Chemistry and Molecular PharmacologyLaboratory of Molecular Biophysics

Laboratory of Molecular Biophysics

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ and Gomis RR.
Nat Commun, 7 11199 (2016)
Fenwick RB, Orellana L, Esteban-Martín S, Orozco M and Salvatella X.
Nat Commun, 5 4070 (2014)
Candotti M, Esteban-Martín S, Salvatella X and Orozco M.
P Natl Acad Sci Usa, 110 (15), 5933-8 (2013)
Fenwick RB, Esteban-Martín S, Richter B, Lee D, Walter KF, Milovanovic D, Becker S, Lakomek NA, Griesinger C and Salvatella X.
J Am Chem Soc, 133 (27), 10336-9 (2011)
Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM and Salvatella X.
Angew Chem Int Edit, 50 (31), 7048-51 (2011)
Esteban-Martín S, Fenwick RB and Salvatella X.
J Am Chem Soc, 132 (13), 4626-32 (2010)
Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM and Salvatella X.
J Mol Biol, 402 (5), 783-96 (2010)

This group is financially supported by the following:

  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Xavier Salvatella (Photo: Battista/MinocriIRB Barcelona)</p>
12 Dic 2017

La Corporació Catalana de Mitjans Audiovisuals, La Razón y Aldia.cat han destacado, en su web, el estudio de Xavier Salvatella, investigador ICREA del IRB Barcelona, que propone atacar al cáncer de

<p>The image shows interactions between the androgen receptor protein (AR) and the TFIIF protein in red. (Author: Paula Martínez-Cristóbal)</p>
12 Dic 2017

En la mayoría de los casos, el cáncer de próstata se cura extirpando el tumor con cirugía y/o con radioterapia.

<p>CPEB4 liquid-like droplets in the cell cytoplasm (J. Guillén-Boixet, IRB Barcelona)</p>
21 Nov 2016

Las “liquid-like droplets” (gotas líquidas) son acumulaciones muy dinámicas y sin estructura aparente de proteínas en el citoplasma celular que en los últimos dos años están acaparando protagonismo

Upcoming events

24 Ene
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Dr Travis Johnson, Lecturer, Head - Drosophila developmental biology group, Faculty of Science School of Biological Sciences, Australia
26 Ene
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Alejandra Bruna, PhD Associate Scientist Cancer Research UK Cambridge Institute University of Cambridge
31 Ene
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Marta Shahbazi, Postdoctoral Fellow Department of Physiology, Development and Neuroscience, University of Cambridge, UK