Pasar al contenido principal

Laboratory of Molecular Biophysics

Trip Lab
Desactivado
Imagen
Group Leader
Telephone:
+34 93 40 20459

ICREA Research Professor, ERC Consolidator Grant

Imagen
Imagen
ICREA

Meet Our Scientists Videos

Research information

Background

Many domains in multi-domain proteins are intrinsically disordered because they do not need to fold to perform their biological functions. This observation challenges the assumption that protein functions are derived from their three-dimensional structures, which dominated thinking in molecular biology since the inception of this field.

Research interests

The laboratory mainly aims to understand the mechanisms by which intrinsically disordered proteins perform their functions. Other aims are to rationalise how specific mutations in these domains lead to disease and to identify strategies allowing drug-like small molecules to inhibit therapeutic targets rich in intrinsic disorder, which are common in oncology and neurology.

The laboratory uses a multidisciplinary approach combining biophysical techniques, theory/molecular simulations, and cell/chemical biology to study the conformations, interactions, and phase transitions of intrinsically disordered proteins of biomedical relevance, in collaboration with partners across the globe.

The research group is keen to host BSc, MSc and PhD students interested in this field, as well as postdoctoral fellows. Applicants should contact Dr. Xavier Salvatella by E-mail to discuss ongoing projects, potential openings and in general to discuss their research interests and plans for future collaboration.

Selected publications

Sanfeliu-Cerdán, N; Català-Castro, F; Mateos, B; Garcia-Cabau, C; Ribera, M; Ruider, I; Porta-de-la-Riva, M; Canals-Calderón, A; Wieser, S; Salvatella, X; Krieg, M
Nature Cell Biology
(2023)
Mensah MA, Niskanen H, Magalhaes AP, Basu S, Kircher M, Sczakiel HL, Reiter AMV, Elsner J, Meinecke P, Biskup S, Chung BHY, Dombrowsky G, Eckmann-Scholz C, Hitz MP, Hoischen A, Holterhus PM, Hülsemann W, Kahrizi K, Kalscheuer VM, Kan A, Krumbiegel M, Kurth I, Leubner J, Longardt AC, Moritz JD, Najmabadi H, Skipalova K, Snijders Blok L, Tzschach A, Wiedersberg E, Zenker M, Garcia-Cabau C, Buschow R, Salvatella X, Kraushar ML, Mundlos S, Caliebe A, Spielmann M, Horn D, Hnisz D
Nature
614
(7948 )
564 -
+
(2023)
Escobedo A, Piccirillo J, Aranda J, Diercks T, Mateos B, Garcia-Cabau C, Sánchez-Navarro M, Topal B, Biesaga M, Staby L, Kragelund BB, García J, Millet O, Orozco M, Coles M, Crehuet R, Salvatella X
Nature Communications
13
(1 )
7073 -
(2022)
Gonzalez-Arzola, K; Diaz-Quintana, A; Bernardo-Garcia, N; Martinez-Fabregas, J; Rivero-Rodriguez, F; Casado-Combreras, MA; Elena-Real, CA; Velazquez-Cruz, A; Gil-Caballero, S; Velazquez-Campoy, A; Szulc, E; Gavilan, MP; Ayala, I; Arranz, R; Rios, RM; Salvatella, X; Valpuesta, JM; Hermoso, JA; De la Rosa, MA; Diaz-Moreno, I
Nature Structural & Molecular Biology
29
(10 )
1024 -
+
(2022)
Biesaga, M; Frigolé-Vivas, M; Salvatella, X
Current Opinion In Chemical Biology
62
( )
90 -
100
(2021)
Garcia-Cabau, C; Salvatella, X
Current Opinion In Cell Biology
69
( )
111 -
119
(2021)
Eftekharzadeh, B; Banduseela, VC; Chiesa, G; Martínez-Cristóbal, P; Rauch, JN; Nath, SR; Schwarz, DMC; Shao, H; Marin-Argany, M; Di Sanza, C; Giorgetti, E; Yu, ZG; Pieratelli, R; Felli, IC; Brun-Heath, I; García, J; Nebreda, AR; Gestwicki, JE; Lieberman, AP; Salvatella, X
Nature Communications
10
(1 )
3562 -
(2019)
Escobedo, A; Topal, B; Kunze, MBA; Aranda, J; Chiesa, G; Mungianu, D; Bernardo-Seisdedos, G; Eftekharzadeh, B; Gairí, M; Pierattelli, R; Felli, IC; Diercks, T; Millet, O; García, J; Orozco, M; Crehuet, R; Lindorff-Larsen, K; Salvatella, X
Nature Communications
10
(1 )
2034 -
(2019)
Bouchard, JJ; Otero, JH; Scott, DC; Szulc, E; Martin, EW; Sabri, N; Granata, D; Marzahn, MR; Lindorff-Larsen, K; Salvatella, X; Schulman, BA; Mittag, T
Molecular Cell
72
(1 )
19 -
+
(2018)
De Mol, E; Szulc, E; Di Sanza, C; Martínez-Cristóbal, P; Bertoncini, CW; Fenwick, RB; Frigolé-Vivas, M; Masín, M; Hunter, I; Buzón, V; Brun-Heath, I; García, J; De Fabritiis, G; Estébanez-Perpiña, E; McEwan, IJ; Nebreda, AR; Salvatella, X
Structure
26
(1 )
145 -
+
(2018)
Guillén-Boixet, J; Buzon, V; Salvatella, X; Méndez, R
Elife
5
(e19298 )
e19298 -
(2016)
Eftekharzadeh, B; Piai, A; Chiesa, G; Mungianu, D; García, J; Pierattelli, R; Felli, IC; Salvatella, X
Biophysical Journal
110
(11 )
2361 -
2366
(2016)
De Mol E, Fenwick RB, Phang CT, Buzón V, Szulc E, de la Fuente A, Escobedo A, García J, Bertoncini CW, Estébanez-Perpiñá E, McEwan IJ, Riera A, Salvatella X
Acs Chemical Biology
11
(9 )
2499 -
2505
(2016)
Fenwick R; Orellana L; Esteban-Martín S; Orozco M; Salvatella X
Nature Communications
5
(4070 )
4070 -
(2014)

Projects

“ARtin. Discovery of new inhibitors of the disordered domain of the androgen receptor to treat castration-resistant prostate cancer”. El proyecto ARtin, con código INNO20010FRIG, ha recibido financiación del programa AECC Innova promovido por la Fundación Científica AECC


“Modulation of Tau seeding and pathology in tauopathies by BBB-nanocarriers, epitope selective vaccination and ectoPrP Tau receptor bodies” (STOPTauPATHOL) financiado por Fundación "la Caixa". Referencia: LCF/PR/HR19/52160007

Caixa Research

Group members

Postdoctoral Fellow
Postdoctoral Fellow
Postdoctoral Fellow
Senior Research Officer
PhD Student
Research Assistant
Research Assistant
Research Assistant
Visiting Student

What are we doing now?

Laboratory of Molecular Biophysics
28 Jul 2023

Join our research group under the framework of the INVESTIGO Programme. This is a great opportunity, check it out here!

Group News