Chemistry and Molecular PharmacologyLaboratory of Molecular Biophysics

Laboratory of Molecular Biophysics

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ and Gomis RR.
Nat Commun, 7 11199 (2016)
Fenwick RB, Orellana L, Esteban-Martín S, Orozco M and Salvatella X.
Nat Commun, 5 4070 (2014)
Candotti M, Esteban-Martín S, Salvatella X and Orozco M.
P Natl Acad Sci Usa, 110 (15), 5933-8 (2013)
Fenwick RB, Esteban-Martín S, Richter B, Lee D, Walter KF, Milovanovic D, Becker S, Lakomek NA, Griesinger C and Salvatella X.
J Am Chem Soc, 133 (27), 10336-9 (2011)
Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM and Salvatella X.
Angew Chem Int Edit, 50 (31), 7048-51 (2011)
Esteban-Martín S, Fenwick RB and Salvatella X.
J Am Chem Soc, 132 (13), 4626-32 (2010)
Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM and Salvatella X.
J Mol Biol, 402 (5), 783-96 (2010)

This group is financially supported by the following:

  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"


Group news & mentions

<p>CPEB4 liquid-like droplets in the cell cytoplasm (J. Guillén-Boixet, IRB Barcelona)</p>
21 Nov 2016

Liquid-like droplets are highly dynamic cytoplasmic aggregates of proteins with no apparent structure.

<p>Structure of the Androgen Receptor. NTD: N-terminal domain; DBD: DNA binding domain; LBD: Ligand binding domain. Numbers indicate the first and last aminoacids of the protein, and the domain limits.</p>
16 Aug 2016

Prostate cancer, Alzheimer’s, Parkinson’s...these three diseases are associated with proteins that share a common feature, namely disordered regions that have no apparent rigid three-dimensional st

<p>Protein Androgen Receptor forms aggregatesthat damage muscle and motor neuron cells in Kennedy's Disease (B. Eftekharzadeh, IRB Barcelona)</p>
10 Jun 2016

Knowledge of the minute details of the proteins that are linked to diseases is crucial if we are to discover therapeutic targets and thus pave the way for possible treatments.

Upcoming events

27 Sep
Aula Fèlix Serratosa, Parc Científic de Barcelona
Jordi Bella, University of Manchester, UK
27 Sep
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker: Cristina Pujades, Ph.D. Group Leader of the Department of Experimental and Health Sciences, University Pompeu Fabra, PRBB, Barcelona, Spain.
29 Sep
Serratosa Room, Parc Científic de Barcelona
Dr.Gerhard Hummer (Department of Theoretical Biophysics Max Planck Institute of Biophysics, Frankfurt and Institute of Biophysics, Goethe University Frankfurt)