Llamazares S, Bertran T, Rossi F, Roig J and Gonzalez C.
Nat Cell Biol, 15 (3), 241-8 (2013)
Januschke J, Llamazares S, Reina J and Gonzalez C.
Nat Commun, 2 243 (2011)
Janic A, Mendizabal L, Llamazares S, Rossell D and Gonzalez C.
Science, 330 (6012), 1824-7 (2010)
Rebollo E, Roldán M and Gonzalez C.
Development, 13 (20), 3393-7 (2009)
Castellanos E, Dominguez P and Gonzalez C.
Curr Biol, 18 (16), 1209-14 (2008)
Caussinus E and Gonzalez C.
Nat Genet, 37 (10), 1125-9 (2005)

This group is financially supported by the following:

  • VI Framework Programme Grants, EU
  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Professors i científics treballant junts.</p>
17 Mar 2017

Els dies 17 i 18 de març, quinze professors de secundària de tot Catalunya tindran l'oportunitat d'aprendre sobre la mosca del vinagre Drosophila melanogaster, un model animal per estudiar

1 Jul 2016

Cayetano González, líder del laboratori de Divisió Cel·lular a l’IRB Barcelona, opina a la revista de divulgac

5 Oct 2015

Diversos mitjans s’han fet ressò de la publicació de Fabrizio Rossi, investigador postdoctoral a l’IRB Barcelona, i Cayetano Gonzalez, investigador ICREA i cap de

Upcoming events

19 Gen
Aula Fèlix Serratosa, Parc Científic de Barcelona
24 Gen
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Dr Travis Johnson, Lecturer, Head - Drosophila developmental biology group, Faculty of Science School of Biological Sciences, Australia
26 Gen
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Alejandra Bruna, PhD Associate Scientist Cancer Research UK Cambridge Institute University of Cambridge