Laboratory of Molecular Biophysics

Background

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Selected publications

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

Eftekharzadeh B., Banduseela V.C., Chiesa G., Martinez-Cristobal P., Rauch J.N., Nath S.R., Schwarz D.M.C., Shao H., Marin-Argany M., Di Sanza C., Giorgetti E., Yu Z., Pieratelli R., Felli I.C., Brun-Heath I., Garcia J., Nebreda A.R., Gestwicki J.E., Lieberman A.P., Salvatella X.

Nat Commun, 10 (1), (2019)

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Escobedo A, Topal B, Kunze MBA, Aranda J, Chiesa G, Mungianu D, Bernardo-Seisdedos G, Eftekharzadeh B, Gairí M, Pierattelli R, Felli IC, Diercks T, Millet O, García J, Orozco M, Crehuet R, Lindorff-Larsen K and Salvatella X.

Nat Commun, 10 (1), 2034 (2019)

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ and Gomis RR.

Nat Commun, 7 11199 (2016)

Fenwick RB, Orellana L, Esteban-Martín S, Orozco M and Salvatella X.

Nat Commun, 5 4070 (2014)

Toward an atomistic description of the urea-denatured state of proteins

Candotti M, Esteban-Martín S, Salvatella X and Orozco M.

P Natl Acad Sci Usa, 110 (15), 5933-8 (2013)

Weak long-range correlated motions in a surface patch of ubiquitin involved in molecular recognition

Fenwick RB, Esteban-Martín S, Richter B, Lee D, Walter KF, Milovanovic D, Becker S, Lakomek NA, Griesinger C and Salvatella X.

J Am Chem Soc, 133 (27), 10336-9 (2011)

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM and Salvatella X.

Angew Chem Int Edit, 50 (31), 7048-51 (2011)